Gong Q, Hu J, Wang P, Li X, Zhang X (2021) A comprehensive review on β-lapachone: mechanisms, structural modifications, and therapeutic potentials. Eur J Med Chem 210:112962. https://doi.org/10.1016/j.ejmech.2020.112962
Article CAS PubMed Google Scholar
Gomes CL, de Albuquerque Wanderley Sales V, Gomes de Melo C, Ferreira da Silva RM, Vicente Nishimura RH, Rolim LA, Rolim Neto PJ (2021) Beta-lapachone: natural occurrence, physicochemical properties, biological activities, toxicity and synthesis. Phytochemistry 186:112713. https://doi.org/10.1016/j.phytochem.2021.112713
Article CAS PubMed Google Scholar
Preethi S, Arthiga K, Patil AB, Spandana A, Jain V (2022) Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway. Mol Biol Rep 49:8907–8924. https://doi.org/10.1007/s11033-022-07369-2
Article CAS PubMed Google Scholar
Ross D, Siegel D (2021) The diverse functionality of NQO1 and its roles in redox control. Redox Biol 41:101950. https://doi.org/10.1016/j.redox.2021.101950
Article CAS PubMed PubMed Central Google Scholar
Zhang K, Chen D, Ma K, Wu X, Hao H, Jiang S (2018) NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a therapeutic and diagnostic target in Cancer. J Med Chem 61:6983–7003. https://doi.org/10.1021/acs.jmedchem.8b00124
Article CAS PubMed Google Scholar
Ehrke E, Steinmeier J, Stapelfeldt K, Dringen R (2021) The menadione-mediated WST1 reduction by cultured astrocytes depends on NQO1 activity and cytosolic glucose metabolism. Neurochem Res 46:88–99. https://doi.org/10.1007/s11064-019-02930-1
Article CAS PubMed Google Scholar
Steinmeier J, Kube S, Karger G, Ehrke E, Dringen R (2020) β-Lapachone induces acute oxidative stress in rat primary astrocyte cultures that is terminated by the NQO1-inhibitor dicoumarol. Neurochem Res 45:2442–2455. https://doi.org/10.1007/s11064-020-03104-0
Article CAS PubMed PubMed Central Google Scholar
Hart CG, Karimi-Abdolrezaee S (2021) Recent insights on astrocyte mechanisms in CNS homeostasis, pathology, and repair. J Neurosci Res 99:2427–2462. https://doi.org/10.1002/jnr.24922
Article CAS PubMed Google Scholar
Dringen R, Brandmann M, Hohnholt MC, Blumrich E-M (2015) Glutathione-dependent detoxification processes in astrocytes. Neurochem Res 40:2570–2582. https://doi.org/10.1007/s11064-014-1481-1
Article CAS PubMed Google Scholar
Bonvento G, Bolaños JP (2021) Astrocyte-neuron metabolic cooperation shapes brain activity. Cell Metabol 33:1546–1564. https://doi.org/10.1016/j.cmet.2021.07.006
Beard E, Lengacher S, Dias S, Magistretti PJ, Finsterwald C (2022) Astrocytes as key regulators of brain energy metabolism: new therapeutic perspectives. Front Physiol 12:825816. https://doi.org/10.3389/fphys.2021.825816
Article PubMed PubMed Central Google Scholar
Jiwaji Z, Hardingham GE (2022) Good, bad, and neglectful: astrocyte changes in neurodegenerative disease. Free Radic Biol Med 182:93–99. https://doi.org/10.1016/j.freeradbiomed.2022.02.020
Article CAS PubMed PubMed Central Google Scholar
Bohmbach K, Henneberger C, Hirrlinger J (2022) Astrocytes in memory formation and maintenance. Essays Biochem. https://doi.org/10.1042/ebc20220091
Park J-S, Lee Y-Y, Kim J, Seo H, Kim H-S (2016) β-Lapachone increases phase II antioxidant enzyme expression via NQO1-AMPK/PI3K-Nrf2/ARE signaling in rat primary astrocytes. Free Radic Biol Med 97:168–178. https://doi.org/10.1016/j.freeradbiomed.2016.05.024
Article CAS PubMed Google Scholar
Kim AY, Jeong K-H, Lee JH, Kang Y, Lee SH, Baik EJ (2017) Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion. Neuroscience 340:487–500. https://doi.org/10.1016/j.neuroscience.2016.11.007
Article CAS PubMed Google Scholar
Dinkova-Kostova AT, Talalay P (2010) NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector. Arch Biochem Biophys 501:116–123. https://doi.org/10.1016/j.abb.2010.03.019
Article CAS PubMed PubMed Central Google Scholar
Stapelfeldt K, Ehrke E, Steinmeier J, Rastedt W, Dringen R (2017) Menadione-mediated WST1 reduction assay for the determination of metabolic activity of cultured neural cells. Anal Biochem 538:42–52. https://doi.org/10.1016/j.ab.2017.09.011
Article CAS PubMed Google Scholar
Raabe J, Arend C, Steinmeier J, Dringen R (2019) Dicoumarol inhibits multidrug resistance protein 1-mediated export processes in cultured primary rat astrocytes. Neurochem Res 44:333–346. https://doi.org/10.1007/s11064-018-2680-y
Article CAS PubMed Google Scholar
Steinmeier J, Dringen R (2019) Exposure of cultured astrocytes to menadione triggers rapid radical formation, glutathione oxidation and Mrp1-mediated export of glutathione disulfide. Neurochem Res 44:1167–1181. https://doi.org/10.1007/s11064-019-02760-1
Article CAS PubMed Google Scholar
Dringen R, Hoepken HH, Minich T, Ruedig C (2007) Pentose phosphate pathway and NADPH metabolism. In: Lajtha A, Gibson GE, Dienel GA (eds) Handbook of neurochemistry and molecular neurobiology: brain energetics integration of molecular and cellular processes. Springer, Heidelberg, pp 41–62
Liddell JR, Zwingmann C, Schmidt MM, Thiessen A, Leibfritz D, Robinson SR, Dringen R (2009) Sustained hydrogen peroxide stress decreases lactate production by cultured astrocytes. J Neurosci Res 87:2696–2708. https://doi.org/10.1002/jnr.22093
Article CAS PubMed Google Scholar
Tulpule K, Hohnholt MC, Hirrlinger J, Dringen R (2014) Primary cultures of astrocytes and neurons as model systems to study the metabolism and metabolite export from brain cells. In: Hirrlinger J, Waagepetersen HS (eds) Brain Energy Metabolism. Springer, New York, pp 45–72
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265–275. https://doi.org/10.1016/S0021-9258(19)52451-6
Article CAS PubMed Google Scholar
Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27:502–522. https://doi.org/10.1016/0003-2697(69)90064-5
Article CAS PubMed Google Scholar
Heinz S, Freyberger A, Lawrenz B, Schladt L, Schmuck G, Ellinger-Ziegelbauer H (2017) Mechanistic investigations of the mitochondrial complex I inhibitor rotenone in the context of pharmacological and safety evaluation. Sci Rep 7:45465. https://doi.org/10.1038/srep45465
Article CAS PubMed PubMed Central Google Scholar
Slater EC (1973) The mechanism of action of the respiratory inhibitor, antimycin Biochim Biophys Acta 301:129–154. https://doi.org/10.1016/0304-4173(73)90002-5
Article CAS PubMed Google Scholar
Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL (2014) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metabolism 3:114–123. https://doi.org/10.1016/j.molmet.2013.11.005
Schmidt M, Dringen R (2009) Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes. Front Neuroenergetics 1:1–10. https://doi.org/10.3389/neuro.14.001.2009
Article CAS PubMed PubMed Central Google Scholar
Ghergurovich JM, García-Cañaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, Rabinowitz JD (2020) A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol 16:731–739. https://doi.org/10.1038/s41589-020-0533-x
Article CAS PubMed PubMed Central Google Scholar
Dehn DL, Siegel D, Swann E, Moody CJ, Ross D (2003) Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems. Mol Pharmacol 64:714–720. https://doi.org/10.1124/mol.64.3.714
Article CAS PubMed Google Scholar
Timson DJ (2017) Dicoumarol: a drug which hits at least two very different targets in vitamin K metabolism. Curr Drug Targets 18:500–510. https://doi.org/10.2174/1389450116666150722141906
Article CAS PubMed Google Scholar
Baxter PS, Hardingham GE (2016) Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes. Free Radic Biol Med 100:147–152. https://doi.org/10.1016/j.freeradbiomed.2016.06.027
Article CAS PubMed PubMed Central Google Scholar
Liu CS, Chang CK, Lin LS, Jou SB, KUo DH, Liao SS, Cheng JT (1998) Modification of superoxide dismutase (SOD) mRNA and activity by a transient hypoxic stress in cultured glial cells. Neurosci Lett 251:145–148. https://doi.org/10.1016/S0304-3940(98)00506-0
Dringen R, Hamprecht B (1997) Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells. Brain Res 759:67–75. https://doi.org/10.1016/s0006-8993(97)00233-3
留言 (0)