Pre-electroacupuncture Ameliorates Cerebral Ischemia-reperfusion Injury by Inhibiting Microglial RhoA/pyrin/GSDMD Signaling Pathway

Campbell BCV, De Silva D-A, Macleod M-R et al (2019) Ischaemic stroke[J]. Nat Rev Dis Primers 5(1):70

Article  PubMed  Google Scholar 

O’Donnell M-J, Xavier D, Liu L et al (2010) Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study[J]. Lancet 376(9735):112–123

Article  PubMed  Google Scholar 

Moretti A, Ferrari F, Villa R-F (2015) Pharmacological therapy of acute ischaemic stroke: achievements and problems[J]. Pharmacol Ther, 15379–15389

Cai L, Yao Z-Y, Yang L et al (2022) Mechanism of Electroacupuncture Against Cerebral Ischemia-Reperfusion Injury: reducing inflammatory response and cell pyroptosis by inhibiting NLRP3 and Caspase-1[J]. Front Mol Neurosci, 15822088

Yao D, Zhang R, Xie M et al (2023) Updated understanding of the glial-vascular unit in Central Nervous System Disorders[J]. Neurosci Bull 39(3):503–518

Article  PubMed  Google Scholar 

X Hu, Li P, Guo Y et al (2012) Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia[J]. Stroke 43(11):3063–3070

Article  Google Scholar 

Zhou C, Li J-X, Zheng C-X et al (2024) Neuroprotective effects of Jie-Du-Huo-Xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion–from the perspective of glial-vascular unit[J]. J Ethnopharmacol 318(Pt B):116990

Article  CAS  PubMed  Google Scholar 

Broz P, Pelegrin P, Shao F (2020) The gasdermins, a protein family executing cell death and inflammation[J]. Nat Rev Immunol 20(3):143–157

Article  CAS  PubMed  Google Scholar 

Li J, Xu P, Hong Y et al (2023) Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury[J]. J Neuroinflammation 20(1):148

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai W, Wu Z, Lai J et al (2023) LDC7559 inhibits microglial activation and GSDMD-dependent pyroptosis after subarachnoid hemorrhage[J]. Front Immunol, 141117310

Hodge R-G, Ridley A-J (2016) Regulating rho GTPases and their regulators[J]. Nat Rev Mol Cell Biol 17(8):496–510

Article  CAS  PubMed  Google Scholar 

Lu W, Chen Z, Wen J (2023) The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation[J]. Biomed Pharmacother, 165115141

Glotfelty E-J, Tovar-Y-Romo L-B, Hsueh S-C et al (2023) The RhoA-ROCK1/ROCK2 pathway exacerbates Inflammatory Signaling in Immortalized and primary Microglia[J]. Cells, 12(10)

Wang J, Ni G, Liu Y et al (2020) Tanshinone IIA promotes axonal regeneration in rats with focal cerebral ischemia through the inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling[J]. Drug Des Devel Ther, pp 142775–142787

Xu H, Yang J, Gao W et al (2014) Innate immune sensing of bacterial modifications of rho GTPases by the pyrin inflammasome[J]. Nature 513(7517):237–241

Article  CAS  PubMed  Google Scholar 

Park Y-H, Wood G, Kastner D-L et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS[J]. Nat Immunol 17(8):914–921

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schnappauf O, Chae J-J, Kastner D-L et al (2019) The pyrin inflammasome in Health and Disease[J]. Front Immunol, 101745

Ding H, Cheng Q, Fang X et al (2023) Dihydromyricetin Alleviates Ischemic Brain Injury by Antagonizing Pyroptosis in Rats[J]. Neurotherapeutics

Ran Y, Su W, Gao F et al (2021) Curcumin ameliorates White Matter Injury after ischemic stroke by inhibiting Microglia/Macrophage pyroptosis through NF-kappaB suppression and NLRP3 inflammasome Inhibition[J]. Oxid Med Cell Longev, 20211552127

Zhou J, Fu Y-B, Song Y-Q et al (2024) Progress of researches on mechanisms of acupuncture for secondary prevention of ischemic stroke[J]. Zhen Ci Yan Jiu 49(6):625–633

PubMed  Google Scholar 

Zhang H, Jin B, You X et al (2023) Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke[J]. Chin Herb Med 15(4):496–508

PubMed  PubMed Central  Google Scholar 

Mao J-J, Liou K-T, Baser R-E et al (2021) Effectiveness of electroacupuncture or auricular acupuncture vs Usual Care for Chronic Musculoskeletal Pain among Cancer survivors: the PEACE Randomized Clinical Trial[J]. JAMA Oncol 7(5):720–727

Article  PubMed  Google Scholar 

Shen J, Wenger N, Glaspy J et al (2000) Electroacupuncture for control of myeloablative chemotherapy-induced emesis: a randomized controlled trial[J]. JAMA 284(21):2755–2761

Article  CAS  PubMed  Google Scholar 

Yin X, Li W, Liang T et al (2022) Effect of electroacupuncture on Insomnia in patients with Depression: a randomized clinical Trial[J]. JAMA Netw Open 5(7):e2220563

Article  PubMed  PubMed Central  Google Scholar 

Liu Z, Liu Y, Xu H et al (2017) Effect of electroacupuncture on urinary leakage among women with stress urinary incontinence: a randomized clinical Trial[J]. JAMA 317(24):2493–2501

Article  PubMed  PubMed Central  Google Scholar 

Zhang Z-J, Man S-C, Yam L-L et al (2020) Electroacupuncture trigeminal nerve stimulation plus body acupuncture for chemotherapy-induced cognitive impairment in breast cancer patients: an assessor-participant blinded, randomized controlled trial[J]. Brain Behav Immun, 8888–8896

Ma Z, Zhang Z, Bai F et al (2019) Electroacupuncture pretreatment alleviates cerebral ischemic Injury through alpha7 nicotinic acetylcholine receptor-mediated phenotypic Conversion of Microglia[J]. Front Cell Neurosci, 13537

Mei Z-G, Huang Y-G, Feng Z-T et al (2020) Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway[J]. Aging 12(13):13187–13205

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang C, Liu J, Wang J et al (2021) Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture[J]. J Cereb Blood Flow Metab 41(9):2295–2310

Article  CAS  PubMed  PubMed Central  Google Scholar 

Young-Wook P, Min Jae-K GY-H et al (2019) Subacute electroacupuncture at Baihui (GV 20) and Dazhui (GV 14) promotes post-stroke functional recovery via neurogenesis and astrogliosis in a photothrombotic stroke mouse model[J]. J Tradit Chin Med 39(6):833–841

PubMed  Google Scholar 

Zheng S-M, Zhao F-L, Luo Y-Y et al (2020) [Clinical effect of electroacupuncture at Baihui and Shuigou points in treatment of brain injury in patients with sepsis-associated encephalopathy][J]. Zhen Ci Yan Jiu 45(5):402–406

PubMed  Google Scholar 

Xia K-P, Pang J, Li S-L et al (2020) [Effect of electroacupuncture at governor vessel on learning-memory ability and serum level of APP, Abeta(1–42) in patients with Alzheimer’s disease][J]. Zhongguo Zhen Jiu 40(4):375–378

PubMed  Google Scholar 

Wang H-L, Liu F-L, Li R-Q et al (2021) Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation[J]. Neural Regen Res 16(6):1011–1016

Article  CAS  PubMed  Google Scholar 

Pang F, Yang Y, Huang S et al (2023) Electroacupuncture alleviates depressive-like behavior by modulating the expression of P2X7/NLRP3/IL-1beta of Prefrontal Cortex and liver in rats exposed to chronic unpredictable mild Stress[J]. Brain Sci, 13(3)

Liu Q, Li B, Zhu H-Y et al (2011) Glia atrophy in the hippocampus of chronic unpredictable stress-induced depression model rats is reversed by electroacupuncture treatment[J]. J Affect Disord 128(3):309–313

Article  CAS  PubMed  Google Scholar 

Chavez L-M, Huang S-S, MacDonald I et al (2017) Mechanisms of acupuncture therapy in Ischemic Stroke Rehabilitation: A literature review of Basic Studies[J]. Int J Mol Sci, 18(11)

Zhang H-Y, Zhao Y-J, Zhang P-J et al (2022) [Acupuncture ameliorates neurological function by suppressing microglia polarization and inflammatory response after cerebral ischemia in rats][J]. Zhen Ci Yan Jiu 47(11):941–948

CAS  PubMed  Google Scholar 

Kim Y-R, Kim H-N, Ahn S-M et al (2014) Electroacupuncture promotes post-stroke functional recovery via enhancing endogenous neurogenesis in mouse focal cerebral ischemia[J]. PLoS ONE 9(2):e90000

Article  PubMed  PubMed Central  Google Scholar 

Jung Y-S, Lee S-W, Park J-H et al (2016) Electroacupuncture preconditioning reduces ROS generation with NOX4 down-regulation and ameliorates blood-brain barrier disruption after ischemic stroke[J]. J Biomed Sci, 2332

Longa E-Z, Weinstein P-R, Carlson S et al (1989) Reversible middle cerebral artery occlusion without craniectomy in rats[J]. Stroke 20(1):84–91

Article  CAS  PubMed  Google Scholar 

Eldahshan W, Fagan S-C, Ergul A (2019) Inflammation within the neurovascular unit: focus on microglia for stroke injury and recovery[J]. Pharmacol Res, 147104349

Tuo Q-Z, Zhang S-T, Lei P (2022) Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications[J]. Med Res Rev 42(1):259–305

Article  PubMed  Google Scholar 

Jing F, Zhang Y, Long T et al (2019) P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine[J]. J Neuroinflammation 16(1):217

Article  PubMed  PubMed Central  Google Scholar 

Zhu Z, Lu J, Wang S et al (2022) Acrolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: involvement of RhoA/ROCK2 pathway[J]. Aging Cell 21(4):e13587

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Wang Q, Sun X et al (2023) Activation of RhoA pathway participated in the changes of emotion, cognitive function and hippocampal synaptic plasticity in juvenile chronic stress rats[J]. Int J Biol Macromol, 233123652

Dirnagl U, Becker K, Meisel A (2009) Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use[J]. Lancet Neurol 8(4):398–412

Article  CAS  PubMed 

留言 (0)

沒有登入
gif