WHO/The Global Health Observatory. Global health estimates: leading causes of death 2000–2019. https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-leading-causes-of-death (2023).

Lozano, R. et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease study 2010. Lancet 380, 2095–2128 (2012).

Article  PubMed  Google Scholar 

Lim, S. S. et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2224–2260 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Murray, C. J. et al. GBD 2010: design, definitions, and metrics. Lancet 380, 2063–2066 (2012).

Article  PubMed  Google Scholar 

Sing, C. F., Stengard, J. H. & Kardia, S. L. Genes, environment, and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 23, 1190–1196 (2003).

Article  CAS  PubMed  Google Scholar 

GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396, 1223–1249 (2020).

Article  Google Scholar 

WHO/The Global Health Observatory. Noncommunicable diseases: mortality. https://www.who.int/data/gho/data/themes/topics/topic-details/GHO/ncd-mortality (2023).

Buniello, A. et al. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res. 47, D1005–D1012 (2019).

Article  CAS  PubMed  Google Scholar 

Rappaport, S. M. Genetic factors are not the major causes of chronic diseases. PLoS One 11, e0154387 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Munzel, T. et al. Heart healthy cities: genetics loads the gun but the environment pulls the trigger. Eur. Heart J. 42, 2422–2438 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Olden, K. & Wilson, S. Environmental health and genomics: visions and implications. Nat. Rev. Genet. 1, 149–153 (2000).

Article  CAS  PubMed  Google Scholar 

Landrigan, P. J. et al. The Lancet Commission on pollution and health. Lancet 391, 462–512 (2018).

Article  PubMed  Google Scholar 

Ramirez-Rubio, O. et al. Urban health: an example of a “health in all policies” approach in the context of SDGs implementation. Glob. Health 15, 87 (2019).

Article  Google Scholar 

Patel, C. J., Bhattacharya, J. & Butte, A. J. An environment-wide association study (EWAS) on type 2 diabetes mellitus. PLoS One 5, e10746 (2010).

Article  PubMed  PubMed Central  Google Scholar 

Zheng, Y. et al. Design and methodology challenges of environment-wide association studies: a systematic review. Environ. Res. 183, 109275 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sainani, K. Taking on the exposome — bringing bioinformatics tools to the environmental side of the health equation. https://humanexposomeproject.com/wp-content/uploads/2017/01/Taking-on-the-Exposome.pdf (2016).

Lelieveld, J. et al. Loss of life expectancy from air pollution compared to other risk factors: a worldwide perspective. Cardiovasc. Res. 116, 1910–1917 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

WHO. An estimated 12.6 million deaths each year are attributable to unhealthy environments. https://www.who.int/news/item/15-03-2016-an-estimated-12-6-million-deaths-each-year-are-attributable-to-unhealthy-environments (2016).

WHO. Preventing disease through healthy environments: a global assessment of the burden of disease from environmental risks. https://www.who.int/publications/i/item/9789241565196 (2018).

Lelieveld, J. et al. Cardiovascular disease burden from ambient air pollution in Europe reassessed using novel hazard ratio functions. Eur. Heart J. 40, 1590–1596 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Kindi, S. G., Brook, R. D., Biswal, S. & Rajagopalan, S. Environmental determinants of cardiovascular disease: lessons learned from air pollution. Nat. Rev. Cardiol. 17, 656–672 (2020).

Article  PubMed  PubMed Central  Google Scholar 

European Environment Agency. Health impacts of air pollution in Europe, 2021. https://www.eea.europa.eu/publications/air-quality-in-europe-2021/health-impacts-of-air-pollution (2021).

Stafoggia, M. et al. Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project. Lancet Planet. Health 6, e9–e18 (2022).

Article  PubMed  Google Scholar 

Rich, D. Q. et al. Association between changes in air pollution levels during the Beijing Olympics and biomarkers of inflammation and thrombosis in healthy young adults. JAMA 307, 2068–2078 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yorifuji, T., Kashima, S. & Doi, H. Fine-particulate air pollution from diesel emission control and mortality rates in Tokyo: a quasi-experimental study. Epidemiology 27, 769–778 (2016).

Article  PubMed  Google Scholar 

Correia, A. W. et al. Effect of air pollution control on life expectancy in the United States: an analysis of 545 U.S. counties for the period from 2000 to 2007. Epidemiology 24, 23–31 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Pope, C. A. III, Ezzati, M. & Dockery, D. W. Fine-particulate air pollution and life expectancy in the United States. N. Engl. J. Med. 360, 376–386 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

GBD 2015 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388, 1603–1658 (2016).

Article  Google Scholar 

Boogaard, H. et al. Long-term exposure to traffic-related air pollution and selected health outcomes: A systematic review and meta-analysis. Environ. Int. 164, 107262 (2022).

Article  CAS  PubMed  Google Scholar 

Nieuwenhuijsen, M. J., Khreis, H., Triguero-Mas, M., Gascon, M. & Dadvand, P. Fifty shades of green: pathway to healthy urban living. Epidemiology 28, 63–71 (2017).

Article  PubMed  Google Scholar 

Fuller, R. et al. Pollution and health: a progress update. Lancet Planet. Health 6, e535–e547 (2022).

Article  PubMed  Google Scholar 

Munzel, T., Hahad, O., Daiber, A. & Landrigan, P. J. Soil and water pollution and human health: what should cardiologists worry about? Cardiovasc. Res. 119, 440–449 (2023).

Article  PubMed  Google Scholar 

Kumar, A. et al. Lead toxicity: health hazards, influence on food chain, and sustainable remediation approaches. Int. J. Environ. Res. Public Health 17, 2179 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alissa, E. M. & Ferns, G. A. Heavy metal poisoning and cardiovascular disease. J. Toxicol. 2011, 870125 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Cosselman, K. E., Navas-Acien, A. & Kaufman, J. D. Environmental factors in cardiovascular disease. Nat. Rev. Cardiol. 12, 627–642 (2015).

Article  CAS  PubMed  Google Scholar 

Kempen, E. V., Casas, M., Pershagen, G. & Foraster, M. WHO environmental noise guidelines for the European region: a systematic review on environmental noise and cardiovascular and metabolic effects: a summary. Int. J. Environ. Res. Public Health 15, 379 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Roswall, N. et al. Long-term exposure to transportation noise and risk of incident stroke: a pooled study of nine scandinavian cohorts. Environ. Health Perspect. 129, 107002 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Munzel, T., Sørensen, M. & Daiber, A. Transportation noise pollution and cardiovascular disease. Nat. Rev. Cardiol. 18, 619–636 (2021).

Article  PubMed  Google Scholar 

European Environment Agency. Environmental noise in Europe — 2020. https://www.eea.europa.eu/publications/environmental-noise-in-europe (2020).

Khomenko, S. et al. Impact of road traffic noise on annoyance and preventable mortality in European cities: a health impact assessment. Environ. Int. 162, 107160 (2022).

Article  PubMed  Google Scholar 

Thacher, J. D. et al. Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark. Environ. Res. 211, 113106 (2022).

Article  CAS  PubMed  Google Scholar 

Vienneau, D. et al. Transportation noise exposure and cardiovascular mortality: 15-years of follow-up in a nationwide prospective cohort in Switzerland. Environ. Int. 158, 106974 (2022).

Article  PubMed  Google Scholar 

Falchi, F. et al. The new world atlas of artificial night sky brightness. Sci. Adv. 2, e1600377 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Falchi, F. et al. Light pollution in USA and Europe: the good, the bad and the ugly. J. Environ. Manag. 248, 109227 (2019).

Article