Libby, P. The changing landscape of atherosclerosis. Nature 592, 524–533 (2021).

Article  CAS  PubMed  Google Scholar 

Sima, P., Vannucci, L. & Vetvicka, V. Atherosclerosis as autoimmune disease. Ann. Transl. Med. 6, 116 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Xie, C. B. et al. Complement membrane attack complexes assemble NLRP3 inflammasomes triggering IL-1 activation of IFN-γ-primed human endothelium. Circ. Res. 124, 1747–1759 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

West, E. E. & Kemper, C. Complosome – the intracellular complement system. Nat. Rev. Nephrol. 19, 426–439 (2023).

Article  PubMed  Google Scholar 

Kolev, M. et al. Complement regulates nutrient influx and metabolic reprogramming during Th1 cell responses. Immunity 42, 1033–1047 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arbore, G. et al. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science 352, aad1210 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Kimura, Y. et al. Expression of complement 3 and complement 5 in newt limb and lens regeneration. J. Immunol. 170, 2331–2339 (2003).

Article  CAS  PubMed  Google Scholar 

Carter, A. M. Complement activation: an emerging player in the pathogenesis of cardiovascular disease. Scientifica 2012, 402783 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Libby, P. et al. Atherosclerosis. Nat. Rev. Dis. Prim. 5, 56 (2019).

Article  PubMed  Google Scholar 

Gimbrone, M. A. & García-Cardeña, G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ. Res. 118, 620–636 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bäck, M., Yurdagul, A., Tabas, I., Öörni, K. & Kovanen, P. T. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nat. Rev. Cardiol. 16, 389–406 (2019).

PubMed  PubMed Central  Google Scholar 

Miller, Y. I. et al. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ. Res. 108, 235–248 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Binder, C. J., Papac-Milicevic, N. & Witztum, J. L. Innate sensing of oxidation-specific epitopes in health and disease. Nat. Rev. Immunol. 16, 485–497 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Javadifar, A. et al. Foam cells as therapeutic targets in atherosclerosis with a focus on the regulatory roles of non-coding RNAs. Int. J. Mol. Sci. 22, 2529 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moore, K. J. & Tabas, I. Macrophages in the pathogenesis of atherosclerosis. Cell 145, 341–355 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duewell, P. et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357–1361 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yildirim, Z. et al. Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression. EMBO Mol. Med. 14, e15344 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, T. et al. Endoplasmic reticulum stress affects cholesterol homeostasis by inhibiting LXRα expression in hepatocytes and macrophages. Nutrients 12, 3088 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Viaud, M. et al. Lysosomal cholesterol hydrolysis couples efferocytosis to anti-inflammatory oxysterol production. Circ. Res. 122, 1369–1384 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yvan-Charvet, L. et al. ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ. Res. 106, 1861–1869 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar, D., Pandit, R. & Yurdagul, A. Mechanisms of continual efferocytosis by macrophages and its role in mitigating atherosclerosis. Immunometabolism 5, e00017 (2023).

Article  PubMed  Google Scholar 

Wezel, A. et al. Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression. Atherosclerosis 241, 289–296 (2015).

Article  CAS  PubMed  Google Scholar 

Fernandez, D. M. et al. Single-cell immune landscape of human atherosclerotic plaques. Nat. Med. 25, 1576–1588 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Winkels, H. & Wolf, D. Heterogeneity of T cells in atherosclerosis defined by single-cell RNA-sequencing and cytometry by time of flight. Arterioscler. Thromb. Vasc. Biol. 41, 549–563 (2021).

Article  CAS  PubMed  Google Scholar 

Engelen, S. E., Robinson, A. J. B., Zurke, Y.-X. & Monaco, C. Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed? Nat. Rev. Cardiol. 19, 522–542 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saigusa, R., Winkels, H. & Ley, K. T cell subsets and functions in atherosclerosis. Nat. Rev. Cardiol. 17, 387–401 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ketelhuth, D. F. J. & Hansson, G. K. Adaptive response of T and B cells in atherosclerosis. Circ. Res. 118, 668–678 (2016).

Article  CAS  PubMed  Google Scholar 

Mangge, H., Prüller, F., Schnedl, W., Renner, W. & Almer, G. Beyond macrophages and T cells: B cells and immunoglobulins determine the fate of the atherosclerotic plaque. Int. J. Mol. Sci. 21, 4082 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sage, A. P., Tsiantoulas, D., Binder, C. J. & Mallat, Z. The role of B cells in atherosclerosis. Nat. Rev. Cardiol. 16, 180–196 (2019).

Article  CAS  PubMed  Google Scholar 

Hu, D. et al. Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity 42, 1100–1115 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siedlinski, M. et al. White blood cells and blood pressure: a Mendelian randomization study. Circulation 141, 1307–1317 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mohanta, S. K. et al. Neuroimmune cardiovascular interfaces control atherosclerosis. Nature 605, 152–159 (2022).

Article  CAS  PubMed  Google Scholar 

West, E. E., Woodruff, T., Fremeaux-Bacchi, V. & Kemper, C. Complement in human disease: approved and up-and-coming therapeutics. Lancet 403, 392–405 (2024).

Article  CAS  PubMed  Google Scholar 

Dutta, K., Friscic, J. & Hoffmann, M. H. Targeting the tissue-complosome for curbing inflammatory disease. Semin. Immunol. 60, 101644 (2022).

Article  CAS  PubMed  Google Scholar 

Flajnik, M, Singh, N. J. & Holland, S. M. Paul’s Fundamental Immunology 8th edn (LWW, 2022).

Merle, N. S., Church, S. E., Fremeaux-Bacchi, V. & Roumenina, L. T. Complement system part I – molecular mechanisms of activation and regulation. Front. Immunol. 6, 262 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Murphy, K., Weaver, C. & Berg, L. Janeway’s Immunobiology 10th edn (Norton, 2022).

Merle, N. S., Noe, R., Halbwachs-Mecarelli, L., Fremeaux-Bacchi, V. & Roumenina, L. T. Complement system part II: role in immunity. Front. Immunol. 6, 257 (2015).

Article  PubMed  PubMed Central