Brisken C, Rajaram RD. Alveolar and lactogenic differentiation. J Mammary Gland Biol Neoplasia. 2006;11(3–4):239–48.

Article  PubMed  Google Scholar 

Richert MM, Schwertfeger KL, Ryder JW, Anderson SM. An atlas of mouse mammary gland development. J Mammary Gland Biol Neoplasia. 2000;5(2):227–41.

Article  CAS  PubMed  Google Scholar 

Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, Rock J, et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011;479(7372):189–93.

Article  PubMed  Google Scholar 

Elias S, Morgan MA, Bikoff EK, Robertson EJ. Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life. Nat Commun. 2017;8(1):1714.

Article  PubMed  PubMed Central  Google Scholar 

Bach K, Pensa S, Grzelak M, Hadfield J, Adams DJ, Marioni JC, et al. Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing. Nat Commun. 2017;8(1):2128.

Article  PubMed  PubMed Central  Google Scholar 

Truchet S, Honvo-Houeto E. Physiology of milk secretion. Best Pract Res Clin Endocrinol Metab. 2017;31(4):367–84.

Article  CAS  PubMed  Google Scholar 

Burgoyne RD, Duncan JS. Secretion of milk proteins. J Mammary Gland Biol Neoplasia. 1998;3(3):275–86.

Article  CAS  PubMed  Google Scholar 

Anderson SM, Rudolph MC, Mcmanaman JL, Neville MC. Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis! Breast Cancer Res. 2007;9(1):204.

Article  PubMed  PubMed Central  Google Scholar 

Shennan DB. Mammary gland membrane transport systems. J Mammary Gland Biol Neoplasia. 1998;3(3):247–58.

Article  CAS  PubMed  Google Scholar 

Zhao FQ. Biology of glucose transport in the mammary gland. J Mammary Gland Biol Neoplasia. 2014;19(1):3–17.

Article  PubMed  Google Scholar 

Patel OV, Casey T, Plaut K. Profiling solute-carrier transporters in key metabolic tissues during the postpartum evolution of mammary epithelial cells from nonsecretory to secretory. Physiol Genomics. 2019;51(11):539–52.

Article  CAS  PubMed  Google Scholar 

Mobasheri A, Kendall BH, Maxwell JE, Sawran AV, German AJ, Marples D, et al. Cellular localization of aquaporins along the secretory pathway of the lactating bovine mammary gland: an immunohistochemical study. Acta Histochem. 2011;113(2):137–49.

Article  CAS  PubMed  Google Scholar 

Clermont Y, Xia L, Rambourg A, Turner JD, Hermo L. Transport of casein submicelles and formation of secretion granules in the Golgi apparatus of epithelial cells of the lactating mammary gland of the rat. Anat Rec. 1993;235(3):363–73.

Article  CAS  PubMed  Google Scholar 

Ramakrishnan B, Boeggeman E, Qasba PK. Beta-1,4-galactosyltransferase and lactose synthase: molecular mechanical devices. Biochem Biophys Res Commun. 2002;291(5):1113–8.

Article  CAS  PubMed  Google Scholar 

Truchet S, Chat S, Ollivier-Bousquet M. Milk secretion: the role of SNARE proteins. J Mammary Gland Biol Neoplasia. 2014;19(1):119–30.

Article  PubMed  Google Scholar 

Mcmanaman JL, Neville MC. Mammary physiology and milk secretion. Adv Drug Deliv Rev. 2003;55(5):629–41.

Article  CAS  PubMed  Google Scholar 

Argov-Argaman N. Symposium review: Milk fat globule size: practical implications and metabolic regulation. J Dairy Sci. 2019;102(3):2783–95.

Article  CAS  PubMed  Google Scholar 

Chong BM, Reigan P, Mayle-Combs KD, Orlicky DJ, Mcmanaman JL. Determinants of adipophilin function in milk lipid formation and secretion. Trends Endocrinol Metab. 2011;22(6):211–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Groner B, Gouilleux F. Prolactin-mediated gene activation in mammary epithelial cells. Curr Opin Genet Dev. 1995;5(5):587–94.

Article  CAS  PubMed  Google Scholar 

Rudolph MC, Russell TD, Webb P, Neville MC, Anderson SM. Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell. Am J Physiol Endocrinol Metab. 2011;300(6):E1059–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen CC, Boxer RB, Stairs DB, Portocarrero CP, Horton RH, Alvarez JV, et al. Akt is required for Stat5 activation and mammary differentiation. Breast Cancer Res. 2010;12(5):R72.

Article  PubMed  PubMed Central  Google Scholar 

Doppler W, Geymayer S, Weirich HG. Synergistic and antagonistic interactions of transcription factors in the regulation of milk protein gene expression. Mechanisms of cross-talk between signalling pathways. Adv Exp Med Biol. 2000;480:139–46.

Article  CAS  PubMed  Google Scholar 

Groner B, Altiok S, Meier V. Hormonal regulation of transcription factor activity in mammary epithelial cells. Mol Cell Endocrinol. 1994;100(1–2):109–14.

Article  CAS  PubMed  Google Scholar 

Faulds MH, Olsen H, Helguero LA, Gustafsson JA, Haldosen LA. Estrogen receptor functional activity changes during differentiation of mammary epithelial cells. Mol Endocrinol. 2004;18(2):412–21.

Article  CAS  PubMed  Google Scholar 

Buser AC, Gass-Handel EK, Wyszomierski SL, Doppler W, Leonhardt SA, Schaack J, et al. Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells. Mol Endocrinol. 2007;21(1):106–25.

Article  CAS  PubMed  Google Scholar 

Chiba T, Kimura S, Takahashi K, Morimoto Y, Sanbe A, Ueda H, et al. Serotonin suppresses beta-casein expression via inhibition of the signal transducer and activator of transcription 5 (STAT5) protein phosphorylation in human mammary epithelial cells MCF-12A. Biol Pharm Bull. 2014;37(8):1336–40.

Article  CAS  PubMed  Google Scholar 

Boutinaud M, Jammes H. Growth hormone increases Stat5 and Stat1 expression in lactating goat mammary gland: a specific effect compared to milking frequency. Domest Anim Endocrinol. 2004;27(4):363–78.

Article  CAS  PubMed  Google Scholar 

Shea-Eaton WK, Lee PP, Ip MM. Regulation of milk protein gene expression in normal mammary epithelial cells by tumor necrosis factor. Endocrinology. 2001;142(6):2558–68.

Article  CAS  PubMed  Google Scholar 

Molento CF, Block E, Cue RI, Petitclerc D. Effects of insulin, recombinant bovine somatotropin, and their interaction on insulin-like growth factor-I secretion and milk protein production in dairy cows. J Dairy Sci. 2002;85(4):738–47.

Article  CAS  PubMed  Google Scholar 

Kobayashi K, Omatsu N, Han L, Shan-Ni L, Nishimura T. Early effects of lipoteichoic acid from Staphylococcus aureus on milk production-related signaling pathways in mouse mammary epithelial cells. Exp Cell Res. 2022;420(1):113352.

Article  CAS  PubMed  Google Scholar 

Yu M, Qi H, Gao X. Daidzein promotes milk synthesis and proliferation of mammary epithelial cells via the estrogen receptor alpha-dependent NFkappaB1 activation. Anim Biotechnol. 2022;33(1):43–52.

Article  CAS  PubMed  Google Scholar 

Tsugami Y, Wakasa H, Kawahara M, Nishimura T, Kobayashi K. Isoflavones and their metabolites influence the milk production ability of bovine mammary epithelial cells in a type-specific manner. Anim Sci J. 2022;93(1):e13720.

Article  CAS  PubMed  Google Scholar 

Geng Z, Shan X, Lian S, Wang J, Wu R. LPS-induced SOCS3 antagonizes the JAK2-STAT5 pathway and inhibits beta-casein synthesis in bovine mammary epithelial cells. Life Sci. 2021;278:119547.

Article  CAS  PubMed  Google Scholar 

Suzuki N, Tsugami Y, Wakasa H, Suzuki T, Nishimura T, Kobayashi K. Menthol From Mentha piperita suppresses the Milk production of lactating mammary epithelial cells in vivo and in vitro. Mol Nutr Food Res. 2020;64:e2000853.

Article  Google Scholar 

Kobayashi K, Tsugami Y, Suzuki N, Suzuki T, Nishimura T. Nicotine directly affects milk production in lactating mammary epithelial cells concurrently with inactivation of STAT5 and glucocorticoid receptor in vitro. Toxicol in Vitro. 2020;63:104741.

Article  CAS  PubMed  Google Scholar 

Tobon H, Salazar H. Ultrastructure of the human mammary gland. II. Postpartum lactogenesis. J Clin Endocrinol Metab. 1975;40(5):834–44.

Article  CAS  PubMed  Google Scholar 

Nguyen DA, Neville MC. Tight junction regulation in the mammary gland. J Mammary Gland Biol Neoplasia. 1998;3(3):233–46.