Simon, D. B. et al. Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science 285, 103–106 (1999).
Article CAS PubMed Google Scholar
Kausalya, P. J. et al. Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of claudin-16. J. Clin. Invest. 116, 878–891 (2006).
Article CAS PubMed PubMed Central Google Scholar
Wilcox, E. R. et al. Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29. Cell 104, 165–172 (2001).
Article CAS PubMed Google Scholar
Ben-Yosef, T. et al. Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Hum. Mol. Genet. 12, 2049–2061 (2003).
Article CAS PubMed Google Scholar
Zhao, J. et al. Multiple claudin–claudin cis interfaces are required for tight junction strand formation and inherent flexibility. Commun. Biol. 1, 50 (2018).
Article PubMed PubMed Central Google Scholar
Wattenhofer, M. et al. Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro. Hum. Mutat. 25, 543–549 (2005).
Article CAS PubMed Google Scholar
Hooper, L. V., Littman, D. R. & Macpherson, A. J. Interactions between the microbiota and the immune system. Science 336, 1268–1273 (2012).
Article CAS PubMed PubMed Central Google Scholar
Buckley, A. & Turner, J. R. Cell biology of tight junction barrier regulation and mucosal disease. Cold Spring Harb. Perspect. Biol. 10, a029314 (2018).
Article PubMed PubMed Central Google Scholar
Wada, M., Tamura, A., Takahashi, N. & Tsukita, S. Loss of claudins 2 and 15 from mice causes defects in paracellular Na+ flow and nutrient transport in gut and leads to death from malnutrition. Gastroenterology 144, 369–380 (2013).
Article CAS PubMed Google Scholar
Odenwald, M. A. & Turner, J. R. Intestinal permeability defects: is it time to treat? Clin. Gastroenterol. Hepatol. 11, 1075–1083 (2013).
Article PubMed PubMed Central Google Scholar
Odenwald, M. A. & Turner, J. R. The intestinal epithelial barrier: a therapeutic target? Nat. Rev. Gastroenterol. Hepatol. 14, 9–21 (2017).
Article CAS PubMed Google Scholar
Camilleri, M. Leaky gut: mechanisms, measurement and clinical implications in humans. Gut 68, 1516–1526 (2019).
Article CAS PubMed Google Scholar
Brien, T. G., O’Hagan, R. & Muldowney, F. P. Chromium-51-EDTA in the determination of glomerular filtration rate. Acta Radiol. Ther. Phys. Biol. 8, 523–529 (1969).
Article CAS PubMed Google Scholar
Ukabam, S. O., Clamp, J. R. & Cooper, B. T. Abnormal small intestinal permeability to sugars in patients with Crohn’s disease of the terminal ileum and colon. Digestion 27, 70–74 (1983).
Article CAS PubMed Google Scholar
Howden, C. W., Robertson, C., Duncan, A., Morris, A. J. & Russell, R. I. Comparison of different measurements of intestinal permeability in inflammatory bowel disease. Am. J. Gastroenterol. 86, 1445–1449 (1991).
Peeters, M. et al. Increased permeability of macroscopically normal small bowel in Crohn’s disease. Dig. Dis. Sci. 39, 2170–2176 (1994).
Article CAS PubMed Google Scholar
Johansson, J. E. & Ekman, T. Gut toxicity during hemopoietic stem cell transplantation may predict acute graft-versus-host disease severity in patients. Dig. Dis. Sci. 52, 2340–2345 (2007).
Wyatt, J., Vogelsang, H., Hubl, W., Waldhoer, T. & Lochs, H. Intestinal permeability and the prediction of relapse in Crohn’s disease. Lancet 341, 1437–1439 (1993).
Article CAS PubMed Google Scholar
D’Inca, R. et al. Intestinal permeability test as a predictor of clinical course in Crohn’s disease. Am. J. Gastroenterol. 94, 2956–2960 (1999).
Bitton, A. et al. Predicting relapse in Crohn’s disease: a biopsychosocial model. Gut 57, 1386–1392 (2008).
Article CAS PubMed Google Scholar
Meddings, J. B. & Swain, M. G. Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat. Gastroenterology 119, 1019–1028 (2000).
Article CAS PubMed Google Scholar
Buhner, S. et al. Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation? Gut 55, 342–347 (2006).
Article CAS PubMed PubMed Central Google Scholar
Torres, J. et al. Serum biomarkers identify patients who will develop inflammatory bowel diseases up to 5 years before diagnosis. Gastroenterology 159, 96–104 (2020).
Article CAS PubMed Google Scholar
Turpin, W. et al. Increased intestinal permeability is associated with later development of Crohn’s disease. Gastroenterology 159, 2092–2100.e5 (2020).
Article CAS PubMed Google Scholar
Lee, S. H. et al. Anti-microbial antibody response is associated with future onset of Crohn’s disease independent of biomarkers of altered gut barrier function, subclinical inflammation, and genetic risk. Gastroenterology 161, 1540–1551 (2021).
Article CAS PubMed Google Scholar
Edwinson, A. L. et al. Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome. Nat. Microbiol. 7, 680–694 (2022).
Article CAS PubMed PubMed Central Google Scholar
Camilleri, M. & Gorman, H. Intestinal permeability and irritable bowel syndrome. Neurogastroenterol. Motil. 19, 545–552 (2007).
Article CAS PubMed Google Scholar
Edogawa, S. et al. Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS. Gut 69, 62–73 (2020).
Article CAS PubMed Google Scholar
de Magistris, L. et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J. Pediatr. Gastroenterol. Nutr. 51, 418–424 (2010).
Hsiao, E. Y. et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155, 1451–1463 (2013).
Article CAS PubMed PubMed Central Google Scholar
Inczefi, O. et al. Targeted intestinal tight junction hyperpermeability alters the microbiome, behavior, and visceromotor responses. Cell Mol. Gastroenterol. Hepatol. 10, 206–208.e3 (2020).
Article CAS PubMed PubMed Central Google Scholar
Farquhar, M. & Palade, G. Junctional complexes in various epithelia. J. Cell Biol. 17, 375–412 (1963).
Article CAS PubMed PubMed Central Google Scholar
Stevenson, B. R., Siliciano, J. D., Mooseker, M. S. & Goodenough, D. A. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J. Cell Biol. 103, 755–766 (1986).
Article CAS PubMed Google Scholar
Stevenson, B. R., Heintzelman, M. B., Anderson, J. M., Citi, S. & Mooseker, M. S. ZO-1 and cingulin: tight junction proteins with distinct identities and localizations. Am. J. Physiol. 257, C621–C628 (1989).
Article CAS PubMed Google Scholar
Jesaitis, L. A. & Goodenough, D. A. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J. Cell Biol. 124, 949–961 (1994).
Article CAS PubMed Google Scholar
Haskins, J., Gu, L., Wittchen, E. S., Hibbard, J. & Stevenson, B. R. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J. Cell Biol. 141, 199–208 (1998).
Article CAS PubMed PubMed Central Google Scholar
Citi, S., Sabanay, H., Jakes, R., Geiger, B. & Kendrick-Jones, J. Cingulin, a new peripheral component of tight junctions. Nature 333, 272–276 (1988).
留言 (0)