Azhibekov T.a· Durodoye R.b· Miller A.K.c· Simpson C.L.d· Davis R.L.e· Williams S.M.b,c· Bruggeman L.A.f

Author affiliations

aDivision of Neonatology, Department of Pediatrics, MetroHealth Medical Center, Cleveland, OH, USA
bDepartment of Populations and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA
cDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA
dDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA
eCenter for Biomedical Informatics, University of Tennessee Health Science Center, Memphis, TN, USA
fDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, USA

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Article / Publication Details

Received: October 25, 2022
Accepted: February 20, 2023
Published online: April 14, 2023

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Background: Hypertensive disorders of pregnancy cause fetal growth restriction and increased maternal morbidity and mortality, especially in women of African ancestry. Recently, preeclampsia risk was associated with polymorphisms in the apolipoprotein L1 (APOL1) gene in women of African ancestry. Objectives: We assessed APOL1 genotype effects on pregnancies with and without preeclampsia. Method: We conducted an unmatched case-control study of 1,358 mother-infant pairs from two independent cohorts of black women. Results: Term preeclampsia cases with high-risk APOL1 genotypes were more likely to be small for gestational age compared to APOL1 low-risk term cases (odds ratio [OR] 2.8) and APOL1 high-risk controls (OR 5.5). Among preterm pregnancies, fetal APOL1 genotype was associated with preeclampsia. Conclusions: Fetal APOL1 genotype was associated with preeclampsia in preterm infants and with altered fetal growth in term infants. This may indicate APOL1 genotype impacts a spectrum of pregnancy complications mediated by a common pathophysiological event of placental insufficiency.

© 2023 S. Karger AG, Basel

References Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222. Obstet Gynecol. 2020;135(6):e237. Davis N, Smooths A, Goodman D. Pregnancy-related deaths: data from 14 U.S. Maternal mortality Review committees, 2008-2017. Atlanta, GA: Centers for Disease Control and Prevention, Department of Health and Human Services; 2019. Nakimuli A, Chazara O, Byamugisha J, Elliott AM, Kaleebu P, Mirembe F, et al. Pregnancy, parturition and preeclampsia in women of African ancestry. Am J Obstet Gynecol. 2014;210(6):510–20.e1. Zhang S, Cardarelli K, Shim R, Ye J, Booker KL, Rust G. Racial disparities in economic and clinical outcomes of pregnancy among medicaid recipients. Matern Child Health J. 2013;17(8):1518–25. Tanaka M, Jaamaa G, Kaiser M, Hills E, Soim A, Zhu M, et al. Racial disparity in hypertensive disorders of pregnancy in New York state: a 10-year longitudinal population-based study. Am J Public Health. 2007;97(1):163–70. Ødegård R, Vatten LJ, Nilsen ST, Salvesen KA, Austgulen R. Preeclampsia and fetal growth. Obstet Gynecol. 2000;96(6):950–5. Barton JR, O’Brien JM, Bergauer NK, Jacques DL, Sibai BM. Mild gestational hypertension remote from term: progression and outcome. Am J Obstet Gynecol. 2001;184(5):979–83. Thakoordeen-Reddy S, Winkler C, Moodley J, David V, Binns-Roemer E, Ramsuran V, et al. Maternal variants within the apolipoprotein L1 gene are associated with preeclampsia in a South African cohort of African ancestry. Eur J Obstet Gynecol Reprod Biol. 2020;246:129–33. Reidy KJ, Hjorten RC, Simpson CL, Rosenberg AZ, Rosenblum SD, Kovesdy CP, et al. Fetal-not maternal-APOL1 genotype associated with risk for preeclampsia in those with african ancestry. Am J Hum Genet. 2018;103(3):367–76. Miller AK, Azhibekov T, O’Toole JF, Sedor JR, Williams SM, Redline RW, et al. Association of preeclampsia with infant APOL1 genotype in African Americans. BMC Med Genet. 2020;21(1):110. Hong X, Rosenberg AZ, Zhang B, Binns-Roemer E, David V, Lv Y, et al. Joint associations of maternal-fetal APOL1 genotypes and maternal country of origin with preeclampsia risk. Am J Kidney Dis. 2021;77(6):879–88.e1. Oken E, Kleinman KP, Rich-Edwards J, Gillman MW. A nearly continuous measure of birth weight for gestational age using a United States national reference. BMC Pediatr. 2003;3:6. Limou S, Nelson GW, Kopp JB, Winkler CA. APOL1 kidney risk alleles: population genetics and disease associations. Adv Chronic Kidney Dis. 2014;21(5):426–33. Robertson CC, Gillies CE, Putler RKB, Ng D, Reidy KJ, Crawford B, et al. An investigation of APOL1 risk genotypes and preterm birth in African American population cohorts. Nephrol Dial Transplant. 2017;32(12):2051–8. Ng DK, Robertson CC, Woroniecki RP, Limou S, Gillies CE, Reidy KJ, et al. APOL1-associated glomerular disease among african-American children: a collaboration of the chronic kidney disease in children (CKiD) and nephrotic syndrome study network (NEPTUNE) cohorts. Nephrol Dial Transplant. 2017;32(6):983–90. Article / Publication Details

Received: October 25, 2022
Accepted: February 20, 2023
Published online: April 14, 2023

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

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