Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement

Abdelwahab S. I., Hassan L. E. A., Sirat H. M., Yagi S. M. A., Koko W. S., Mohan S., Taha M. M. E., Ahmad S., Chuen C. S., Narrima P., Rais M. M., Hadi A. H. A. (2011). Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition. Fitoterapia, 82(8), 1190–1197. https://doi.org/10.1016/j.fitote.2011.08.002

Abdu S., Juaid N., Amin A., Moulay M., Miled N. (2022). Effects of Sorafenib and Quercetin Alone or in Combination in Treating Hepatocellular Carcinoma: In Vitro and In Vivo Approaches. Molecules (Basel, Switzerland), 27(22). https://doi.org/10.3390/molecules27228082

Aguiñiga-Sánchez I., Soto-Hernández M., Cadena-Iñiguez J., Suwalsky M., Colina J. R., Castillo I., Rosado-Pérez J., Mendoza-Núñez V. M., Santiago-Osorio E. (2020). Phytochemical Analysis and Antioxidant and Anti-Inflammatory Capacity of the Extracts of Fruits of the Sechium Hybrid. Molecules (Basel, Switzerland), 25(20). https://doi.org/10.3390/molecules25204637

al Shamsi M., Amin A., Adeghate E. 2006 Vitamin E Ameliorates Some Biochemical Parameters in Normal and Diabetic Rats Ann N. Y. Acad Sci 1084 1 411 431 https://doi.org/10.1196/annals.1372.033

Alafnan A., Alamri A., Hussain T., Rizvi S. M. D. (2022). Cucurbitacin-B Exerts Anticancer Effects through Instigation of Apoptosis and Cell Cycle Arrest within Human Prostate Cancer PC3 Cells via Downregulating JAK/STAT Signaling Cascade. Pharmaceuticals (Basel, Switzerland), 15(10). https://doi.org/10.3390/ph15101229

Al-Akhras M-AH K Aljarrah H Al-Khateeb A Jaradat A Al-omari A Al-Nasser MM Masadeh A Amin A Hamza K Mohammed al Olama, M. Daoud S 2012 Introducing Cichorium Pumilum as a Potential Therapeutical Agent Against Drug-Induced Benign Breast Tumor in Rats Electromagn Biol Med 31 4 299 309 https://doi.org/10.3109/15368378.2012.662193

Al-Dabbagh IA Elhaty C Murali A Madhoon al, & Amin, A. 2018 Salvadora persica (Miswak): Antioxidant and Promising Antiangiogenic Insights Am J Plant Sci 09 06 1228 1244 https://doi.org/10.4236/ajps.2018.96091

Alghasham A. A. (2013). Cucurbitacins - a promising target for cancer therapy. Int J Health Sci 7(1), 77–89. https://doi.org/10.12816/0006025

Amin A, Lotfy M, Mahmoud-Ghoneim D, Adeghate E, Al-Akhras MA, Al-Saadi M, Al-Rahmoun S, Hameed R (2011) Pancreas-protective effects of chlorella in STZ-induced diabetic animal model: insights into the mechanism. J Diabetes Mellitus 01(03):36–45. https://doi.org/10.4236/jdm.2011.13006

Article  Google Scholar 

Andersen J. F., Plattner R. D., Weisleder D. (1988). Metabolic transformations of cucurbitacins by Diabrotica virgifera virgifera leconte and D. undecimpunctata howardi Barber. Insect Biochem 18(1), 71–77. https://doi.org/10.1016/0020-1790(88)90038-8

Arjaibi HM, Ahmed MS, Halaweish FT (2017) Mechanistic investigation of hepato-protective potential for cucurbitacins. Med Chem Res 26(7):1567–1573. https://doi.org/10.1007/s00044-017-1872-3

Article  CAS  Google Scholar 

Atta E. M., Mohamed N. H., Abdelgawad A. A. M. (2017). Antioxidants: An Overview on the Natural and Synthetic Types. Euro Chem Bull 6(8), 365. https://doi.org/10.17628/ecb.2017.6.374-384

Balkema-Boomstra A. G., Zijlstra S., Verstappen F. W. A., Inggamer H., Mercke P. E., Jongsma M. A., & Bouwmeester H. J. (2003). Role of cucurbitacin C in resistance to spider mite (Tetranychus urticae) in cucumber (Cucumis sativus L.). J Chem Ecolog 29(1), 225–235. https://doi.org/10.1023/a:1021945101308

Banerjee S, Byrd JN, Gianino SM, Harpstrite SE, Rodriguez FJ, Tuskan RG, Reilly KM, Piwnica-Worms DR, Gutmann DH (2010) The Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity In vitro and In vivo. Cancer Res 70(4):1356–1366. https://doi.org/10.1158/0008-5472.CAN-09-2178

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banyard J, Bielenberg DR (2015) The role of EMT and MET in cancer dissemination. Connect Tissue Res 56(5):403–413. https://doi.org/10.3109/03008207.2015.1060970

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boykin C, Zhang G, Chen Y-H, Zhang R-W, Fan X-E, Yang W-M, Lu Q (2011) Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. Brit J Cancer 104(5):781–789. https://doi.org/10.1038/bjc.2011.10

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chai Y., Xiang K., Wu Y., Zhang T., Liu Y., Liu X., Zhen W., Si Y. (2018). Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells. Medical Science Monitor : Int Med J Exp Clin Res 24 9251–9258. https://doi.org/10.12659/MSM.911594

Chan KT, Li K, Liu SL, Chu KH, Toh M, Xie WD (2010) Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562. Cancer Lett 289(1):46–52. https://doi.org/10.1016/j.canlet.2009.07.015

Article  CAS  PubMed  Google Scholar 

Chen JC, Chiu MH, Nie RL, Cordell GA, Qiu SX (2005) Cucurbitacins and cucurbitane glycosides: structures and biological activities. Nat Prod Rep 22(3):386–399. https://doi.org/10.1039/b418841c

Article  CAS  PubMed  Google Scholar 

Chen T, Ma B, Lu S, Zeng L, Wang H, Shi W, Zhou L, Xia Y, Zhang X, Zhang J, Chen J (2022) Cucumber-Derived Nanovesicles Containing Cucurbitacin B for Non-Small Cell Lung Cancer Therapy. Int J Nanomed 17:3583–3599. https://doi.org/10.2147/IJN.S362244

Article  Google Scholar 

Chen X, Bao J, Guo J, Ding Q, Lu J, Huang M, Wang Y (2012) Biological activities and potential molecular targets of cucurbitacins. Anti-Cancer Drugs 23(8):777–787. https://doi.org/10.1097/CAD.0b013e3283541384

Article  CAS  PubMed  Google Scholar 

Cheng Y-M, Shen C-J, Chang C-C, Chou C-Y, Tsai C-C, Hsu Y-C (2017) Inducement of apoptosis by cucurbitacin E, a tetracyclic triterpenes, through death receptor 5 in human cervical cancer cell lines. Cell Death Discov 3:17014. https://doi.org/10.1038/cddiscovery.2017.14

Article  PubMed  PubMed Central  Google Scholar 

Dong Y, Lu B, Zhang X, Zhang J, Lai L, Li D, Wu Y, Song Y, Luo J, Pang X, Yi Z, Liu M (2010) Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway. Carcinogenesis 31(12):2097–2104. https://doi.org/10.1093/carcin/bgq167

Article  CAS  PubMed  Google Scholar 

Duangmano S, Sae-Lim P, Suksamrarn A, Domann FE, Patmasiriwat P (2012) Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation. BMC Complement Altern Med 12:185. https://doi.org/10.1186/1472-6882-12-185

Article  CAS  PubMed  PubMed Central  Google Scholar 

EL-Dakhly S. M., Salama A. A. A., Hassanin S. O. M., Yassen N. N., Hamza A. A., Amin A. 2020 Aescin and diosmin each alone or in low dose- combination ameliorate liver damage induced by carbon tetrachloride in rats BMC Res Notes 13 1 259 https://doi.org/10.1186/s13104-020-05094-2

Gao Y, Islam MS, Tian J, Lui VWY, Xiao D (2014) Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth. Cancer Lett 349(1):15–25. https://doi.org/10.1016/j.canlet.2014.03.015

Article  CAS  PubMed  Google Scholar 

Garg S, Kaul S, Wadhwa R (2017) Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review). Int J Oncol. https://doi.org/10.3892/ijo.2017.4203

Article  PubMed  Google Scholar 

Guo J., Wu G., Bao J., Hao W., Lu J., Chen X. (2014). Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. PloS One, 9(2), e88140. https://doi.org/10.1371/journal.pone.0088140

Gupta P., Srivastava S. K. (2014). Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression. Oncotarget, 5(7), 1812–1828. https://doi.org/10.18632/oncotarget.1743

Hamza AA, Gamel M, Abdalla A, Abdalla Y, Amin A (2023) Gentiana lutea attenuates hepatotoxicity induced by ketoconazole in rats by fortifying the cellular antioxidant defense system. J Basic Appl Zool 84(1):1. https://doi.org/10.1186/s41936-022-00321-7

Article  CAS  Google Scholar 

Hamza AA, Lashin FM, Gamel M, Hassanin SO, Abdalla Y, Amin A (2020) Hawthorn Herbal Preparation from Crataegus oxyacantha Attenuates In Vivo Carbon Tetrachloride -Induced Hepatic Fibrosis via Modulating Oxidative Stress and Inflammation. Antioxidants 9(12):1173. https://doi.org/10.3390/antiox9121173

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamza AA, Mohamed MG, Lashin FM, Amin A (2020) Dandelion prevents liver fibrosis, inflammatory response, and oxidative stress in rats. J Basic Appl Zool 81(1):43. https://doi.org/10.1186/s41936-020-00177-9

Article  Google Scholar 

Haritunians T, Gueller S, Zhang L, Badr R, Yin D, Xing H, Fung MC, Koeffler HP (2008) Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. Leuk Res 32(9):1366–1373. https://doi.org/10.1016/j.leukres.2008.01.019

Article  CAS  PubMed  Google Scholar 

He J., Wang Y., Xu L., Qiao J., Ouyang D., He X. (2013). Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages. Int Immunopharmacol, 16(1), 27–34. https://doi.org/10.1016/j.intimp.2013.03.013

SE Hernández Navia JL Figueroa-Hernández JS Rodríguez-Zavala M Rodriguez-Sosa M Martínez-Vázquez 2022 Anti-Diabetic Effects of Cucurbitacins from Ibervillea lindheimeri on Induced Mouse Diabetes J Chem 1 15 https://doi.org/10.1155/2022/3379557

Hsu H-S, Huang P-I, Chang Y-L, Tzao C, Chen Y-W, Shih H-C, Hung S-C, Chen Y-C, Tseng L-M, Chiou S-H (2011) Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells. Cancer 117(13):2970–2985. https://doi.org/10.1002/cncr.25869

Article  CAS  PubMed  Google Scholar 

Huang W.-W., Yang J.-S., Lin M.-W., Chen P.-Y., Chiou S.-M., Chueh F.-S., Lan Y.-H., Pai S.-J., Tsuzuki M., Ho W.-J., Chung J.-G. (2012). Cucurbitacin E Induces G(2)/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells. Evid.-Based Complement. Altern. Med : ECAM 952762. https://doi.org/10.1155/2012/952762

Hunsakunachai N., Nuengchamnong N., Jiratchariyakul W., Kummalue T., Khemawoot P. (2019). Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats. BMC Complement Altern Med, 19(1), 157. https://doi.org/10.1186/s12906-019-2568-7

Ishdorj G, Johnston JB, Gibson SB (2010) Inhibition of Constitutive Activation of STAT3 by Curcurbitacin-I (JSI-124) Sensitized Human B-Leukemia Cells to Apoptosis. Mol Cancer Ther 9(12):3302–3314. https://doi.org/10.1158/1535-7163.MCT-10-0550

Article  CAS  PubMed  Google Scholar 

Ishii T, Kira N, Yoshida T, Narahara H (2013) Cucurbitacin D induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial and ovarian cancer cells. Tumour Biol : J Int Soc Oncodev. Biol Med 34(1):285–291. https://doi.org/10.1007/s13277-012-0549-2

Article  CAS  Google Scholar 

Iwanski GB, Lee DH, En-Gal S, Doan NB, Castor B, Vogt M, Toh M, Bokemeyer C, Said JW, Thoennissen NH, Koeffler HP (2010) Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer. Br J Pharmacol 160(4):998–1007. https://doi.org/10.1111/j.1476-5381.2010.00741.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaewmeesri P, Pocasap P, Kukongviriyapan V, Prawan A, Kongpetch S, Senggunprai L (2022) Anti-metastatic Potential of Natural Triterpenoid Cucurbitacin B Against Cholangiocarcinoma Cells by Targeting Src Protein. Int Cancer Therap 21:15347354221124860. https://doi.org/10.1177/15347354221124861

Article  CAS  Google Scholar 

Kapoor N., Ghorai S. M., Kushwaha P. K., Shukla R., Aggarwal C., Bandichhor R. (2020). Plausible mechanisms explaining the role of cucurbitacins as potential therapeutic drugs against coronavirus 2019. Inform Med Unlocked 21, 100484. https://doi.org/10.1016/j.imu.2020.100484

Kausar H  Munagala R Bansal SS Aqil F Vadhanam Mv, Gupta R. C. 2013 Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets Cancer Lett 332 1 35 45 https://doi.org/10.1016/j.canlet.2013.01.008

Kim HJ, Kim J-K (2015) Antiangiogenic effects of cucurbitacin-I. Arch Pharm Res 38(2):290–298. https://doi.org/10.1007/s12272-014-0386-5

Article  CAS  PubMed  Google Scholar 

Kim HJ, Park JHY, Kim J-K (2014) Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer. Chem-Biol Int 219:1–8. https://doi.org/10.1016/j.cbi.2014.05.005

Article  CAS  Google Scholar 

Li Y, Wang R, Ma E, Deng Y, Wang X, Xiao J, Jing Y (2010) The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2alpha in leukemia cells. Anti-Cancer Drugs 21(4):389–400. https://doi.org/10.1097/CAD.0b013e328336b383

Article  CAS  PubMed  Google Scholar 

Liang Y., Zhang T., Ren L., Jing S., Li Z., Zuo P., Li T., Wang Y., Zhang J., Wei Z. (2021). Cucurbitacin IIb induces apoptosis and cell cycle arrest through regulating EGFR/MAPK pathway. Environ Toxicol Pharmacol 81, 103542. https://doi.org/10.1016/j.etap.2020.103542

Liu J., Liu X., Ma W., Kou W., Li C., Zhao J. (2018). Anticancer activity of cucurbitacin-A in ovarian cancer cell line SKOV3 involves cell cycle arrest, apoptosis and inhibition of mTOR/PI3K/Akt signaling pathway. J B.U.ON. : Off J Balkan Union Oncol 23(1), 124–128.

Liu J-H, Li C, Cao L, Zhang C-H, Zhang Z-H (2022) Cucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6/STAT3 pathway through the lncRNA XIST/miR-let-7c axis. Pharmaceutic Biol 60(1):154–162. https://doi.org/10.1080/13880209.2021.2016866

Article  CAS  Google Scholar 

Liu P., Xiang Y., Liu X., Zhang T., Yang R., Chen S., Xu L., Yu Q., Zhao H., Zhang L., Liu Y., Si Y. (2019). Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer. Molecules (Basel, Switzerland), 24(3). https://doi.org/10.3390/molecules24030647

Liu T, Peng H, Zhang M, Deng Y, Wu Z (2010) Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin. Eur J Pharmacol 641(1):15–22. https://doi.org/10.1016/j.ejphar.2010.04.062

Article  CAS  PubMed 

留言 (0)

沒有登入
gif