• Virani SS, Alonso A, Benjamin EJ, et al. Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation. 2020;141:e139–596. This report reflects the overall poor survival rate of OHCA despite recent therapeutic advances, and sets the tone for the need for further investigation into all therapeutic modalities.Association of timing of epinephrine administration with outcomes

• Okubo M, Komukai S, Callaway CW, et al. Association of timing of epinephrine administration with outcomes in adults with out-of-hospital cardiac arrest. JAMA Netw Open. 2021;4(8):e2120176. This is a large retrospective study with data derived from the Resuscitation Outcomes Consortium Cardiac Epidemiologic Registry. 

Article  PubMed  PubMed Central  Google Scholar 

• Hsieh Y, Wu M, Wolfshohl J, et al. Intraosseous versus intravenous vascular access during cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of observational studies. Scand J Trauma Resusc Emerg Med. 2021;29(44):1–12. This is a previous systematic review (April 2020) that included nine retrospective observational studies and 111,746 patients. 

• Granfeldt A, Avis SR, Lind PC, et al. Intravenous vs. intraosseous administration of drugs during cardiac arrest: a systematic review. Resuscitation. 2020;149:150–7. This is a previous systematic review (December 2019) including 6 retrospective studies.

• Morales-Cane I, Valverde-Leon MDR, Rodriguez-Borrego MA, et al. Intraosseous access in adults in cardiac arrest: a systemic review and meta-analysis. Emergencias. 2020;32(1):49–56. This is a previous systematic review (May 2019) which included 5 studies in the meta-analysis.

Aeschbacher G, Webb AI. Intraosseous injection during cardio-pulmonary resuscitation in dogs. J Small Anim Pract. 1993;34:629–33.

Article  Google Scholar 

Davy RB, Buckley GJ, Shih A. The effect of catheter location and flush volume on the time for contrast to reach the heart in a porcine model of cardiac arrest. J Vet Emerg Crit Care. 2017;27(S1):S20.

Google Scholar 

Fiallos M, Kissoon N, Abdelmoneim T, et al. Fat embolism with use of intraosseous infusion during cardiopulmonary resuscitation. Am J Med Sci. 1997;314(2):73–9.

CAS  PubMed  Google Scholar 

Hoskins SL, Nascimento PD Jr, Lima RM, Espana-Tenorio JM, Kramer GC. Pharmacokinetics of intraosseous and central venous drug delivery during cardiopulmonary resuscitation. Resuscitation. 2012;83:107–12.

Article  CAS  PubMed  Google Scholar 

Redmond AD, Plunkett PK. Intraosseous infusion. Arch Emerg Med. 1986;3:231–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andropoulos DB, Solfer SJ, Schreiber MD. Plasma epinephrine concentrations after intraosseous and central venous injection during cardiopulmonary resuscitation in the lamb. J Pediatr. 1990;116(2):312–5.

Article  CAS  PubMed  Google Scholar 

Roberts CT, Klink S, Schmolzer GM, et al. Comparison of intraosseous and intravenous epinephrine administration during resuscitation of asphyxiated newborn lambs. Arch Dis Child Fetal Neonatal Ed. 2022;107:F311–6. https://doi.org/10.1136/archdischild-2021-322638.

Article  Google Scholar 

Beaumont D, Baragchizadeh A, Johnson C, Johnson D. Effects of tibial and humerus intraosseous administration of epinephrine in a cardiac arrest swine model. Am J Disaster Med. 2016;11(4):243–51.

Article  PubMed  Google Scholar 

Johnson D, Garcia-Blanco J, Burgert J, et al. Effects of humeral intraosseous versus intravenous epinephrine on pharmacokinetics and return of spontaneous circulation in a porcine cardiac arrest model: a randomized control trial. Ann Med Surg. 2015;4:306–10.

Article  Google Scholar 

Wong MR, Reggio MJ, Morocho FR, et al. Effects of intraosseous epinephrine in a cardiac arrest swine model. J Surg Res. 2016;201:327–33.

Article  CAS  PubMed  Google Scholar 

Burgert JM, Johnson AD, O’Sullivan JC, et al. Pharmacokinetic effects of endotracheal, intraosseous, and intravenous epinephrine in a swine model of traumatic cardiac arrest. Am J Emerg Med. 2019;37:2043–50.

Article  PubMed  Google Scholar 

Burgert J, Gegel B, Loughren M, et al. Comparison of tibial intraosseous, sternal intraosseous, and intravenous routes of administration on pharmacokinetics of epinephrine during cardiac arrest: a pilot study. Am Assoc Nurse Anesth J. 2012;80(4):6–10.

Google Scholar 

Long RP, Gardner SM, Burgert J, et al. Humerus intraosseous administration of epinephrine in normovolemic and hypovolemic porcine model. Am J Disaster Med. 2018;13(2):97–106.

Article  PubMed  Google Scholar 

Yauger YJ, Johnson MD, Mark J, et al. Intraosseous administration of epinephrine is effective in restoring return of spontaneous circulation in a pediatric normovolemic but not hypovolemic cardiac arrest model. Pediatr Emerg Care. 2020;00:1–7.

Google Scholar 

Neill MJ, Burgert JM, Blouin D, et al. Effects of humeral intraosseous epinephrine in a pediatric hypovolemic cardiac arrest porcine model. Trauma Surg Acute Care Open. 2020;5:1–6.

Article  Google Scholar 

Spivey WH, Crespo SG, Fuhs LR, Schoffstall JM. Plasma catecholamine levels after intraosseous epinephrine administration in a cardiac arrest model. Ann Emerg Med. 1992;21(2):127–31.

Article  CAS  PubMed  Google Scholar 

Wenzel V, Lindner KH, Augenstein S, et al. Intraosseous vasopressin improves coronary perfusion pressure rapidly during cardiopulmonary resuscitation in pigs. Crit Care Med. 1999;27(8):1565–9.

Article  CAS  PubMed  Google Scholar 

Panchal AR, Bartos JA, Cabanas JG, et al. Part 3: Adult basic and advanced life support. 2020 American Heart Association guidelines for cardiopulmonary and emergency cardiovascular care. Circulation. 2020;142(Suppl2):S366–468.

PubMed  Google Scholar 

Adams TS, Blouin D, Johnson D. Effects of tibial and humerus intraosseous and intravenous vasopressin in porcine cardiac arrest model. Am J Disaster Med. 2016;11(3):211–8.

Article  PubMed  Google Scholar 

Burgert JM, Johnson AD, Garcia-Blanco J, Fulton LV, Loughren MJ. The resuscitative and pharmacokinetic effects of humeral intraosseous vasopressin in a swine model of ventricular fibrillation. Prehosp Disaster Med. 2017;32(3):305–10.

Article  PubMed  Google Scholar 

Fulkerson J, Lowe R, Anderson T, Moore H, Craig W, Johnson D. Effects of intraosseous tibial vs. intravenous vasopressin in a hypovolemic cardiac arrest model. West J Emerg Med. 2016;17(2):222–8.

Article  PubMed  PubMed Central  Google Scholar 

Johnson D, Giles K, Acuna A, Saenz C, Bentley M, Budinich C. Effects of tibial intraosseous and IV administration of vasopressin on kinetics and survivability in cardiac arrest. Am J Emerg Med. 2016;34:429–32.

Article  PubMed  Google Scholar 

Vallier DJ, Torrence AD, Stevens R, Arcinue PN, Johnson D. The effects of sternal and intravenous vasopressin administration on pharmacokinetics. Am J Disaster Med. 2016;11(3):203–9.

Article  PubMed  Google Scholar 

Wimmer MH, Heffner K, Smithers M, et al. The comparison of humeral intraosseous and intravenous administration of vasopressin on return of spontaneous circulation and pharmacokinetics in a hypovolemic cardiac arrest swine model. Am J Disaster Med. 2016;11(4):237–42.

Article  PubMed  Google Scholar 

Burgert JM, Martinez A, O’Sullivan M, Blouin D, Long A, Johnson AD. Sternal route more effective than tibial route for intraosseous amiodarone administration in a swine model of ventricular fibrillation. Prehosp Emerg Care. 2018;22(2):266–75.

Article  PubMed  Google Scholar 

Smith S, Borgkvist B, Kist T, Annelin J, Johnson D, Long R. The effects of sternal intraosseous and intravenous administration of amiodarone in a hypovolemic swine cardiac arrest model. Am J Disaster Med. 2016;11(4):271–7.

Article  PubMed  Google Scholar 

Hampton K, Wang E, Argame JI, Bateman T, Craig W, Johnson D. The effects of tibial intraosseous versus intravenous amiodarone administration in a hypovolemic cardiac arrest procaine model. Am J Disaster Med. 2016;11(4):253–60.

Article  PubMed  Google Scholar 

Holloway MM, Jurina SL, Orszag JD, et al. Effects of humerus intraosseous versus intravenous amiodarone administration in a hypovolemic porcine model. Am J Disaster Med. 2016;11(4):261–9.

Article  PubMed  Google Scholar 

Lathers CM, Jim KF, High WB, Spivey WH, Matthews WD, Ho T. An investigation of the pathological and physiological effects of intraosseous sodium bicarbonate in pigs. J Clin Pharmacol. 1989;29(4):354–9.

Article  CAS  PubMed  Google Scholar 

Spivey WH, Lathers CM, Malone DR, et al. Comparison of intraosseous, central, and peripheral routes of sodium bicarbonate administration during CPR in pigs. Ann Emerg Med. 1985;14(2):1135–40.

Article  CAS  PubMed  Google Scholar 

Youngquist ST, Heyming T, Rosborough JP, et al. Hypocalcemia following resuscitation from cardiac arrest revisited. Resuscitation. 2010;81(1):117.

Article  CAS  PubMed  Google Scholar 

Andersen LW, Holmberg MJ, Granfeldt A, et al. Calcium administration and post-cardiac arrest ionized calcium values according to intraosseous or intravenous administration-a post hoc analysis of a randomized trial. Resuscitation. 2022;170:211–2.

Article  PubMed  Google Scholar 

Ruiz-Hornillos PJ, Martínez-Cámara F, Elizondo M. Systemic fibrinolysis through intraosseous vascular access in st-segment elevation myocardial infarction. Ann Emerg Med. 2011;57(6):572–4.

Article  PubMed  Google Scholar 

Valdes M, Araujo P, de Andres C, Sastre E, Martin T. Intraosseous administration of thrombolysis in out-of-hospital massive pulmonary thromboembolism. Emerg Med J. 2010;27(8):641–4.

Article  PubMed  Google Scholar 

Northey LC, Shiraev T, Omari A. Salvage intraosseous thrombolysis and extracorporeal membrane oxygenation for massive pulmonary embolism. J Emerg Trauma Shock. 2015;8(1):55–7.

Article  PubMed  PubMed Central  Google Scholar 

Landy C, Plancade D, Gagnon N, Schaeffer E, Nadaud J, Favier J. Complication of intraosseous administration of systemic fibrinolysis for a massive pulmonary embolism with cardiac arrest. Resuscitation. 2012;83:149–50.

Article  Google Scholar 

Abdelmoneim T, Kissoon N, Johnson L, Fiallos M, Murphy S. Acid-base status of blood from intraosseous and mixed venous sites during prolonged cardiopulmonary resuscitation and drug infusions. Crit Care Med. 1999;27(9):1923–8.

Article  CAS  PubMed  Google Scholar 

Kissoon N, Rosenberg H, Gloor J, Vidal R. Comparison of the acid-base status of blood obtained from intraosseous and central venous sites during steady- and low-flow states. Crit Care Med. 1993;21(11):1765–9.

Article  CAS