Clear Cell Renal Cell Carcinoma: A Comprehensive in Silico Study in Searching for Therapeutic Targets
Kidney and Blood Pressure Research
Abstract
Introduction: Clear cell renal cell carcinoma is recognized as one of the leading causes of illness and death worldwide. Understanding the molecular mechanisms in clear cell renal cell carcinoma pathogenesis is crucial for discovering novel therapeutic targets and developing efficient drugs. With the application of a comprehensive in silico analysis of the clear cell renal cell carcinoma-related array sets, the main objective of this study was to discover the top molecules and pathways in the pathogenesis of this cancer.
Methods: Clear cell renal cell carcinoma microarray datasets were downloaded from the Gene Expression Omnibus database, and after quality checking, normalization, and analysis using the Limma algorithm, differentially expressed genes (DEGs) were identified, considering the adjusted p-value
The Author(s). Published by S. Karger AG, Basel
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