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Kidney and Blood Pressure Research
Research Article
Xu Y. · Yang J. · Lu F. · Ye C. · Wang C.
Introduction: Chronic hypoxia is prevalent in chronic kidney disease (CKD), and Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) provides noninvasive evaluation of renal oxygenation. This study aimed to explore the correlation of renal oxygenation evaluated by BOLD-MRI with renal function. Methods: 97 non-dialysis patients with CKD stages 1-5 and healthy volunteers (HVs) were recruited in the study. Based on their estimated glomerular filtration rate (eGFR), the patients were divided into two groups: CKD stages 1-3 (CKD 1-3) and CKD stages 4-5 (CKD 4-5) . We measured cortical and medullary T2* (COT2* and MET2*) values in all participants by BOLD-MRI. Physiological indices were also recorded and compared among three groups. Correlation of T2* values with clinical characteristics were determined. Results: The COT2* values were significantly higher than MET2* values in all participants. The COT2* and MET2* values of three groups were ranked as HV> CKD 1-3> CKD 4-5 (p 0.4, p 0.05). Urinary microprotein, including urinary alpha1-microglobulin (α1-MG), urinary beta2-microglobulin (β2-MG), and urinary retinol binding protein (RBP), was showed strong correlation with COT2* and MET2* values. According to analysis of receiver-operating characteristic (ROC) curve, we obtained the optimal cut-point between HV and CKD 1-3 were “
The Author(s). Published by S. Karger AG, Basel
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