Cancer-Related Increases and Decreases in Calcium Signaling at the Endoplasmic Reticulum-Mitochondria Interface (MAMs)

Abu-Hamad S, Arbel N, Calo D, Arzoine L, Israelson A, Keinan N, Ben-Romano R, Friedman O, Shoshan-Barmatz V (2009) The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins. J Cell Sci 122(Pt 11):1906–1916. https://doi.org/10.1242/jcs.040188

CrossRef  CAS  Google Scholar 

Akl H, Bultynck G (2013) Altered Ca(2+) signaling in cancer cells: proto-oncogenes and tumor suppressors targeting IP3 receptors. Biochim Biophys Acta 1835(2):180–193. https://doi.org/10.1016/j.bbcan.2012.12.001

CrossRef  CAS  Google Scholar 

Alonso MT, Manjarres IM, Garcia-Sancho J (2009) Modulation of calcium signalling by intracellular organelles seen with targeted aequorins. Acta Physiol (Oxf) 195(1):37–49. https://doi.org/10.1111/j.1748-1716.2008.01920.x

CrossRef  CAS  Google Scholar 

Anelli T, Bergamelli L, Margittai E, Rimessi A, Fagioli C, Malgaroli A, Pinton P, Ripamonti M, Rizzuto R, Sitia R (2012) Ero1alpha regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM). Antioxid Redox Signal 16(10):1077–1087. https://doi.org/10.1089/ars.2011.4004

CrossRef  CAS  Google Scholar 

Antony AN, Paillard M, Moffat C, Juskeviciute E, Correnti J, Bolon B, Rubin E, Csordas G, Seifert EL, Hoek JB, Hajnoczky G (2016) MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. Nat Commun 7:10955. https://doi.org/10.1038/ncomms10955

CrossRef  CAS  Google Scholar 

Arbel N, Shoshan-Barmatz V (2010) Voltage-dependent anion channel 1-based peptides interact with Bcl-2 to prevent antiapoptotic activity. J Biol Chem 285(9):6053–6062. https://doi.org/10.1074/jbc.M109.082990

CrossRef  CAS  Google Scholar 

Ashby MC, Tepikin AV (2001) ER calcium and the functions of intracellular organelles. Semin Cell Dev Biol 12(1):11–17. https://doi.org/10.1006/scdb.2000.0212

CrossRef  CAS  Google Scholar 

Avalle L, Camporeale A, Morciano G, Caroccia N, Ghetti E, Orecchia V, Viavattene D, Giorgi C, Pinton P, Poli V (2019) STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca(2+) fluxes and apoptotic responses. Cell Death Differ 26(5):932–942. https://doi.org/10.1038/s41418-018-0171-y

CrossRef  CAS  Google Scholar 

Bansaghi S, Golenar T, Madesh M, Csordas G, RamachandraRao S, Sharma K, Yule DI, Joseph SK, Hajnoczky G (2014) Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species. J Biol Chem 289(12):8170–8181. https://doi.org/10.1074/jbc.M113.504159

CrossRef  CAS  Google Scholar 

Bargaje R, Gupta S, Sarkeshik A, Park R, Xu T, Sarkar M, Halimani M, Roy SS, Yates J, Pillai B (2012) Identification of novel targets for miR-29a using miRNA proteomics. PLoS One 7(8):e43243. https://doi.org/10.1371/journal.pone.0043243

CrossRef  CAS  Google Scholar 

Bartok A, Weaver D, Golenar T, Nichtova Z, Katona M, Bansaghi S, Alzayady KJ, Thomas VK, Ando H, Mikoshiba K, Joseph SK, Yule DI, Csordas G, Hajnoczky G (2019) IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer. Nat Commun 10(1):3726. https://doi.org/10.1038/s41467-019-11646-3

CrossRef  CAS  Google Scholar 

Bartoszewska S, Collawn JF (2020) Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia. Cell Mol Biol Lett 25:18. https://doi.org/10.1186/s11658-020-00212-1

CrossRef  CAS  Google Scholar 

Bathori G, Csordas G, Garcia-Perez C, Davies E, Hajnoczky G (2006) Ca2+−dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC). J Biol Chem 281(25):17347–17358. https://doi.org/10.1074/jbc.M600906200

CrossRef  CAS  Google Scholar 

Bernardi R, Pandolfi PP (2007) Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol 8(12):1006–1016. https://doi.org/10.1038/nrm2277

CrossRef  CAS  Google Scholar 

Bernard-Marissal N, Chrast R, Schneider BL (2018) Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship? Cell Death Dis 9(3):333. https://doi.org/10.1038/s41419-017-0125-1

CrossRef  Google Scholar 

Berridge MJ (2012) Calcium signalling remodelling and disease. Biochem Soc Trans 40(2):297–309. https://doi.org/10.1042/BST20110766

CrossRef  CAS  Google Scholar 

Berridge MJ, Bootman MD, Roderick HL (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4(7):517–529. https://doi.org/10.1038/nrm1155

CrossRef  CAS  Google Scholar 

Betz C, Stracka D, Prescianotto-Baschong C, Frieden M, Demaurex N, Hall MN (2013) Feature article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proc Natl Acad Sci U S A 110(31):12526–12534. https://doi.org/10.1073/pnas.1302455110

CrossRef  Google Scholar 

Betzenhauser MJ, Wagner LE 2nd, Iwai M, Michikawa T, Mikoshiba K, Yule DI (2008) ATP modulation of Ca2+ release by type-2 and type-3 inositol (1, 4, 5)-triphosphate receptors. Differing ATP sensitivities and molecular determinants of action. J Biol Chem 283(31):21579–21587. https://doi.org/10.1074/jbc.M801680200

CrossRef  CAS  Google Scholar 

Bittremieux M, Parys JB, Pinton P, Bultynck G (2016) ER functions of oncogenes and tumor suppressors: modulators of intracellular Ca(2+) signaling. Biochim Biophys Acta 1863(6 Pt B):1364–1378. https://doi.org/10.1016/j.bbamcr.2016.01.002

CrossRef  CAS  Google Scholar 

Bittremieux M, La Rovere RM, Akl H, Martines C, Welkenhuyzen K, Dubron K, Baes M, Janssens A, Vandenberghe P, Laurenti L, Rietdorf K, Morciano G, Pinton P, Mikoshiba K, Bootman MD, Efremov DG, De Smedt H, Parys JB, Bultynck G (2019) Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2. Cell Death Differ 26(3):531–547. https://doi.org/10.1038/s41418-018-0142-3

CrossRef  CAS  Google Scholar 

Bononi A, Bonora M, Marchi S, Missiroli S, Poletti F, Giorgi C, Pandolfi PP, Pinton P (2013) Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Differ 20(12):1631–1643. https://doi.org/10.1038/cdd.2013.77

CrossRef  CAS  Google Scholar 

Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P, Carbone M (2017) BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation. Nature 546(7659):549–553. https://doi.org/10.1038/nature22798

CrossRef  CAS  Google Scholar 

Bonora M, Morganti C, Morciano G, Pedriali G, Lebiedzinska-Arciszewska M, Aquila G, Giorgi C, Rizzo P, Campo G, Ferrari R, Kroemer G, Wieckowski MR, Galluzzi L, Pinton P (2017) Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation. EMBO Rep 18(7):1077–1089. https://doi.org/10.15252/embr.201643602

CrossRef  CAS  Google Scholar 

Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, Jaenisch R (2006) Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441(7091):349–353. https://doi.org/10.1038/nature04733

CrossRef  CAS  Google Scholar 

Brocchieri L, Conway de Macario E, Macario AJ (2008) hsp70 genes in the human genome: conservation and differentiation patterns predict a wide array of overlapping and specialized functions. BMC Evol Biol 8:19. https://doi.org/10.1186/1471-2148-8-19

CrossRef  CAS  Google Scholar 

Buck TM, Wright CM, Brodsky JL (2007) The activities and function of molecular chaperones in the endoplasmic reticulum. Semin Cell Dev Biol 18(6):751–761. https://doi.org/10.1016/j.semcdb.2007.09.001

CrossRef  CAS  Google Scholar 

Cai X, Wang X, Patel S, Clapham DE (2015) Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view. Cell Calcium 57(3):166–173. https://doi.org/10.1016/j.ceca.2014.11.007

CrossRef  CAS  Google Scholar 

Campbell KJ, Dhayade S, Ferrari N, Sims AH, Johnson E, Mason SM, Dickson A, Ryan KM, Kalna G, Edwards J, Tait SWG, Blyth K (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death Dis 9(2):19. https://doi.org/10.1038/s41419-017-0035-2

CrossRef  CAS  Google Scholar 

Carafoli E (2002) Calcium signaling: a tale for all seasons. Proc Natl Acad Sci U S A 99(3):1115–1122. https://doi.org/10.1073/pnas.032427999

CrossRef  CAS  Google Scholar 

Carafoli E, Krebs J (2016) Why calcium? How calcium became the best communicator. J Biol Chem 291(40):20849–20857. https://doi.org/10.1074/jbc.R116.735894

CrossRef  CAS  Google Scholar 

Cardenas C, Muller M, McNeal A, Lovy A, Jana F, Bustos G, Urra F, Smith N, Molgo J, Diehl JA, Ridky TW, Foskett JK (2016) Selective vulnerability of cancer cells by inhibition of Ca(2+) transfer from endoplasmic reticulum to mitochondria. Cell Rep 14(10):2313–2324. https://doi.org/10.1016/j.celrep.2016.02.030

CrossRef  CAS  Google Scholar 

Carpi S, Polini B, Poli G, Alcantara Barata G, Fogli S, Romanini A, Tuccinardi T, Guella G, Frontini FP, Nieri P, Di Giuseppe G (2018) Anticancer activity of Euplotin C, isolated from the marine ciliate Euplotes crassus, against human melanoma cells. Mar Drugs 16(5). https://doi.org/10.3390/md16050166

Chaudhuri AD, Choi DC, Kabaria S, Tran A, Junn E (2016a) MicroRNA-7 regulates the function of mitochondrial permeability transition pore by targeting VDAC1 expression. J Biol Chem 291(12):6483–6493. https://doi.org/10.1074/jbc.M115.691352

CrossRef  CAS  Google Scholar 

Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE (2016b) Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition. Proc Natl Acad Sci U S A 113(13):E1872–E1880. https://doi.org/10.1073/pnas.1602264113

CrossRef  CAS  Google Scholar 

Chen Q, Xu H, Xu A, Ross T, Bowler E, Hu Y, Lesnefsky EJ (2015) Inhibition of Bcl-2 sensitizes mitochondrial permeability transition pore (MPTP) opening in ischemia-damaged mitochondria. PLoS One 10(3):e0118834. https://doi.org/10.1371/journal.pone.0118834

CrossRef  CAS  Google Scholar 

Chen G, Park D, Magis AT, Behera M, Ramalingam SS, Owonikoko TK, Sica GL, Ye K, Zhang C, Chen Z, Curran WJ, Deng X (2019) Mcl-1 interacts with Akt to promote lung cancer progression. Cancer Res 79(24):6126–6138. https://doi.org/10.1158/0008-5472.CAN-19-0950

CrossRef  CAS  Google Scholar 

Colombini M (2012) VDAC structure, selectivity, and dynamics. Biochim Biophys Acta 1818(6):1457–1465. https://doi.org/10.1016/j.bbamem.2011.12.026

CrossRef  CAS  Google Scholar 

Cosentino K, Garcia-Saez AJ (2014) Mitochondrial alterations in apoptosis. Chem Phys Lipids 181:62–75. https://doi.org/10.1016/j.chemphyslip.2014.04.001

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