Exercise by Shaking Alleviates the Decline in Memory due to Aging: A Study in Mice

Dementia and Geriatric Cognitive Disorders

Izawa S.a· Yamada K.a· Yao R.a,c· Aizu N.a· Kito T.a,d· Iwata D.a· Chihara T.b· Sawada H.b· Nishii K.a

Author affiliations

aGraduate School of Health Sciences, Fujita Health University, Toyoake, Japan
bDepartment of Medical Technology, School of Nursing and Medical Care, Yokkaichi Nursing and Medical Care University, Yokkaichi, Japan
cDepartment of Physical Therapy, School of Health Sciences, Japan University of Health Sciences, Satte, Japan
dDepartment of Physical Therapy, Faculty of Health Sciences, Kinjo University, Hakusan, Japan

Dement Geriatr Cogn Disord

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Article / Publication Details

First-Page Preview

Abstract of Research Article

Received: June 03, 2022
Accepted: August 07, 2022
Published online: December 14, 2022

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Introduction: Although exercise can prevent cognitive decline due to aging, few elderly individuals are able to exercise for long. Therefore, an exercise method for older adults that is feasible for a long duration without overexertion is necessary. In this study, we focused on exercise by shaking. This study examined the possibility to prevent the decline in memory through regular and long-term shaking exercise using a senescence-accelerated mouse (SAM) model. Behavioral analysis was conducted, and histological changes in the mouse brain were examined to evaluate whether this stimulation method could become a novel exercise method. Materials and Methods: The shaking exercise was applied to SAMP10 mice for 30 min 3 times per week for 25 continuous weeks. Behavioral analysis included a step-through passive avoidance test, whereas the histological analysis involved immunohistochemical staining using the anti-glutamate receptor (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors [AMPAR]) antibody in the hippocampus. The number and area of nerve cells in the hippocampal regions were measured and compared between groups. Results: Behavioral analysis revealed that the shaking group retained memory longer than the control group, and memory capacity decline was suppressed. Additionally, histological examination showed that the shaking group had a higher number of AMPAR receptor-positive neurons per area in the hippocampal CA1 and CA3 regions than the control group, suggesting that degeneration and shedding of neurons due to aging was suppressed. Discussion/Conclusion: We believe that shaking could become an exercise therapy that can reduce the decline in memory with aging and expect its human application in the future.

© 2022 S. Karger AG, Basel

References Harada CN, Natelson Love MC, Triebel KL. Normal cognitive aging. Clin Geriatr Med. 2013 Nov;29(4):737–52. Teubner-Rhodes S, Vaden KI Jr, Cute SL, Yeatman JD, Dougherty RF, Eckert MA. Aging-resilient associations between the arcuate fasciculus and vocabulary knowledge: microstructure or morphology? J Neurosci. 2016 Jul 6;36(27):7210–22. Moscoso Del Prado Martín F. Vocabulary, grammar, sex, and aging. Cogn Sci. 2017 May;41(4):950–75. Zahr NM, Rohlfing T, Pfefferbaum A, Sullivan EV. Problem solving, working memory, and motor correlates of association and commissural fiber bundles in normal aging: a quantitative fiber tracking study. Neuroimage. 2009 Feb;44(3):1050–62. Nyberg L, Lövdén M, Riklund K, Lindenberger U, Bäckman L. Memory aging and brain maintenance. Trends Cogn Sci. 2012 May;16(5):292–305. Salthouse TA. Aging and measures of processing speed. Biol Psychol. 2000 Oct;54(1–3):35–54. Shanmugaratnam S, Kass SJ, Arruda JE. Age differences in cognitive and psychomotor abilities and simulated driving. Accid Anal Prev. 2010 May;42(3):802–8. Mitchell SJ, Scheibye-Knudsen M, Longo DL, de Cabo R. Animal models of aging research: implications for human aging and age-related diseases. Annu Rev Anim Biosci. 2015;3(1):283–303. Terribilli D, Schaufelberger MS, Duran FLS, Zanetti MV, Curiati PK, Menezes PR, et al. Age-related gray matter volume changes in the brain during non-elderly adulthood. Neurobiol Aging. 2011 Feb;32(2):354–68. Apostolova LG, Green AE, Babakchanian S, Hwang KS, Chou YY, Toga AW, et al. Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease. Alzheimer Dis Assoc Disord. 2012 Jan-Mar;26(1):17–27. de Brabander JM, Kramers RJ, Uylings HB. Layer-specific dendritic regression of pyramidal cells with ageing in the human prefrontal cortex. Eur J Neurosci. 1998 Apr;10(4):1261–9. Jacobs B, Driscoll L, Schall M. Life-span dendritic and spine changes in areas 10 and 18 of human cortex: a quantitative Golgi study. J Comp Neurol. 1997 Oct 6;386(4):661–80. Wallace M, Frankfurt M, Arellanos A, Inagaki T, Luine V. Impaired recognition memory and decreased prefrontal cortex spine density in aged female rats. Ann N Y Acad Sci. 2007 Feb;1097:54–7. Dickstein DL, Weaver CM, Luebke JI, Hof PR. Dendritic spine changes associated with normal aging. Neuroscience. 2013 Oct;251:21–32. Henley JM, Wilkinson KA. AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging. Dialogues Clin Neurosci. 2013 Mar;15(1):11–27. Morrison JH, Baxter MG. The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat Rev Neurosci. 2012 Mar;13(4):240–50. Costello E, Kafchinski M, Vrazel J, Sullivan P. Motivators, barriers, and beliefs regarding physical activity in an older adult population. J Geriatr Phys Ther. 2011 Jul-Sep;34(3):138–47. Yao R, Nishii K, Kito T, Teranishi T, Sugiyama T, Sakai K, et al. A novel device to prevent osteoporosis by promoting bone metabolism using a newly developed double-loading stimulation with vibration and shaking. Okajimas Folia Anat Jpn. 2019;96(1):13–21. Yamada K, Nishii K, Sakai K, Teranishi T. Stimulus in the form of rotation and shaking of a platform and its effect on the formation of trabecular bone in the lumbar vertebrae of mice. Aging Clin Exp Res. 2013 Dec;25(6):625–32. Yao R, Nishii K, Aizu N, Kito T, Sakai K, Yamada K. Maintaining aging hippocampal function with safe and feasible shaking exercise in SAMP10 mice. Dement Geriatr Cogn Disord. 2020;49(2):185–93. Yao R, Nishii K, Aizu N, Kito T, Sakai K, Yamada K. Maintenance of the amygdala-hippocampal circuit function with safe and feasible shaking exercise therapy in SAMP-10 mice. Dement Geriatr Cogn Dis Extra. 2021 May;11(2):114–21. Fattoretti P, Malatesta M, Cisterna B, Milanese C, Zancanaro C. Modulatory effect of aerobic physical activity on synaptic ultrastructure in the old mouse hippocampus. Front Aging Neurosci. 2018 May;10(10):141. Stepan J, Dine J, Eder M. Functional optical probing of the hippocampal trisynaptic circuit in vitro: network dynamics, filter properties, and polysynaptic induction of CA1 LTP. Front Neurosci. 2015 May;9:160. Lin JJ, Rugg MD, Das S, Stein J, Rizzuto DS, Kahana MJ, et al. Theta band power increases in the posterior hippocampus predict successful episodic memory encoding in humans. Hippocampus. 2017 Oct;27(10):1040–53. Clarke JR, Cammarota M, Gruart A, Izquierdo I, Delgado-García JM. Plastic modifications induced by object recognition memory processing. Proc Natl Acad Sci U S A. 2010 Feb;107(6):2652–7. Erion JR, Wosiski-Kuhn M, Dey A, Hao S, Davis CL, Pollock NK, et al. Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity. J Neurosci. 2014 Feb 12;34(7):2618–31. Article / Publication Details

First-Page Preview

Abstract of Research Article

Received: June 03, 2022
Accepted: August 07, 2022
Published online: December 14, 2022

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

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