Juvenile idiopathic arthritis polygenic risk scores are associated with cardiovascular phenotypes in early adulthood: a phenome-wide association study

Thierry S, Fautrel B, Lemelle I, Guillemin F. Prevalence and incidence of juvenile idiopathic arthritis: a systematic review. Joint Bone Spine. 2014;81(2):112–7. https://doi.org/10.1016/j.jbspin.2013.09.003.

Article  PubMed  Google Scholar 

Shoop-Worrall SJW, Kearsley-Fleet L, Thomson W, Verstappen SMM, Hyrich KL. How common is remission in juvenile idiopathic arthritis: a systematic review. Semin Arthritis Rheum. 2017;47(3):331–7. https://doi.org/10.1016/j.semarthrit.2017.05.007.

Article  PubMed  PubMed Central  Google Scholar 

Tsao CW, Vasan RS. Cohort profile: the Framingham Heart Study (FHS): overview of milestones in cardiovascular epidemiology. Int J Epidemiol. 2015;44(6):1800–13. https://doi.org/10.1093/ije/dyv337.

Article  PubMed  PubMed Central  Google Scholar 

Aday AW, Ridker PM. Targeting residual inflammatory risk: a shifting paradigm for atherosclerotic disease. Front Cardiovasc Med. 2019;6:16. https://doi.org/10.3389/fcvm.2019.00016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amaya-Amaya J, Montoya-Sanchez L, Rojas-Villarraga A. Cardiovascular involvement in autoimmune diseases. Biomed Res Int. 2014;2014:367359. https://doi.org/10.1155/2014/367359.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hippisley-Cox J, Coupland C, Brindle P. Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ. 2017;357:j2099. https://doi.org/10.1136/bmj.j2099.

Article  PubMed  PubMed Central  Google Scholar 

Agca R, Heslinga SC, Rollefstad S, Heslinga M, McInnes B, Peters MJL, et al. EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Ann Rheum Dis. 2017;76(1):17–28. https://doi.org/10.1136/annrheumdis-2016-209775.

Article  CAS  PubMed  Google Scholar 

Coulson E, Ng WF, Platt PN, Foster HE. Cardiovascular risk in adults with juvenile idiopathic arthritis. Arthritis Rheum. 2013;65:S120–1. https://doi.org/10.1002/art.38216.

Article  Google Scholar 

Anderson JH, Anderson KR, Aulie HA, Crowson CS, Mason TG, Ardoin SP, et al. Juvenile idiopathic arthritis and future risk for cardiovascular disease: a multicenter study. Scand J Rheumatol. 2016;45(4):299–303. https://doi.org/10.3109/03009742.2015.1126345.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hussain KS, Gulati R, Satheesh S, Negi VS. Early-onset subclinical cardiovascular damage assessed by non-invasive methods in children with Juvenile Idiopathic Arthritis: analytical cross-sectional study. Rheumatol Int. 2021;41(2):423–9. https://doi.org/10.1007/s00296-020-04689-z.

Article  CAS  PubMed  Google Scholar 

Breda L, Di Marzio D, Giannini C, Gaspari S, Nozzi M, Scarinci A, et al. Relationship between inflammatory markers, oxidant-antioxidant status and intima-media thickness in prepubertal children with juvenile idiopathic arthritis. Clin Res Cardiol. 2013;102(1):63–71.

Article  CAS  PubMed  Google Scholar 

Aranda-Valera IC, Arias I, de la Rosa R, Roldan-Molina M-A, Torres-Granados C, Patino-Trives A, et al. Subclinical cardiovascular risk signs in adults with juvenile idiopathic arthritis in sustained remission. Pediatr Rheumatol Online J. 2020;18(1):59. https://doi.org/10.1186/s12969-020-00448-3.

Article  PubMed  PubMed Central  Google Scholar 

Vlahos AP, Theocharis P, Bechlioulis A, Naka KK, Vakalis K, Papamichael ND, et al. Changes in vascular function and structure in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2011;63(12):1736–44. https://doi.org/10.1002/acr.20613.

Article  Google Scholar 

Lewis CM, Vassos E. Polygenic risk scores: from research tools to clinical instruments. Genome Med. 2020;12(1):44. https://doi.org/10.1186/s13073-020-00742-5.

Article  PubMed  PubMed Central  Google Scholar 

Clarke SLN, Richmond RC, Zheng J, Spiller W, Ramanan AV, Sharp GC, et al. Examining health outcomes in juvenile idiopathic arthritis: a genetic epidemiology study. ACR Open Rheumatol. 2022. https://doi.org/10.1002/acr2.11404.

Article  PubMed  PubMed Central  Google Scholar 

Boyd A, Golding J, Macleod J, Lawlor DA, Fraser A, Henderson J, et al. Cohort profile: the ’children of the 90s’–the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol. 2013;42(1):111–27. https://doi.org/10.1093/ije/dys064.

Article  PubMed  Google Scholar 

Fraser A, Macdonald-Wallis C, Tilling K, Boyd A, Golding J, Davey Smith G, et al. Cohort profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. Int J Epidemiol. 2013;42(1):97–110. https://doi.org/10.1093/ije/dys066.

Article  PubMed  Google Scholar 

Northstone K, Lewcock M, Groom A, Boyd A, Macleod J, Timpson N, et al. The Avon Longitudinal Study of Parents and Children (ALSPAC): an update on the enrolled sample of index children in 2019. Wellcome Open Res. 2019;4:51. https://doi.org/10.12688/wellcomeopenres.15132.1.

Article  PubMed  PubMed Central  Google Scholar 

Avon Longitundinal Study of Parents and Children. Web site: http://www.bristol.ac.uk/alspac/researchers/our-data/. Accessed 26 Oct 26 2021.

Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81. https://doi.org/10.1016/j.jbi.2008.08.010.

Article  PubMed  Google Scholar 

Taylor AE, Jones HJ, Sallis H, Euesden J, Stergiakouli E, Davies NM, et al. Exploring the association of genetic factors with participation in the Avon Longitudinal Study of Parents and Children. Int J Epidemiol. 2018;47(4):1207–16. https://doi.org/10.1093/ije/dyy060.

Article  PubMed  PubMed Central  Google Scholar 

Lopez-Isac E, Smith SL, Marion MC, Wood A, Sudman M, Yarwood A, et al. Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms. Ann Rheum Dis. 2020. https://doi.org/10.1136/annrheumdis-2020-218481.

Article  PubMed  Google Scholar 

 Choi SW, O'Reilly PF. PRSice-2: polygenic risk score software for biobank-scale data. Gigascience. 2019;8(7). https://doi.org/10.1093/gigascience/giz082

Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr. 2008;21(2):93–111; quiz 89-90. https://doi.org/10.1016/j.echo.2007.11.011.

Article  PubMed  Google Scholar 

Marwick TH, Gillebert TC, Aurigemma G, Chirinos J, Derumeaux G, Galderisi M, et al. Recommendations on the use of echocardiography in adult hypertension: a report from the European Association of Cardiovascular Imaging (EACVI) and the American Society of Echocardiography (ASE)dagger. Eur Heart J Cardiovasc Imaging. 2015;16(6):577–605. https://doi.org/10.1093/ehjci/jev076.

Article  PubMed  Google Scholar 

Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322(22):1561–6. https://doi.org/10.1056/NEJM199005313222203.

Article  CAS  PubMed  Google Scholar 

Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH. Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med. 1991;114(5):345–52. https://doi.org/10.7326/0003-4819-114-5-345.

Article  CAS  PubMed  Google Scholar 

Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18(12):1440–63. https://doi.org/10.1016/j.echo.2005.10.005.

Article  PubMed  Google Scholar 

Author. R: A language and environment for statistical computing. Journal. 2020 Available from: https://www.R-project.org/.

Author. RStudio: Integrated Development Environment for R. Journal. 2020 Available from: http://www.rstudio.com/.

Nurnberger J, Dammer S, Opazo Saez A, Philipp T, Schafers RF. Diastolic blood pressure is an important determinant of augmentation index and pulse wave velocity in young, healthy males. J Hum Hypertens. 2003;17(3):153–8. https://doi.org/10.1038/sj.jhh.1001526.

Article  CAS  PubMed  Google Scholar 

Nagano M, Nakamura M, Sato K, Tanaka F, Segawa T, Hiramori K. Association between serum C-reactive protein levels and pulse wave velocity: a population-based cross-sectional study in a general population. Atherosclerosis. 2005;180(1):189–95. https://doi.org/10.1016/j.atherosclerosis.2004.11.019.

Article  CAS  PubMed  Google Scholar 

Canovas R, Cobb J, Brozynska M, Bowes J, Li YR, Smith SL, et al. Genomic risk scores for juvenile idiopathic arthritis and its subtypes. Ann Rheum Dis. 2020;79(12):1572–9. https://doi.org/10.1136/annrheumdis-2020-217421.

Article  PubMed  Google Scholar 

Hersh AO, von Scheven E, Yazdany J, Panopalis P, Trupin L, Julian L, et al. Differences in long-term disease activity and treatment of adult patients with childhood- and adult-onset systemic lupus erythematosus. Arthritis Rheum. 2009;61(1):13–20. https://doi.org/10.1002/art.24091.

Article  PubMed  PubMed Central  Google Scholar 

Schanberg LE, Sandborg C, Barnhart HX, Ardoin SP, Yow E, Evans GW, et al. Use of atorvastatin in systemic lupus erythematosus in children and adolescents. Arthritis Rheum. 2012;64(1):285–96. https://doi.org/10.1002/art.30645.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ardoin SP, Schanberg LE, Sandborg CI, Barnhart HX, Evans GW, Yow E, et al. Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein. Ann Rheum Dis. 2014;73(3):557–66. https://doi.org/10.1136/annrheumdis-2012-202315.

Article  CAS  PubMed  Google Scholar 

Chiesa ST, Charakida M, Georgiopoulos G, Dangardt F, Wade KH, Rapala A, et al. Determinants of intima-media thickness in the young: the ALSPAC study. JACC Cardiovasc Imaging. 2021;14(2):468–78. https://doi.org/10.1016/j.jcmg.2019.08.026.

Article  PubMed  PubMed Central 

留言 (0)

沒有登入
gif