Almeida JRM, Modig T, Petersson A, Hahn-Hagerdal B, Liden G, Gorwa-Grauslund MF (2007) Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae. J Chem Technol Biot 82(4):340–349

CAS  Google Scholar 

Alonso S, Rendueles M, Diaz M (2015) Microbial production of specialty organic acids from renewable and waste materials. Crit Rev Biotechnol 35(4):497–513

PubMed  Google Scholar 

Anastassiadis S, Aivasidis A, Wandrey C (2002) Citric acid production by Candida strains under intracellular nitrogen limitation. Appl Microbiol Biotechnol 60(1–2):81–87

CAS  PubMed  Google Scholar 

Angerer B, Holler E (1995) Large complexes of beta-poly(L-malate) with DNA polymerase alpha, histones, and other proteins in nuclei of growing plasmodia of Physarum polycephalum. BCHM 34(45):14741–14751

CAS  Google Scholar 

Battat E, Peleg Y, Bercovitz A, Rokem JS, Goldberg I (1991) Optimization of L-malic acid production by Aspergillus flavus in a stirred fermentor. Biotechnol Bioeng 37(11):1108–1116

CAS  PubMed  Google Scholar 

Becker J, Wittmann C (2015) Advanced biotechnology: metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products. Angew Chem Int Ed 54(11):3328–3350

CAS  Google Scholar 

Brown SH, Bashkirova L, Berka R, Chandler T, Doty T, McCall K, McCulloch M, McFarland S, Thompson S, Yaver D, Berry A (2013) Metabolic engineering of Aspergillus oryzae NRRL 3488 for increased production of L-malic acid. Appl Microbiol Biotechnol 97(20):8903–8912

CAS  PubMed  Google Scholar 

Cao W, Yan L, Li M, Liu X, Xu Y, Xie Z, Liu H (2020a) Identification and engineering a C4-dicarboxylate transporter for improvement of malic acid production in Aspergillus niger. Appl Microbiol Biotechnol 104(22):9773–9783

CAS  PubMed  Google Scholar 

Cao WF, Cao WL, Shen F, Luo JQ, Yin JX, Qiao CS, Wan YH (2020b) A sustainable pH shift control strategy for efficient production of beta-poly(L-malic acid) with CaCO3 addition by Aureobasidium pullulans ipe-1. Appl Microbiol Biotechnol 104(20):8691–8703

CAS  PubMed  Google Scholar 

Chen X, Xu G, Xu N, Zou W, Zhu P, Liu L, Chen J (2013) Metabolic engineering of Torulopsis glabrata for malate production. Metab Eng 19:10–16

CAS  PubMed  Google Scholar 

Chen X, Wang Y, Dong X, Hu G, Liu L (2017) Engineering rTCA pathway and C4-dicarboxylate transporter for L-malic acid production. Appl Microbiol Biotechnol 101(10):4041–4052

CAS  PubMed  Google Scholar 

Chen X, Zhou J, Ding Q, Luo Q, Liu L (2019) Morphology engineering of Aspergillus oryzae for l-malate production. Biotechnol Bioeng 116(10):2662–2673

CAS  PubMed  Google Scholar 

Cheng C, Zhou Y, Lin M, Wei P, Yang S-T (2017) Polymalic acid fermentation by Aureobasidium pullulans for malic acid production from soybean hull and soy molasses: fermentation kinetics and economic analysis. Bioresource Technol 223:166–174

CAS  Google Scholar 

Chi Z, Liu G-L, Liu C-G, Chi Z-M (2016a) Poly(beta-L-malic acid) (PMLA) from Aureobasidium spp and its current proceedings. Appl Microbiol Biotechnol 100(9):3841–3851

CAS  PubMed  Google Scholar 

Chi Z, Wang Z-P, Wang G-Y, Khan I, Chi Z-M (2016b) Microbial biosynthesis and secretion of l-malic acid and its applications. Crit Rev Biotechnol 36(1):99–107

CAS  PubMed  Google Scholar 

Choi S, Song CW, Shin JH, Lee SY (2015) Biorefineries for the production of top building block chemicals and their derivatives. Metab Eng 28:223–239

CAS  PubMed  Google Scholar 

Dai Z, Zhou H, Zhang S, Gu H, Yang Q, Zhang W, Dong W, Ma J, Fang Y, Jiang M, Xin F (2018) Current advance in biological production of malic acid using wild type and metabolic engineered strains. Bioresource Technol 258:345–353

CAS  Google Scholar 

Deng Y, Fong SS (2011) Laboratory evolution and multi-platform genome re-sequencing of the cellulolytic actinobacterium Thermobifida fusca. J Biol Chem 286(46):39958–39966

CAS  PubMed  PubMed Central  Google Scholar 

Deng Y, Mao Y, Zhang XJ (2016) Metabolic engineering of a laboratory-evolved Thermobifida fusca muC strain for malic acid production on cellulose and minimal treated lignocellulosic biomass. Biotechnol Prog 32(1):14–20

CAS  PubMed  Google Scholar 

Ding Q, Luo Q, Zhou J, Chen X, Liu L (2018) Enhancing l-malate production of Aspergillus oryzae FMME218-37 by improving inorganic nitrogen utilization. Appl Microbiol Biotechnol 102(20):8739–8751

CAS  PubMed  Google Scholar 

Dong X, Chen X, Qian Y, Wang Y, Wang L, Qiao W, Liu L (2017) Metabolic engineering of Escherichia coli W3110 to produce L-malate. Biotechnol Bioeng 114(3):656–664

PubMed  Google Scholar 

Dong J, Du YM, Zhou YP, Yang ST (2014) Butanol production from soybean hull and soy molasses by acetone-butanol-ethanol fermentation, in: Brentin, R.P. (Ed.) Soy-Based Chem Mater 1178, 25–41

Dueber JE, Wu GC, Malmirchegini GR, Moon TS, Petzold CJ, Ullal AV, Prather KLJ, Keasling JD (2009) Synthetic protein scaffolds provide modular control over metabolic flux. Nat Biotechnol 27(8):753-U107

CAS  PubMed  Google Scholar 

Engel CAR, Straathof AJJ, Zijlmans TW, van Gulik WM, van der Wielen LAM (2008) Fumaric acid production by fermentation. Appl Microbiol Biotechnol 78(3):379–389

Google Scholar 

Feng J, Yang J, Yang W, Chen J, Jiang M, Zou X (2018) Metabolome- and genome-scale model analyses for engineering of Aureobasidium pullulans to enhance polymalic acid and malic acid production from sugarcane molasses. Biotechnol Biofuels 11(1):94. https://doi.org/10.1186/s13068-018-1099-7

Ferreira JA, Lennartsson PR, Taherzadeh MJ (2015) Production of ethanol and biomass from thin stillage by Neurospora intermedia: a pilot study for process diversification. Eng Life Sci 15(8):751–759

CAS  Google Scholar 

Gadagi R, Shin W, Sa T (2007) Malic acid mediated aluminum phosphate solubilization by Penicillium oxalicum CBPS-3F-Tsa isolated from Korean paddy rhizosphere soil. First Int Meeting Microbial Phosphate Solubilization 102:285–290

Google Scholar 

Glenn JM, Gray M, Wethington LN, Stone MS, Stewart RW Jr, Moyen NE (2017) Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females. Eur J Nutr 56(2):775–784

CAS  PubMed  Google Scholar 

Goldberg I, Rokem JS, Pines O (2006) Organic acids: old metabolites, new themes. J Che Technol Biot 81(10):1601–1611

CAS  Google Scholar 

Iyyappan J, Baskar G, Bharathiraja B, Saravanathamizhan R (2018a) Malic acid production from biodiesel derived crude glycerol using morphologically controlled Aspergillus niger in batch fermentation. Bioresource Technol 269:393–399

CAS  Google Scholar 

Iyyappan J, Bharathiraja B, Baskar G, Jayamuthunagai J, Barathkumar S, Shiny RA (2018b) Malic acid production by chemically induced Aspergillus niger MTCC 281 mutant from crude glycerol. Bioresource Technol 251:264–267

CAS  Google Scholar 

Iyyappan J, Baskar G, Gnansounou E, Pandey A, Raaman JK, Bharathiraja B, Praveenkumar R (2019) Recent advances in microbial production of malic acid from renewable byproducts. Rev Environ Sci Bio 18(3):579–595

CAS  Google Scholar 

Iyyappan J, Baskar G, Bharathiraja B, Gopinath M (2020) Enhanced malic acid production using Aspergillus niger coupled with in situ product recovery. Bioresour Technol 308:123259. https://doi.org/10.1016/j.biortech.2020.123259

Jantama K, Zhang X, Moore JC, Shanmugam KT, Svoronos SA, Ingram LO (2008) Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli C. Biotechnol Bioeng 101(5):881–893

CAS  PubMed  Google Scholar 

Ji XJ, Huang H, Ouyang PK (2011) Microbial 2,3-butanediol production: a state-of-the-art review. Biotechnol Adv 29(3):351–364

CAS  PubMed  Google Scholar 

Ji LH, Wang J, Luo QL, Ding Q, Tang WX, Chen XL, Liu LM (2021) Enhancing L-malate production of Aspergillus oryzae by nitrogen regulation strategy. Appl Microbiol Biotechnol 105(8):3101–3113

CAS  PubMed  Google Scholar 

Jönsson LJ, Alriksson B, Nilvebrant NO (2013) Bioconversion of lignocellulose: inhibitors and detoxification. Biotechnol Biofuels 6:16. https://doi.org/10.1186/1754-6834-6-16

Kim HO, Lum C, Lee MS (1997) Malic acid: a convenient precursor for the synthesis of peptide secondary structure mimetics. Tetrahedron Lett 38(28):4935–4938

CAS  Google Scholar 

Klinke HB, Thomsen AB, Ahring BK (2004) Inhibition of ethanol-producing yeast and bacteria by degradation products produced during pre-treatment of biomass. Appl Microbiol Biotechnol 66(1):10–26

CAS  PubMed  Google Scholar 

Knuf C, Nookaew I, Brown SH, McCulloch M, Berry A, Nielsen J (2013) Investigation of malic acid production in Aspergillus oryzae under nitrogen starvation conditions. Appl Environ Microbiol 79(19):6050–6058

CAS  PubMed  PubMed Central  Google Scholar 

Knuf C, Nookaew I, Remmers I, Khoomrung S, Brown S, Berry A, Nielsen J (2014) Physiological characterization of the high malic acid-producing Aspergillus oryzae strain 2103a–68. Appl Microbiol Biotechnol 98(8):3517–3527

CAS  PubMed  Google Scholar 

Koevilein A, Kubisch C, Cai L, Ochsenreither K (2020) Malic acid production from renewables: a review. J Chem Technol Biot 95(3):513–526

CAS  Google Scholar 

Kubisch C, Ochsenreither K (2022) Valorization of a pyrolytic aqueous condensate and its main components for L-malic acid production with Aspergillus oryzae DSM 1863. Fermentation-Basel 8(3):107. https://doi.org/10.3390/fermentation8030107

Kurgan G, Kurgan L, Schneider A, Onyeabor M, Rodriguez-Sanchez Y, Taylor E, Martinez R, Carbonell P, Shi X, Gu H, Wang X (2019) Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search. Appl Microbiol Biotechnol 103(21–22):9001–9011

CAS  PubMed  Google Scholar 

Kuypers MMM, Marchant HK, Kartal B (2018) The microbial nitrogen-cycling network. Nat Rev Microbiol 16(5):263–276

CAS  PubMed  Google Scholar 

Leathers TD, Manitchotpisit P (2013) Production of poly(beta-L-malic acid) (PMA) from agricultural biomass substrates by Aureobasidium pullulans. Biotechnol Lett 35(1):83–89

CAS  PubMed  Google Scholar 

Li X, Liu Y, Yang Y, Zhang H, Wang H, Wu Y, Zhang M, Sun T, Cheng J, Wu X, Pan L, Jiang S, Wu H (2014) High levels of malic acid production by the bioconversion of corn straw hydrolyte using an isolated Rhizopus delemar strain. Biotechnol Bioproc E 19(3):478–492

CAS  Google Scholar 

Li Z-J, Hong P-H, Da Y-Y, Li L-K, Stephanopoulos G (2018) Metabolic engineering of Escherichia coli for the production of L-malate from xylose. Metab Eng 48:25–32

CAS  PubMed  Google Scholar 

Li J, Chen B, Gu S, Zhao Z, Liu Q, Sun T, Zhang Y, Wu T, Liu D, Sun W, Tian C (2021) Coordination of consolidated bioprocessing technology and carbon dioxide fixation to produce malic acid directly from plant biomass in Myceliophthora thermophila. Biotechnol Biofuels 14(1):186

CAS  PubMed