A new pilot investigation demonstrates the use of dynamic contrast-enhanced (DCE) MRI for characterization of blood–brain barrier (BBB) dysfunction resulting from traumatic brain injury (TBI). DCE MRI in 40 adults with TBI revealed a higher mean volume transfer constant and normalized permeability index value, compared with healthy controls, indicative of BBB disruption in the TBI group. As expected, focal lesions were associated with the greatest BBB disruption, followed by perilesional and nonlesional regions, which showed subtle but still significant elevation of the mean volume transfer constant compared with controls.