N.I.W. is an advisor and/or co-investigator for trials in metachromatic leukodystrophy, adult-onset leukodystrophy with spheroids and pigmented glia and other leukodystrophies (Shire/Takeda, Orchard, Ionis, PassageBio, VigilNeuro), without personal payment. M.S.v.d.K. is a consultant for Calico regarding trials in vanishing white matter and co-investigator for Ionis regarding a trial in Alexander disease, without personal payment. She is named on patent P112686US00 “Therapeutic effects of guanabenz treatment in vanishing white matter” and on pending patent P112686CA00 “The use of guanabenz in the treatment of VWM”, both for the VU University Medical Center, Amsterdam, Netherlands. Y.A.L.P. declares no competing interests.