Cyclooxygenase-2 is a critical determinant of angiotensin II-induced vascular remodeling and stiffness in resistance arteries of ouabain-treated rats

aDepartment of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo

bDepartment of Physiology and Pharmacology, Biosciences Center, Federal University of Pernambuco, Recife, Brazil

Correspondence to Luciana Venturini Rossoni, MD, PhD, Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, Prof. Lineu Prestes Av, Rm 225, 1524, 05508-000 São Paulo, SP, Brazil. Tel: +55 11 3091 8038; e-mail: [email protected]

Abbreviations: ε, circumferential strain; σ, circumferential wall stress; CA, collagen area; CSA, cross-sectional area; HH, hydralazine hydrochloride plus hydrochlorothiazide; KHS, Krebs–Henseleit solution; LA, luminal area; LOS, losartan; MRA, mesenteric resistance arteries; NIM, nimesulide; OUA, ouabain-treated group; TC, percentage of the total collagen; VEH, vehicle group; WA, total wall area; WT, wall thickness

Received 28 March, 2022

Revised 11 June, 2022

Accepted 13 June, 2022

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com).

留言 (0)

沒有登入
gif