Integrin subunit α -v (ITGAV) has been demonstrated to be dysregulated and involved in cancer promotion processes in a variety of cancers, but studies on nasopharyngeal carcinoma (NPC) have been limited. Our study aimed to comprehensively assess the expression level and potential mechanisms of ITGAV in NPC.
ResultsA total of 13 mRNA expression datasets and internal tissue microarrays were included. ITGAV protein and mRNA were overexpressed in NPC. The pathways of upregulated genes positively related to ITGAV in NPC were analyzed, and the PI3K−Akt signaling pathway, cell cycle, and human papillomavirus infections were most significantly enriched. The protein–protein interaction network was constructed for the genes enriched in these pathways, and the corresponding hub genes were obtained. Among them, breast cancer susceptibility gene 1 (BRCA1) was predicted to be a transcription factor of ITGAV via the Cistrome DB Toolkit, which was also confirmed by ChIP-seq information and correlation calculations.
ConclusionsITGAV is overexpressed in NPC and can regulate BRCA1 to participate in the cancer process. ITGAV serves as a potential therapeutic target in NPC patients.
How to cite: Huang S-W, Luo J-Y, Qin L-T, et al. Upregulation of ITGAV and the underlying mechanisms in nasopharyngeal carcinoma. Electron J Biotechnol 2022;60. https://doi.org/10.1016/j.ejbt.2022.09.002.
KeywordsBRCA1
Breast cancer
Cancer
Cell cycle
Gene chip
Integrin
ITGAV
Nasopharyngeal carcinoma immunohistochemistry
Therapeutic target
Transcription factors
AbbreviationsBRCA1Breast cancer susceptibility gene 1
DEGsDifferentially expressed genes
GEOGene Expression Omnibus
IRSImmunoreactivity score
ITGAVIntegrin subunit α-V
KEGGKyoto Encyclopedia of Genes and Genomes
NPCNasopharyngeal carcinoma
NCBINational Center for Biotechnology Information
PPIProtein-protein interaction
ROCReceiver operating characteristic
SMDStandard mean deviation
SROCSummary receiver operating characteristic
TCGAThe Cancer Genome Atlas
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