Keywords
PLGA-PEG
Ocular topical delivery
Mucoadhesion
Controlled release
In vivo ocular tolerability
AbbreviationsRGCs
Retinal Ganglion Cells
LPHNs
Lipid-Polymer Hybrid Nanoparticles
mel-LPHNs
melatonin-loaded lipid-polymer hybrid nanoparticles
RPE
Retinal Pigment Epithelium
PLGA
Polylactic-co-glycolic acid
DOPE
1,2-dioleoyl-sn-glycero-3-phosphoethanolamin
DOTAP
1,2-dioleoyl-3-trimethylammonium-propane
DOPC
1,2-dioleoyl-sn-glycero-3-phosphocholine
DSPE-PEG
1,2-distearoyl-sn-glycero-3-phosphoethanolamine–polyethylene glycol
RES
reticuloendothelial system
HREC
Human Retinal Endothelial Cells
CTAB
Cetyltrimethylammonium Bromide
DDAB
Didodecyldimethylammonium Bromide
%EE
Encapsulation Efficiency
ANOVA
Analysis of Variance
PCS
Photon Correlation Spectroscopy
TEM
Transmission Electron Microscope
PBS
Phosphate Buffered Saline
HPLC
High-Performance Liquid Chromatography
DSC
Differential Scanning Calorimetry
FTIR
Fourier-Transform Infrared Spectroscopy
ATR
Attenuated Total Reflectance
DCFH-DA
Dichloro-dihydro-fluorescein Diacetate
DCFDA
2′,7′-dichlorodihydrofluorescein diacetate
ICH
International Conference on Harmonization
ARVO
Association for Research in Vision and Ophthalmology
2FI
Two Factor Interaction
ROS
Reactive Oxygen Species
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