Glycyrrhizin and boswellic acids, the golden nutraceuticals: multitargeting for treatment of mild–moderate COVID-19 and prevention of post-COVID cognitive impairment

Abdel-Tawab M (2021) Considerations to be taken when carrying out medicinal plant research—what we learn from an insight into the IC50 values, bioavailability and clinical efficacy of exemplary anti-inflammatory herbal components. Pharmaceuticals 14:437. https://doi.org/10.3390/ph14050437

CAS  Article  PubMed  PubMed Central  Google Scholar 

Ahmad S, Waheed Y, Abro A, Abbasi SW, Ismail S (2021) Molecular screening of glycyrrhizin-based inhibitors against ACE2 host receptor of SARS-CoV-2. J Mol Model 27(7):206. https://doi.org/10.1007/s00894-021-04816-y

CAS  Article  PubMed  PubMed Central  Google Scholar 

Aldahlawi AM, Alzahrani AT, Elshal MF (2020) Evaluation of immunomodulatory effects of Boswellia sacra essential oil on T-cells and dendritic cells. BMC Complement Med Ther 20:352. https://doi.org/10.1186/s12906-020-03146-5

CAS  Article  PubMed  PubMed Central  Google Scholar 

Al-Kuraishy HM, Al-Gareeb AI, Alkazmi L, Habotta OA, Batiha GE (2022) High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons. Inflammopharmacology 30(3):811–820. https://doi.org/10.1007/s10787-022-00988-y

CAS  Article  PubMed  PubMed Central  Google Scholar 

Alshanqeeti S, Bhargava A (2022) COVID-19 rebound after paxlovid treatment: a case series and review of literature. Cureus 14(6):e26239. https://doi.org/10.7759/cureus.26239

Article  PubMed  PubMed Central  Google Scholar 

Baker HA, Safavynia SA, Evered LA (2021) The “third wave”: impending cognitive and functional decline in COVID-19 survivors. Br J Anaesth 1:44–47. https://doi.org/10.1016/j.bja.2020.09.045

CAS  Article  Google Scholar 

Baram SM, Karima S, Shateri S et al (2019) Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids: a randomized, double- blind, placebo-controlled, pilot trial. Inflammopharmacology 27:1101–1112. https://doi.org/10.1007/s10787-019-00627

CAS  Article  PubMed  Google Scholar 

Barzin Tond S, Balenci L, Khajavirad N, Salehi M, Tafakhori A, Shahmohammadi MR et al (2022) Inflawell® improves neutrophil-to-lymphocyte ratio and shortens hospitalization in patients with moderate COVID-19, in a randomized double-blind placebo-controlled clinical trial. Inflammopharmacology 30(2):465–475. https://doi.org/10.1007/s10787-022-00928-w

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bernal AJ, Gomes da Silva MM, Musungaie DB, Kovalchuk E, Gonzalez A et al (2022) Molnupiravir for oral treatment of Covid-19 in Nonhospitalized patients. N Engl J Med 386(6):509–520. https://doi.org/10.1056/NEJMoa2116044

CAS  Article  Google Scholar 

Bocci G, Bradfute S, Ye C, Garcia M, Parvathareddy J, Reichard W et al (2020) Virtual and in vitro antiviral screening revive therapeutic drugs for COVID-19. ACS Pharmacol Transl Sci 3(6):1278–1292. https://doi.org/10.1021/acsptsci.0c00131

CAS  Article  PubMed  PubMed Central  Google Scholar 

Borooni S, Nourbakhsh F, Tajbakhsh E, Behshood P (2020) The effects of aqueous extract of boswellia serrata on memory impairment induced by lipopolysaccharide. IJML 7(4):300–311

CAS  Google Scholar 

Buccellato FR, D’Anca M, Fenoglio C, Scarpini E, Galimberti D (2021) Role of oxidative damage in Alzheimer’s disease and neurodegeneration: from pathogenic mechanisms to biomarker discovery. Antioxidants (Basel) 10(9):1353. https://doi.org/10.3390/antiox10091353

CAS  Article  Google Scholar 

Caliebe RH, Scior T, Ammon HPT (2021) Binding of boswellic acids to functional proteins of the SARS-CoV-2 virus: bioinformatic studies. Arch Pharm (weinheim) 354(11):e2100160. https://doi.org/10.1002/ardp.202100160

CAS  Article  Google Scholar 

Ceban F, Ling S, Lui LMW, Lee Y, Gill H, Teopiz KM et al (2022) Fatigue and cognitive impairment in Post-COVID-19 Syndrome: a systematic review and meta-analysis. Brain Behav Immun 101:93–135. https://doi.org/10.1016/j.bbi.2021.12.020

CAS  Article  PubMed  Google Scholar 

Chavda VP, Patel AB, Vihol D, Vaghasiya D, Ahmed K, Trivedi K, Dave D (2022) Herbal remedies, nutraceuticals, and dietary supplements for covid-19 management: an update. Clin Complem Med Pharmacol 2(1):100021. https://doi.org/10.1016/j.ccmp.2022.100021

Article  Google Scholar 

Chen R, Huang Y, Quan J, Liu J, Wang H, Billiar TR, Zeh Lotze MT., HJ, Kang R, Tang D, (2020) HMGB1 as a potential biomarker and therapeutic target for severe COVID-19. Heliyon 6(12):e05672. https://doi.org/10.1016/j.heliyon.2020.e05672

Article  PubMed  PubMed Central  Google Scholar 

Cho MJ, Kim JH, Park CH, Lee AY, Shin YS, Lee JH, Park CG, Cho EJ (2018) Comparison of the effect of three licorice varieties on cognitive improvement via an amelioration of neuroinflammation in lipopolysaccharide-induced mice. Nutr Res Pract 12(3):191–198. https://doi.org/10.4162/nrp.2018.12.3.191

CAS  Article  PubMed  PubMed Central  Google Scholar 

Coronavirus (COVID-19) Update: FDA Authorizes First Oral Antiviral for Treatment of COVID-19, December 22, 2021, https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-oral-antiviral-treatment-covid-19

Crivelli L, Palmer K, Calandri I, Guekht A, Beghi E, Carroll W et al (2022) Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis. Alzheimers Dement 18(5):1047–1066. https://doi.org/10.1002/alz.12644

CAS  Article  PubMed  PubMed Central  Google Scholar 

Elsersy HE, Zahran MAH, Elbakry A-E, Abd-Elwahab M, Ahmed MM, Elgandy MS, Mohammed M, Elewa NM (2022) Combined nasal, oropharyngeal povidone iodine plus glycyrrhizic acid sprays, accelerate clinical and laboratory recovery and reduces household transmission of SARS-CoV-2: a randomized placebo-controlled clinical trial. Front Med 9:863917. https://doi.org/10.3389/fmed.2022.863917

Article  Google Scholar 

Fatima SW, Alam S, Khare SK (2022) Molecular and structural insights of β-boswellic acid and glycyrrhizic acid as potent SARS-CoV-2 Envelope protein inhibitors. Phytomed Plus. 2(2):100241. https://doi.org/10.1016/j.phyplu.2022.100241

Article  PubMed  PubMed Central  Google Scholar 

Fomenko VV, Rudometova NB, Yarovaya OI, Rogachev AD, Fando AA et al (2022) Synthesis and in vitro study of antiviral activity of glycyrrhizin nicotinate derivatives against HIV-1 pseudoviruses and SARS-CoV-2 viruses. Molecules 27:295. https://doi.org/10.3390/molecules27010295

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gomaa AA, Abdel-Wadood YA (2021) The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions. Phytomed plus 1(3):100043. https://doi.org/10.1016/j.phyplu.2021.100043

Article  PubMed  Google Scholar 

Gomaa AA, Farghaly HA, Abdel-Wadood YA, Gomaa GA (2021a) Potential therapeutic effects of boswellic acids/Boswellia serrata extract in the prevention and therapy of type 2 diabetes and Alzheimer’s disease. Naunyn Schmiedebergs Arch Pharmacol 394(11):2167–2185. https://doi.org/10.1007/s00210-021-02154-7

CAS  Article  PubMed  Google Scholar 

Gomaa AA, Makboul RM, Al-Mokhtar MA, Nicola MA (2019) Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance of diabetic rats through inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines. Biomed Pharmacother 109:281–292. https://doi.org/10.1016/j.biopha.2018.10.056

CAS  Article  PubMed  Google Scholar 

Gomaa AA, Mohamed HS, Abd-Ellatief RB, Gomaa MA, Hammam DS (2022) Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial. Inflammopharmacology. 30(2):477–486. https://doi.org/10.1007/s10787-022-00939-7

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gomaa AA, Mohamed HS, Abd-Ellatief RB, Gomaa MA (2021) Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly. Inflammopharmacology 29(4):1033–1048. https://doi.org/10.1007/s10787-021-00841-8

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gong Y, Jiang X, Yang S, Huang Y, Hong J, Ma Y, Fang X, Fang Y, Wu J (2022) The Biological Activity of 3-O-Acetyl-11-keto-β-Boswellic Acid in Nervous System Diseases. Neuromolecular Med 18:1–11. https://doi.org/10.1007/s12017-022-08707-0

CAS  Article  Google Scholar 

Gottlieb RL, Vaca CE, Paredes J, Mera J, Webb BJ, Perez G et al (2021) Early remdesivir to prevent progression to severe Covid-19 in outpatients. N Engl J Med 386(4):305–315. https://doi.org/10.1056/NEJMoa2116846

Article  PubMed  Google Scholar 

.Gowda P, Patrick S, Joshi SD, Kumawat RK, Sen E (2021) Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication. Cytokine 142:155496. https://doi.org/10.1016/j.cyto.2021.155496

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gu J, Ran X, Deng J, Zhang A, Peng G, Du J, Wen D, Jiang B, Xia F (2022) Glycyrrhizin alleviates sepsis-induced acute respiratory distress syndrome via suppressing of HMGB1/TLR9 pathways and neutrophils extracellular traps formation. Int Immunopharmacol 108:108730. https://doi.org/10.1016/j.intimp.2022.108730

CAS  Article  PubMed  Google Scholar 

Gunasekaran V, Avarachan J, Augustine A, Khayum A (2021) 3-O-Acetyl-11-keto-β-boswellic acid ameliorates acquired, consolidated and recognitive memory deficits through the regulation of hippocampal PPAR γ, MMP9 and MMP2 genes in dementia model. Heliyon 7(12):e08523. https://doi.org/10.1016/j.heliyon.2021.e08523

CAS  Article  PubMed  PubMed Central  Google Scholar 

Haage V, De Jager PL (2022) Neuroimmune contributions to Alzheimer’s disease: a focus on human data. Mol Psychiatry 6:1–18. https://doi.org/10.1038/s41380-022-01637-0

Article  Google Scholar 

Hadad R, Khoury J, Stanger C, Fisher T, Schneer S, Ben-Hayun R, Possin K et al (2022) Cognitive dysfunction following COVID-19 infection. J Neurovirol 26:1–8. https://doi.org/10.1007/s13365-022-01079-y

CAS  Article  Google Scholar 

Haghaei H, Soltani S (2021) Aref hosseini S, Rashidi M, Karima S Boswellic Acids as Promising leads in drug development against Alzheimer’s Disease. Pharm Sci 27(1):14–31. https://doi.org/10.34172/PS.2020.25

CAS  Article  Google Scholar 

Hammond J, Leister-Tebbe H, Gardener A et al (2022) Oral nirmatrelvir for high-risk, nonhospitalized adults with Covid-19. N Engl J Med. https://doi.org/10.1056/NEJMoa2118542

留言 (0)

沒有登入
gif