Abdulbasit A, Michael FS, Onaopemipo AS, Abdulmusawwir A-O, Aminu I, Tobechukwu AN, Imam AW, Aremu AO, Folajimi O, Aderonke ABJP (2018) Glucocorticoid receptor activation selectively influence performance of Wistar rats in Y-maze. Pathophysiology 25:41–50

Article  CAS  PubMed  Google Scholar 

Abomosallam M, Hendam BM, Abdallah AA, Refaat R, Elshatory A, Gad El Hak HN (2023) Neuroprotective effect of piracetam-loaded magnetic chitosan nanoparticles against thiacloprid-induced neurotoxicity in albino rats. Inflammopharmacology 31:943–965

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adedara IA, Owoeye O, Awogbindin IO, Ajayi BO, Rocha JB, Farombi EOJC (2018) Diphenyl diselenide abrogates brain oxidative injury and neurobehavioural deficits associated with pesticide chlorpyrifos exposure in rats. Chemico-Biol Interact 296:105–116

Article  CAS  Google Scholar 

Aebi H, Mörikofer-Zwez S, von Wartburg J-P (1972) Alternative molecular forms of erythrocyte catalase, Structure and Function of Oxidation-Reduction Enzymes. Elsevier

Google Scholar 

Afolabi OK, Aderibigbe FA, Folarin DT, Arinola A, Wusu AD (2019) Oxidative stress and inflammation following sub-lethal oral exposure of cypermethrin in rats: mitigating potential of epicatechin. Heliyon 5:e02274

Article  PubMed  PubMed Central  Google Scholar 

Akbar S, Subhan F, Shahid M, Wadood A, Shahbaz N, Farooq U, Ayaz M, Raziq NJEJoP (2020) 6-Methoxyflavanone abates cisplatin-induced neuropathic pain apropos anti-inflammatory mechanisms: a behavioral and molecular simulation study. Eur J Pharmacol 872:172972

Article  CAS  PubMed  Google Scholar 

Akhoon BA, Pandey S, Tiwari S, Pandey R (2016) Withanolide a offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of caenorhabditis elegans. Exp Gerontol 78:47–56

Article  CAS  PubMed  Google Scholar 

Alkan Uçkun A, BarımÖz ÖJES (2020) Acute exposure to the fungicide penconazole affects some biochemical parameters in the crayfish (Astacus leptodactylus Eschscholtz, 1823). Environ Sci Pollut Res 27:35626–35637

Article  Google Scholar 

Badawy ME, Abdelgaleil SA, Mahmoud NF, Marei AE-SM (2018) Preparation and characterizations of essential oil and monoterpene nanoemulsions and acaricidal activity against two-spotted spider mite (Tetranychus urticae Koch). Int J Acarology 44:330–340

Article  Google Scholar 

Baldissera MD, Souza CF, Zanella R, Prestes OD, Meinhart AD, Da Silva AS, Baldisserotto BJCB, Toxicology PPC (2021) Behavioral impairment and neurotoxic responses of silver catfish Rhamdia quelen exposed to organophosphate pesticide trichlorfon: protective effects of diet containing rutin. Comp Biochem Physiol c: Toxicol Pharmacol 239:108871

PubMed  Google Scholar 

Bancroft JD, Layton C (2012) The Hematoxylins and Eosin Bancroft’s Theory and Practice Of Histological Techniques. Elsevier

Google Scholar 

Banni M, Messaoudi I, Said L, El Heni J, Kerkeni A, Said K (2010) Metallothionein gene expression in liver of rats exposed to cadmium and supplemented with zinc and selenium. Arch Environ Contam Toxicol 59:513–519

Article  CAS  PubMed  Google Scholar 

Barai P, Raval N, Acharya S, Borisa A, Bhatt H, Acharya N (2019) Neuroprotective effects of bergenin in Alzheimer’s disease: Investigation through molecular docking, in vitro and in vivo studies. Behav Brain Res 356:18–40

Article  CAS  PubMed  Google Scholar 

Beshay ON, Ewees MG, Abdel-Bakky MS, Hafez SMNA, Abdelrehim AB, Bayoumi AM (2020) Resveratrol reduces gentamicin-induced EMT in the kidney via inhibition of reactive oxygen species and involving TGF-β/Smad pathway. Life Sci 258:118178

Article  CAS  PubMed  Google Scholar 

Bhagat J, Singh N, Nishimura N, Shimada Y (2021) A comprehensive review on environmental toxicity of azole compounds to fish. Chemosphere 262:128335

Article  CAS  PubMed  Google Scholar 

Bielská L, Hale SE, Škulcová L (2021) A review on the stereospecific fate and effects of chiral conazole fungicides. Sci Total Environ 750:141600

Article  PubMed  Google Scholar 

Birla H, Keswani C, Rai SN, Singh SS, Zahra W, Dilnashin H, Rathore AS, Singh SP (2019) Neuroprotective effects of Withania somnifera in BPA induced-cognitive dysfunction and oxidative stress in mice. Behav Brain Funct 15:9

Article  PubMed  PubMed Central  Google Scholar 

Bojarski B, Witeska M (2020) Blood biomarkers of herbicide, insecticide, and fungicide toxicity to fish—a review. Environ Sci Pollut Res 27:19236–19250

Article  CAS  Google Scholar 

Brandebura AN, Paumier A, Onur TS, Allen NJ (2023) Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders. Nat Rev Neurosci 24:23–39

Article  CAS  PubMed  Google Scholar 

Bruce RD (1985) An up-and-down procedure for acute toxicity testing. Fundam Appl Toxicol 5:151–157

Article  CAS  PubMed  Google Scholar 

Bumbăcilă B, Putz MV (2020) Neurotoxicity of pesticides: the roadmap for the cubic mode of action. Curr Med Chem 27:54–77

Article  PubMed  Google Scholar 

Chaâbane M, Soudani N, Benjeddou K, Turki M, Ayadi Makni F, Boudawara T, Zeghal N, Ellouze Ghorbel RJT, Chemistry E (2015) The protective potential of nitraria retusa on penconazole-induced hepatic injury in adult rats. Toxicol Environ Chem 97:1253–1264

Article  Google Scholar 

Chaâbane M, Tir M, Hamdi S, Boudawara O, Jamoussi K, Boudawara T, Ghorbel RE, Zeghal N, Soudani NJB (2016) Improvement of heart redox states contributes to the beneficial effects of selenium against penconazole-induced cardiotoxicity in adult rats. Biol Trace Elem Res 169:261–270

Article  PubMed  Google Scholar 

Chaâbane M, Ghorbel I, Elwej A, Mnif H, Boudawara T, Chaâbouni SE, Zeghal N, Soudani N (2017a) Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Hum Exp Toxicol 36:854–866

Article  PubMed  Google Scholar 

Chaâbane M, Koubaa M, Soudani N, Elwej A, Grati M, Jamoussi K, Boudawara T, Ellouze Chaabouni S, Zeghal N (2017b) Nitraria retusa fruit prevents penconazole-induced kidney injury in adult rats through modulation of oxidative stress and histopathological changes. Pharm Biol 55:1061–1073

Article  PubMed  PubMed Central  Google Scholar 

Chaâbane M, Koubaa M, Soudani N, Elwej A, Grati M, Jamoussi K, Boudawara T, Ellouze Chaabouni S, Zeghal NJP (2017c) Nitraria retusa fruit prevents penconazole-induced kidney injury in adult rats through modulation of oxidative stress and histopathological changes. Pharm Biol 55:1061–1073

Article  PubMed  PubMed Central  Google Scholar 

Chaâbane M, Elwej A, Ghorbel I, Chelly S, Mnif H, Boudawara T, Chaabouni SE, Zeghal N, Soudani NJB, Pharmacotherapy, (2018) Penconazole alters redox status, cholinergic function and lung’s histoarchitecture of adult rats: reversal effect of vitamin E. Biomed Pharmacother 102:645–652

Article  PubMed  Google Scholar 

Chandra S, Chatterjee P, Dey P, Bhattacharya SJPJ (2012) Evaluation of anti-inflammatory effect of ashwagandha: a preliminary study in vitro. Pharmacognosy Journal. 4:47–49

Article  Google Scholar 

Chandra S, Roy A, Jana M, Pahan K (2019) Cinnamic acid activates PPARα to stimulate lysosomal biogenesis and lower amyloid plaque pathology in an Alzheimer’s disease mouse model. Neurobiol Dis 124:379–395

Article  CAS  PubMed  Google Scholar 

Chang S, Li X, Zheng Y, Shi H, Zhang D, Jing B, Chen Z, Qian G, Zhao G (2022) Kaempferol exerts a neuroprotective effect to reduce neuropathic pain through TLR4/NF-ĸB signaling pathway. Phytother Res 36:1678–1691

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chatterjee B, Gorain B, Mohananaidu K, Sengupta P, Mandal UK, Choudhury H (2019) Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges. Int J Pharm 565:258–268

Article  CAS  PubMed  Google Scholar 

Choudhary D, Bhattacharyya S, Bose SJJDS (2017) Efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions. J Dietary Suppl 14:599–612

Article  Google Scholar 

Chrastina, A., Baron, V.T., Abedinpour, P., Rondeau, G., Welsh, J., Borgström, P., (2018) Plumbagin-loaded nanoemulsion drug delivery formulation and evaluation of antiproliferative effect on prostate cancer cells. BioMed research international 2018.

Crépeaux G, Eidi H, David M-O, Baba-Amer Y, Tzavara E, Giros B, Authier F-J, Exley C, Shaw CA, Cadusseau J (2017) Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity. Toxicology 375:48–57

Article  PubMed  Google Scholar 

Derbalah A, El Kot G, Hamza A (2011) Control of powdery mildew in okra using cultural filtrates of certain bio-agents alone and mixed with penconazole. Archives of Phytopathology and Plant Protection 44:2012–2023

Article  CAS  Google Scholar 

Annabi A, Doghri R, Rejeb I, Dallagi Y, Bdiri Y, Lasram MM, Elgaaied A, Marrakchi R, Fazaa S, Gati A, (2017) Neuroprotective effects of curcumin against acetamiprid-induced neurotoxicity and oxidative stress in the developing male rat cerebellum: biochemical, histological, and behavioral changes. Environ Sci Pollut Res 24:27515-27524

Ding Z, Jiang Y, Liu X (2018) Nanoemulsions-based drug delivery for brain tumors, Nanotechnology-based targeted drug delivery systems for brain tumors. Elsevier

Google Scholar 

Diniz LP, Matias I, Siqueira M, Stipursky J, Gomes FCA (2019) Astrocytes and the TGF-β1 pathway in the healthy and diseased brain: a double-edged sword. Mol Neurobiol 56:4653–4679

Article  CAS  PubMed  Google Scholar 

Doorn KJ, Brevé JJ, Drukarch B, Boddeke HW, Huitinga I, Lucassen PJ, van Dam A-M (2015) Brain region-specific gene expression profiles in freshly isolated rat microglia. Front Cell Neurosci 9:84

Article  PubMed  PubMed Central  Google Scholar 

Dutra RC, Campos MM, Santos AR, Calixto JB (2016) Medicinal plants in Brazil: pharmacological studies, drug discovery, challenges and perspectives. Pharmacol Res 112:4–29

Article  CAS  PubMed  Google Schola