Klein S, Gastaldelli A, Yki-Järvinen H, Scherer PE. Why does obesity cause diabetes? Cell Metab. 2022;34(1):11–20. https://doi.org/10.1016/j.cmet.2021.12.012. Recent article on adipose tissue function in obesity.
CAS Article PubMed Google Scholar
Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet. 2011;377(9765):557–67. https://doi.org/10.1016/S0140-6736(10)62037-5.
Article PubMed PubMed Central Google Scholar
GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27. https://doi.org/10.1056/NEJMoa1614362.
Gastaldelli A, Abdul Ghani M, DeFronzo RA. Adaptation of insulin clearance to metabolic demand is a key determinant of glucose tolerance. Diabetes. 2021;70(2):377–85. https://doi.org/10.2337/db19-1152.
CAS Article PubMed Google Scholar
Smith GI, Mittendorfer B, Klein S. Metabolically healthy obesity: facts and fantasies. J Clin Invest. 2019;129(10):3978–89. https://doi.org/10.1172/JCI129186.
Article PubMed PubMed Central Google Scholar
van Vliet S, Koh HE, Patterson BW, Yoshino M, LaForest R, Gropler RJ, et al. Obesity is associated with increased basal and postprandial β-cell insulin secretion even in the absence of insulin resistance. Diabetes. 2020;69(10):2112–9. https://doi.org/10.2337/db20-0377.
CAS Article PubMed PubMed Central Google Scholar
Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2018;98(4):2133–223. https://doi.org/10.1152/physrev.00063.2017.
CAS Article PubMed PubMed Central Google Scholar
Weir GC. Glucolipotoxicity, β-cells, and diabetes: the emperor has no clothes. Diabetes. 2020;69(3):273–8. https://doi.org/10.2337/db19-0138.
CAS Article PubMed PubMed Central Google Scholar
Prentki M, Peyot ML, Masiello P, Madiraju SRM. Nutrient-induced metabolic stress, adaptation, detoxification, and toxicity in the pancreatic β-cell. Diabetes. 2020;69(3):279–90. https://doi.org/10.2337/dbi19-0014.
CAS Article PubMed Google Scholar
Wernstedt Asterholm I, Tao C, Morley TS, Wang QA, Delgado-Lopez F, Wang ZV, et al. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab. 2014;20(1):103–18. https://doi.org/10.1016/j.cmet.2014.05.005.
CAS Article PubMed Google Scholar
Beals JW, Smith GI, Shankaran M, Fuchs A, Schweitzer GG, Yoshino J, et al. Increased adipose tissue fibrogenesis, not impaired expandability, is associated with nonalcoholic fatty liver disease. Hepatology. 2021;74(3):1287–99. https://doi.org/10.1002/hep.31822.
CAS Article PubMed Google Scholar
Liu T, Sun YC, Cheng P, Shao HG. Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance. Biochem Biophys Res Commun. 2019;515(2):352–8. https://doi.org/10.1016/j.bbrc.2019.05.113.
CAS Article PubMed Google Scholar
Bays HE, Chapman RH, Grandy S, SHIELD Investigators’ Group. The relationship of body mass index to diabetes mellitus, hypertension and dyslipidaemia: comparison of data from two national surveys. Int J Clin Pract. 2007;61(5):737–47. https://doi.org/10.1111/j.1742-1241.2007.01336.x (Erratum in: Int J Clin Pract. 2007 Oct;61(10):1777-8).
CAS Article PubMed Google Scholar
Sarma S, Sockalingam S, Dash S. Obesity as a multisystem disease: trends in obesity rates and obesity-related complications. Diabetes Obes Metab. 2021;23(Suppl 1):3–16. https://doi.org/10.1111/dom.14290.
CAS Article PubMed Google Scholar
Khafagy R, Dash S. Obesity and cardiovascular disease: the emerging role of inflammation. Front Cardiovasc Med. 2021;25(8):768119. https://doi.org/10.3389/fcvm.2021.768119.
Blaha MJ, Rivera JJ, Budoff MJ, Blankstein R, Agatston A, O’Leary DH, et al. Association between obesity, high-sensitivity C-reactive protein ≥2 mg/L, and subclinical atherosclerosis: implications of JUPITER from the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2011;31(6):1430–8. https://doi.org/10.1161/ATVBAHA.111.223768.
CAS Article PubMed PubMed Central Google Scholar
Cohen RV, Pereira TV, Aboud CM, Petry TBZ, Lopes Correa JL, Schiavon CA, et al. Effect of gastric bypass vs best medical treatment on early-stage chronic kidney disease in patients with type 2 diabetes and obesity: a randomized clinical trial. JAMA Surg. 2020;155(8):e200420. https://doi.org/10.1001/jamasurg.2020.0420.
Article PubMed PubMed Central Google Scholar
Look AHEAD Research Group, Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145–54. https://doi.org/10.1056/NEJMoa1212914 (Erratum in: N Engl J Med. 2014 May 8;370(19):1866).
Look AHEAD Research Group, Gregg EW, Jakicic JM, Blackburn G, Bloomquist P, Bray GA, et al. Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol. 2016;4(11):913–21. https://doi.org/10.1016/S2213-8587(16)30162-0.
Wang J, Shen X, He S, An Y, Gong Q, Li H, Zhang B, Shuai Y, Chen Y, Hu Y, Li G. Hypertriglyceridaemia predicts subsequent long-term risk of cardiovascular events in Chinese adults: 23-year follow-up of the Daqing Diabetes Study. Diabetes Metab Res Rev. 2019;35(6):e3163. https://doi.org/10.1002/dmrr.3163.
CAS Article PubMed Google Scholar
Strelitz J, Lawlor ER, Wu Y, Estlin A, Nandakumar G, Ahern AL, et al. Association between weight change and incidence of cardiovascular disease events and mortality among adults with type 2 diabetes: a systematic review of observational studies and behavioural intervention trials. Diabetologia. 2022;65(3):424–39. https://doi.org/10.1007/s00125-021-05605-1.
Kristensen SL, Rørth R, Jhund PS, Docherty KF, Sattar N, Preiss D, et al. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. Lancet Diabetes Endocrinol. 2019;7(10):776–85. https://doi.org/10.1016/S2213-8587(19)30249-9 (Erratum in: Lancet Diabetes Endocrinol. 2020 Mar;8(3):e2).
CAS Article PubMed Google Scholar
Schauer PR, Kashyap SR, Wolski K, Brethauer SA, Kirwan JP, Pothier CE, et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med. 2012;366(17):1567–76. https://doi.org/10.1056/NEJMoa1200225.
CAS Article PubMed PubMed Central Google Scholar
Amouyal C, Andreelli F. Increasing GLP-1 circulating levels by bariatric surgery or by GLP-1 receptor agonists therapy: why are the clinical consequences so different? J Diabetes Res. 2016;2016:5908656. https://doi.org/10.1155/2016/5908656.
CAS Article PubMed PubMed Central Google Scholar
Thorens B. Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci U S A. 1992;89(18):8641–5. https://doi.org/10.1073/pnas.89.18.8641.
CAS Article PubMed PubMed Central Google Scholar
Drucker DJ. GLP-1 physiology informs the pharmacotherapy of obesity. Mol Metab. 2022;57:101351. https://doi.org/10.1016/j.molmet.2021.101351. (Interesting and current review on the clinical physiology of GLP-1 and GLP-1 RA to understand their use in the treatment of obesity)
CAS Article PubMed Google Scholar
Nauck MA, Quast DR, Wefers J, Meier JJ. GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art. Mol Metab. 2021;46:101102. https://doi.org/10.1016/j.molmet.2020.101102. (Complete review for the clinician of the use of GLPI-RA)
CAS Article PubMed Google Scholar
Vilsbøll T, Krarup T, Madsbad S, Holst JJ. Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects. Regul Pept. 2003;114(2–3):115–21. https://doi.org/10.1016/s0167-0115(03)00111-3.
Nauck MA, Meier JJ. GIP and GLP-1: stepsiblings rather than monozygotic twins within the incretin family. Diabetes. 2019;68(5):897–900. https://doi.org/10.2337/dbi19-0005.
CAS Article PubMed Google Scholar
Christensen MB, Gasbjerg LS, Heimbürger SM, Stensen S, Vilsbøll T, Knop FK. GIP’s involvement in the pathophysiology of type 2 diabetes. Peptides. 2020;125:170178. https://doi.org/10.1016/j.peptides.2019.170178.
CAS Article PubMed Google Scholar
Holst JJ, Andersen DB, Grunddal KV. Actions of glucagon-like peptide-1 receptor ligands in the gut. Br J Pharmacol. 2022;179(4):727–42. https://doi.org/10.1111/bph.15611.
CAS Article PubMed Google Scholar
Azmy Nabeh O, Ishak Attallah M, El-Sayed E-G. The pivotal relation between glucagon-like peptides, NFκB and inflammatory bowel disease. Clin Exp Pharmacol Physiol. 2020;47(10):1641–8. https://doi.org/10.1111/1440-1681.13361.
CAS Article PubMed Google Scholar
Nauck MA, Quast DR, Wefers J, Pfeiffer AFH. The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: a pathophysiological update. Diabetes Obes Metab. 2021;23(Suppl 3):5–29. https://doi.org/10.1111/dom.14496. (Excellent review on the cardiovascular actions of GLP-1RA)
CAS Article PubMed Google Scholar
Verdich C, Flint A, Gutzwiller JP, Näslund E, Beglinger C, Hellström PM, et al. A meta-analysis of the effect of glucagon-like peptide-1 (7–36) amide on ad libitum energy intake in humans. J Clin Endocrinol Metab. 2001;86(9):4382–9. https://doi.org/10.1210/jcem.86.9.7877.
CAS Article PubMed Google Scholar
Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, et al. Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020;11(1):467. https://doi.org/10.1038/s41467-020-1430
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