Bachmann S, Schröder J (2017) Neurological soft signs in schizophrenia: an update on the state- versus trait-perspective. Front Psych 8:272

Article  Google Scholar 

Hirjak D, Thomann PA, Kubera KM, Wolf ND, Sambataro F, Wolf RC (2015) Motor dysfunction within the schizophrenia-spectrum: a dimensional step towards an underappreciated domain. Schizophr Res 169:217–233

PubMed  Article  Google Scholar 

Northoff G, Hirjak D (2020) All roads lead to the motor cortex: Psychomotor mechanisms and their biochemical modulation in psychiatric disorders.

Walther S, van Harten PN, Waddington JL, Cuesta MJ, Peralta V, Dupin L, Foucher JR, Sambataro F, Morrens M, Kubera KM, Pieters LE, Stegmayer K, Strik W, Wolf RC, Hirjak D (2020) Movement disorder and sensorimotor abnormalities in schizophrenia and other psychoses—European consensus on assessment and perspectives. Euro Neuropsychopharmacol 38:25–39

CAS  Article  Google Scholar 

Sanislow CA, Ferrante M, Pacheco J, Rudorfer MV, Morris SE (2019) Advancing translational research using NIMH research domain criteria and computational methods. Neuron 101:779–782

CAS  PubMed  Article  Google Scholar 

Peralta V, Cuesta MJ (2017) Motor abnormalities: from neurodevelopmental to neurodegenerative through “functional” (neuro)psychiatric disorders. Schizophr Bull 43:956–971

PubMed  PubMed Central  Article  Google Scholar 

Walther S, Strik W (2012) Motor symptoms and schizophrenia. Neuropsychobiology 66:77–92

PubMed  Article  Google Scholar 

Chan RC, Xu T, Heinrichs RW, Yu Y, Gong QY (2010) Neurological soft signs in non-psychotic first-degree relatives of patients with schizophrenia: a systematic review and meta-analysis. Neurosci Biobehav Rev 34:889–896

PubMed  Article  Google Scholar 

Hirjak D, Kubera KM, Thomann PA, Wolf RC (2018) Motor dysfunction as an intermediate phenotype across schizophrenia and other psychotic disorders: progress and perspectives. Schizophr Res 200:26–34

PubMed  Article  Google Scholar 

Hirjak D, Meyer-Lindenberg A, Fritze S, Sambataro F, Kubera KM, Wolf RC (2018) Motor dysfunction as research domain across bipolar, obsessive-compulsive and neurodevelopmental disorders. Neurosci Biobehav Rev 95:315–335

PubMed  Article  Google Scholar 

Hirjak D, Meyer-Lindenberg A, Kubera KM, Thomann PA, Wolf RC (2018) Motor dysfunction as research domain in the period preceding manifest schizophrenia: a systematic review. Neurosci Biobehav Rev 87:87–105

PubMed  Article  Google Scholar 

Zhao Q, Li Z, Huang J, Yan C, Dazzan P, Pantelis C, Cheung EF, Lui SS, Chan RC (2014) Neurological soft signs are not “soft” in brain structure and functional networks: evidence from ale meta-analysis. Schizophr Bull 40:626–641

PubMed  Article  Google Scholar 

Andreasen NC (2000) Schizophrenia: the fundamental questions. Brain Res Brain Res Rev 31:106–112

CAS  PubMed  Article  Google Scholar 

Peralta V, Cuesta MJ (2011) Neuromotor abnormalities in neuroleptic-naive psychotic patients: antecedents, clinical correlates, and prediction of treatment response. Compr Psychiatry 52:139–145

PubMed  Article  Google Scholar 

Waddington JL (2020) Psychosis in Parkinson’s disease and parkinsonism in antipsychotic-naive schizophrenia spectrum psychosis: clinical, nosological and pathobiological challenges. Acta Pharmacol Sin 41:464–470

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sambataro F, Fritze S, Rashidi M, Topor CE, Kubera KM, Wolf RC, Hirjak D (2020) Moving forward: distinct sensorimotor abnormalities predict clinical outcome after 6 months in patients with schizophrenia. Euro Neuropsychopharmacol 36:72–82

CAS  Article  Google Scholar 

Janno S, Holi M, Tuisku K, Wahlbeck K (2004) Prevalence of neuroleptic-induced movement disorders in chronic schizophrenia inpatients. Am J Psychiatry 161:160–163

PubMed  Article  Google Scholar 

Hirjak D, Meyer-Lindenberg A, Sambataro F, Fritze S, Kukovic J, Kubera KM, Wolf RC (2021) Progress in sensorimotor neuroscience of schizophrenia spectrum disorders: Lessons learned and future directions. Progress in neuro-psychopharmacology & biological psychiatry 111:110370

Hirjak D, Kubera KM, Northoff G, Fritze S, Bertolino AL, Topor CE, Schmitgen MM, Wolf RC (2019) Cortical contributions to distinct symptom dimensions of catatonia. Schizophr Bull 45:1184–1194

PubMed  PubMed Central  Article  Google Scholar 

Hirjak D, Rashidi M, Kubera KM, Northoff G, Fritze S, Schmitgen MM, Sambataro F, Calhoun VD, Wolf RC (2020) Multimodal magnetic resonance imaging data fusion reveals distinct patterns of abnormal brain structure and function in catatonia. Schizophr Bull 46:202–210

PubMed  Article  Google Scholar 

Oldfield RC (1971) The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia 9:97–113

CAS  PubMed  Article  Google Scholar 

Sass H., Wittchen H.U., Zaudig M., I. H (2003) Diagnostisches und statistisches manual psychischer störungen dsm-iv-tr: Textrevision. Hogrefe Verlag; Auflage: 1 (1. Januar 2003)

Hirjak D, Kubera KM, Northoff G, Fritze S, Bertolino AL, Topor CE, Schmitgen MM, Wolf RC (2019) Cortical contributions to distinct symptom dimensions of catatonia. Schizophr Bull

Hirjak D, Rashidi M, Kubera KM, Northoff G, Fritze S, Schmitgen MM, Sambataro F, Calhoun VD, Wolf RC (2019) Multimodal magnetic resonance imaging data fusion reveals distinct patterns of abnormal brain structure and function in catatonia. Schizophrenia bulletin

Leucht S, Samara M, Heres S, Patel MX, Furukawa T, Cipriani A, Geddes J, Davis JM (2015) Dose equivalents for second-generation antipsychotic drugs: the classical mean dose method. Schizophr Bull 41:1397–1402

PubMed  PubMed Central  Article  Google Scholar 

Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (panss) for schizophrenia. Schizophr Bull 13:261–276

CAS  PubMed  Article  Google Scholar 

Kay SR (1990) Positive-negative symptom assessment in schizophrenia: psychometric issues and scale comparison. Psychiatr Q 61:163–178

CAS  PubMed  Article  Google Scholar 

Andersen J, Larsen JK, Kørner A, Nielsen BM, Schultz V, Behnke K, Bjørum N (1986) The brief psychiatric rating scale: Schizophrenia, reliability and validity studies. Nordisk Psykiatrisk Tidsskrift 40:2.:135–138

Overall JE, Gorham DR (1962) The brief psychiatric rating scale (bprs). Psychological reports 10:799–812 10:799–812.

Berk M, Ng F, Dodd S, Callaly T, Campbell S, Bernardo M, Trauer T (2008) The validity of the cgi severity and improvement scales as measures of clinical effectiveness suitable for routine clinical use. J Eval Clin Pract 14:979–983

PubMed  Article  Google Scholar 

Guy W (1976) Assessment manual for psychopharmacology. Rockville/ Ts, NIH Psychopharmacology Research:76–338.

Grootenboer EM, Giltay EJ, van der Lem R, van Veen T, van der Wee NJ, Zitman FG (2012) Reliability and validity of the global assessment of functioning scale in clinical outpatients with depressive disorders. J Eval Clin Pract 18:502–507

PubMed  Article  Google Scholar 

DSM-III.R. DKuDddusMpSr (1989) Gaf-skala: Global assessment of functioning scale. In:Beltz, Weinheim, Basel.

Hurford IM, Marder SR, Keefe RS, Reise SP, Bilder RM (2011) A brief cognitive assessment tool for schizophrenia: construction of a tool for clinicians. Schizophr Bull 37:538–545

PubMed  Article  Google Scholar 

Bachmann S, Bottmer C, Schroder J (2005) Neurological soft signs in first-episode schizophrenia: a follow-up study. Am J Psychiatry 162:2337–2343

PubMed  Article  Google Scholar 

Schroder J, Niethammer R, Geider FJ, Reitz C, Binkert M, Jauss M, Sauer H (1991) Neurological soft signs in schizophrenia. Schizophr Res 6:25–30

CAS  PubMed  Article  Google Scholar 

Simpson GM, Angus JW (1970) A rating scale for extrapyramidal side effects. Acta Psychiatr Scand Suppl 212:11–19

CAS  PubMed  Article  Google Scholar 

Hirjak D, Thomann PA, Northoff G, Kubera KM, Wolf RC (2016) Ncr-skala - deutsche version der northoff catatonia rating scale (ncrs-dv) - ein validiertes messinstrument zur erfassung katatoner symptome. Der Nervenarzt:(im Druck)

Barnes TR (1989) A rating scale for drug-induced akathisia. Br J Psychiatry 154:672–676

CAS  PubMed  Article  Google Scholar 

Barnes TR (2003) The Barnes akathisia rating scale–revisited. J Psychopharmacol 17:365–370

PubMed  Article  Google Scholar 

Guy E (1976) Abnormal involuntary movement scale., Rockwille, MD

Burdick KE, Russo M, Frangou S, Mahon K, Braga RJ, Shanahan M, Malhotra AK (2014) Empirical evidence for discrete neurocognitive subgroups in bipolar disorder: clinical implications. Psychol Med 44:3083–3096

CAS  PubMed  PubMed Central  Article  Google Scholar 

Aranganayagi S, Thangavel K (2007) Clustering categorical data using silhouette coefficient as a relocating measure. In: International conference on computational intelligence and multimedia applications (ICCIMA 2007). IEEE, p 13–17

Halstead SM, Barnes TR, Speller JC (1994) Akathisia: prevalence and associated dysphoria in an in-patient population with chronic schizophrenia. Br J Psychiatry 164:177–183

CAS  PubMed  Article  Google Scholar 

Peralta V, Moreno-Izco L, Sanchez-Torres A, García de Jalón E, Campos MS, Cuesta MJ (2014) Characterization of the deficit syndrome in drug-naive schizophrenia patients: the role of spontaneous movement disorders and neurological soft signs. Schizophr Bull 40:214–224

PubMed  Article  Google Scholar 

Jahn T, Hubmann W, Karr M, Mohr F, Schlenker R, Heidenreich T, Cohen R, Schröder J (2006) Motoric neurological soft signs and psychopathological symptoms in schizophrenic psychoses. Psychiatry Res 142:191–199

PubMed  Article  Google Scholar 

McCreadie RG, Thara R, Kamath S, Padmavathy R, Latha S, Mathrubootham N, Menon MS (1996) Abnormal movements in never-medicated Indian patients with schizophrenia. Br J Psychiatry 168:221–226

CAS  PubMed  Article  Google Scholar 

Stubbs JH, Halstead SM (2000) Pseudoakathisia: a review and two case reports. Compr Psychiatry 41:70–72

CAS  PubMed  Article  Google Scholar 

Hirjak D, Kubera KM, Wolf RC, Northoff G (2020) Going back to Kahlbaum’s psychomotor (and gabaergic) origins: Is catatonia more than just a motor and dopaminergic syndrome? Schizophr Bull 46:272–285

PubMed  Article  Google Scholar 

Northoff G (2002) What catatonia can tell us about "top-down modulation": A neuropsychiatric hypothesis. The Behavioral and brain sciences 25:555–577; discussion 578–604

Northoff G (2002) Catatonia and neuroleptic malignant syndrome: Psychopathology and pathophysiology. Journal of neural transmission (Vienna, Austria : 1996) 109:1453–1467

Wasserthal J, Maier-Hein KH, Neher PF, Wolf RC, Northoff G, Waddington JL, Kubera KM, Fritze S, Harneit A, Geiger LS, Tost H, Hirjak D (2021) White matter microstructure alterations in cortico-striatal networks are associated with parkinsonism in schizophrenia spectrum disorders. Euro Neuropsychopharmacol 50:64–74

CAS  Article