Alva S, Castorino K, Cho H, Ou J. Feasibility of continuous ketone monitoring in subcutaneous tissue using a ketone sensor. J Diabetes Sci Technol. 2021;15(4):768–74. https://doi.org/10.1177/19322968211008185.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Zhang JY, Shang T, Koliwad SK, Klonoff DC. Continuous ketone monitoring: a new paradigm for physiologic monitoring. J Diabetes Sci Technol. 2021;15(4):775–80. https://doi.org/10.1177/19322968211009860.

Article  PubMed  PubMed Central  Google Scholar 

Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev. 1999;15(6):412–26. https://doi.org/10.1002/(sici)1520-7560(199911/12)15:6%3c412::aid-dmrr72%3e3.0.co;2-8.

CAS  Article  PubMed  Google Scholar 

Dhatariya KK, Glaser NS, Codner E, Umpierrez GE. Diabetic ketoacidosis. Nat Rev Dis Primers. 2020;6(1):40. https://doi.org/10.1038/s41572-020-0165-1 (Published 2020 May 14).

Article  PubMed  Google Scholar 

Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009;32(7):1335–43. https://doi.org/10.2337/dc09-9032.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Balasubramanyam A, Nalini R, Hampe CS, Maldonado M. Syndromes of ketosis-prone diabetes mellitus. Endocr Rev. 2008;29(3):292–302. https://doi.org/10.1210/er.2007-0026.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Dhatariya K. Blood Ketones: measurement, interpretation, limitations, and utility in the management of diabetic ketoacidosis. Rev Diabet Stud. 2016;13(4):217–25. https://doi.org/10.1900/RDS.2016.13.217.

Article  PubMed  Google Scholar 

Nguyen KT, Xu NY, Zhang JY, et al. Continuous ketone monitoring consensus report 2021 [published online ahead of print, 2021 Oct 4]. J Diabetes Sci Technol. 2021;19322968211042656. https://doi.org/10.1177/19322968211042656

Harris S, Ng R, Syed H, Hillson R. Near patient blood ketone measurements and their utility in predicting diabetic ketoacidosis. Diabet Med. 2005;22(2):221–4. https://doi.org/10.1111/j.1464-5491.2004.01374.x.

CAS  Article  PubMed  Google Scholar 

Misra S, Oliver NS. Utility of ketone measurement in the prevention, diagnosis and management of diabetic ketoacidosis. Diabet Med. 2015;32(1):14–23. https://doi.org/10.1111/dme.12604.

CAS  Article  PubMed  Google Scholar 

Myers SR, Glaser NS, Trainor JL, et al. Frequency and risk factors of acute kidney injury during diabetic ketoacidosis in children and association with neurocognitive outcomes. JAMA Netw Open. 2020;3(12):e2025481. https://doi.org/10.1001/jamanetworkopen.2020.25481 (Published 2020 Dec 1).

Article  PubMed  PubMed Central  Google Scholar 

Sheikh-Ali M, Karon BS, Basu A, et al. Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis? Diabetes Care. 2008;31(4):643–7. https://doi.org/10.2337/dc07-1683.

CAS  Article  PubMed  Google Scholar 

Patel MP, Ahmed A, Gunapalan T, Hesselbacher SE. Use of sodium bicarbonate and blood gas monitoring in diabetic ketoacidosis: a review. World J Diabetes. 2018;9(11):199–205. https://doi.org/10.4239/wjd.v9.i11.199.

Article  PubMed  PubMed Central  Google Scholar 

Ma OJ, Rush MD, Godfrey MM, Gaddis G. Arterial blood gas results rarely influence emergency physician management of patients with suspected diabetic ketoacidosis. Acad Emerg Med. 2003;10(8):836–41. https://doi.org/10.1111/j.1553-2712.2003.tb00625.x.

Article  PubMed  Google Scholar 

Elisaf MS, Tsatsoulis AA, Katopodis KP, Siamopoulos KC. Acid-base and electrolyte disturbances in patients with diabetic ketoacidosis. Diabetes Res Clin Pract. 1996;34(1):23–7. https://doi.org/10.1016/s0168-8227(96)01332-0.

CAS  Article  PubMed  Google Scholar 

Klocker AA, Phelan H, Twigg SM, Craig ME. Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in type 1 diabetes: a systematic review. Diabet Med. 2013;30(7):818–24. https://doi.org/10.1111/dme.12136.

CAS  Article  PubMed  Google Scholar 

Kraus FB, Kocijancic M, Kluttig A, Ludwig-Kraus B. Test validation, method comparison and reference range for the measurement of β-hydroxybutyrate in peripheral blood samples. Biochem Med (Zagreb). 2020;30(1):010707. https://doi.org/10.11613/BM.2020.010707.

Article  Google Scholar 

Byrne HA, Tieszen KL, Hollis S, Dornan TL, New JP. Evaluation of an electrochemical sensor for measuring blood ketones. Diabetes Care. 2000;23(4):500–3. https://doi.org/10.2337/diacare.23.4.500.

CAS  Article  PubMed  Google Scholar 

Taboulet P, Haas L, Porcher R, et al. Urinary acetoacetate or capillary beta-hydroxybutyrate for the diagnosis of ketoacidosis in the Emergency Department setting. Eur J Emerg Med. 2004;11(5):251–8. https://doi.org/10.1097/00063110-200410000-00003.

Article  PubMed  Google Scholar 

Laffel LM, Wentzell K, Loughlin C, Tovar A, Moltz K, Brink S. Sick day management using blood 3-hydroxybutyrate (3-OHB) compared with urine ketone monitoring reduces hospital visits in young people with T1DM: a randomized clinical trial. Diabet Med. 2006;23(3):278–84. https://doi.org/10.1111/j.1464-5491.2005.01771.x.

CAS  Article  PubMed  Google Scholar 

Weber C, Kocher S, Neeser K, Joshi SR. Prevention of diabetic ketoacidosis and self-monitoring of ketone bodies: an overview. Curr Med Res Opin. 2009;25(5):1197–207. https://doi.org/10.1185/03007990902863105.

Article  PubMed  Google Scholar 

Vanelli M, Chiari G, Capuano C, Iovane B, Bernardini A, Giacalone T. The direct measurement of 3-beta-hydroxy butyrate enhances the management of diabetic ketoacidosis in children and reduces time and costs of treatment. Diabetes Nutr Metab. 2003;16(5–6):312–6.

CAS  PubMed  Google Scholar 

Vanelli M, Mastrorilli C, Fainardi V, et al. Clinical utility of beta-hydroxybutyrate measurement in the management of physiological ketosis at home in children under 5. Acta Biomed. 2019;90(2):215–20 (Published 2019 May 23).

CAS  PubMed  Google Scholar 

Ghimire P, Dhamoon AS. Ketoacidosis. [Updated 2021 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534848/

Qiao Y, Gao Z, Liu Y, et al. Breath ketone testing: a new biomarker for diagnosis and therapeutic monitoring of diabetic ketosis. Biomed Res Int. 2014;2014:869186. https://doi.org/10.1155/2014/869186.

Article  PubMed  PubMed Central  Google Scholar 

Gosmanov AR, Gosmanova EO, Dillard-Cannon E. Management of adult diabetic ketoacidosis. Diabetes Metab Syndr Obes. 2014;7:255–64. https://doi.org/10.2147/DMSO.S50516 (Published 2014 Jun 30).

CAS  Article  PubMed  PubMed Central  Google Scholar 

Arora S, Henderson SO, Long T, Menchine M. Diagnostic accuracy of point-of-care testing for diabetic ketoacidosis at emergency-department triage: -hydroxybutyrate versus the urine dipstick. Diabetes Care. 2011;34(4):852–4. https://doi.org/10.2337/dc10-1844.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Tremblay ES, Millington K, Monuteaux MC, Bachur RG, Wolfsdorf JI. Plasma β-hydroxybutyrate for the diagnosis of diabetic ketoacidosis in the Emergency Department. Pediatr Emerg Care. 2021;37(12):e1345–50. https://doi.org/10.1097/PEC.0000000000002035

Dhatariya KK, Vellanki P. Treatment of diabetic ketoacidosis (DKA)/hyperglycemic hyperosmolar state (HHS): novel advances in the management of hyperglycemic crises (UK versus USA). Curr Diab Rep. 2017;17(5):33. https://doi.org/10.1007/s11892-017-0857-4.

Article  PubMed  PubMed Central  Google Scholar 

Orsini-Federici M, Akwi JA, Canonico V, et al. Early detection of insulin deprivation in continuous subcutaneous insulin infusion-treated patients with type 1 diabetes. Diabetes Technol Ther. 2006;8(1):67–75. https://doi.org/10.1089/dia.2006.8.67.

CAS  Article  PubMed  Google Scholar 

Neu A, Hofer SE, Karges B, et al. Ketoacidosis at diabetes onset is still frequent in children and adolescents: a multicenter analysis of 14,664 patients from 106 institutions. Diabetes Care. 2009;32(9):1647–8. https://doi.org/10.2337/dc09-0553.

Article  PubMed  PubMed Central  Google Scholar 

Rewers A, Klingensmith G, Davis C, et al. Presence of diabetic ketoacidosis at diagnosis of diabetes mellitus in youth: the Search for Diabetes in Youth study. Pediatrics. 2008;121(5):e1258–66. https://doi.org/10.1542/peds.2007-1105.

Article  PubMed  Google Scholar 

Scibilia J, Finegold D, Dorman J, Becker D, Drash A. Why do children with diabetes die? Acta Endocrinol Suppl (Copenh). 1986;279:326–33. https://doi.org/10.1530/acta.0.112s326.

CAS  Article  Google Scholar 

Cameron FJ, Scratch SE, Nadebaum C, et al. Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children. Diabetes Care. 2014;37(6):1554–62. https://doi.org/10.2337/dc13-1904.

Article  PubMed  PubMed Central  Google Scholar 

Wolfsdorf J, Glaser N, Sperling MA, American Diabetes Association. Diabetic ketoacidosis in infants, children, and adolescents: a consensus statement from the American Diabetes Association. Diabetes Care. 2006;29(5):1150–9. https://doi.org/10.2337/diacare.2951150.

Article  PubMed  Google Scholar 

Rosenbloom AL. The management of diabetic ketoacidosis in children. Diabetes Ther. 2010;1(2):103–20. https://doi.org/10.1007/s13300-010-0008-2.

CAS  Article  PubMed  Google Scholar 

Iglay K, Hannachi H, Joseph Howie P, et al. Prevalence and co-prevalence of comorbidities among patients with type 2 diabetes mellitus. Curr Med Res Opin. 2016;32(7):1243–52. https://doi.org/10.1185/03007995.2016.1168291.

Article  PubMed  Google Scholar 

Klimek P, Kautzky-Willer A, Chmiel A, Schiller-Frühwirth I, Thurner S. Quantification of diabetes comorbidity risks across life using nation-wide big claims data. PLoS Comput Biol. 2015;11(4):e1004125. https://doi.org/10.1371/journal.pcbi.1004125 (Published 2015 Apr 9).

CAS  Article  PubMed  PubMed Central  Google Scholar 

Dagogo-Jack S, Alberti KGMM. Management of diabetes mellitus in surgical patients. Diabetes Spectr. 2002;15(1):44–8. https://doi.org/10.2337/diaspect.15.1.44.

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