Gainetdinov, R. R., Premont, R. T., Bohn, L. M., Lefkowitz, R. J. & Caron, M. G. Desensitization of G protein-coupled receptors and neuronal functions. Annu. Rev. Neurosci. 27, 107–144 (2004).
CAS PubMed Article Google Scholar
Abramow-Newerly, M., Roy, A. A., Nunn, C. & Chidiac, P. RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins. Cell Signal. 18, 579–591 (2006).
CAS PubMed Article Google Scholar
Hilger, D., Masureel, M. & Kobilka, B. K. Structure and dynamics of GPCR signaling complexes. Nat. Struct. Mol. Biol. 25, 4–12 (2018).
CAS PubMed PubMed Central Article Google Scholar
Collett, B. J. Opioid tolerance: the clinical perspective. Br. J. Anaesth. 81, 58–68 (1998).
CAS PubMed Article Google Scholar
Martyn, J. A. J., Mao, J. & Bittner, E. A. Opioid tolerance in critical illness. N. Engl. J. Med. 380, 365–378 (2019).
CAS PubMed PubMed Central Article Google Scholar
Colvin, L. A., Bull, F. & Hales, T. G. Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia. Lancet 393, 1558–1568 (2019).
Darcq, E. & Kieffer, B. L. Opioid receptors: drivers to addiction? Nat. Rev. Neurosci. 19, 499–514 (2018).
CAS PubMed Article Google Scholar
Matthes, H. W. et al. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene. Nature 383, 819–823 (1996).
CAS PubMed Article Google Scholar
Williams, J. T. et al. Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharm. Rev. 65, 223–254 (2013).
PubMed PubMed Central Article CAS Google Scholar
Corder, G. et al. Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia. Nat. Med. 23, 164–173 (2017).
CAS PubMed PubMed Central Article Google Scholar
Shenoy, S. K. & Lefkowitz, R. J. β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol. Sci. 32, 521–533 (2011).
CAS PubMed PubMed Central Article Google Scholar
Bohn, L. M., Gainetdinov, R. R., Lin, F. T., Lefkowitz, R. J. & Caron, M. G. μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence. Nature 408, 720–723 (2000).
CAS PubMed Article Google Scholar
Gillis, A. et al. Critical assessment of G protein-biased agonism at the μ-opioid receptor. Trends Pharmacol. Sci. 41, 947–959 (2020).
CAS PubMed Article Google Scholar
Terzi, D., Cao, Y., Agrimaki, I., Martemyanov, K. A. & Zachariou, V. R7BP modulates opiate analgesia and tolerance but not withdrawal. Neuropsychopharmacology 37, 1005–1012 (2012).
CAS PubMed Article Google Scholar
Wang, Y. et al. Blockade of PDGFR-β activation eliminates morphine analgesic tolerance. Nat. Med. 18, 385–387 (2012).
PubMed PubMed Central Article CAS Google Scholar
Inoue, M. & Ueda, H. Protein kinase C-mediated acute tolerance to peripheral μ-opioid analgesia in the bradykinin-nociception test in mice. J. Pharmacol. Exp. Ther. 293, 662–669 (2000).
Zhou, J. et al. Molecular mechanisms of opioid tolerance: from opioid receptors to inflammatory mediators (review). Exp. Ther. Med. 22, 1004 (2021).
Wang, D. et al. Genetic behavioral screen identifies an orphan anti-opioid system. Science https://doi.org/10.1126/science.aau2078 (2019).
Minevich, G., Park, D. S., Blankenberg, D., Poole, R. J. & Hobert, O. CloudMap: a cloud-based pipeline for analysis of mutant genome sequences. Genetics 192, 1249–1269 (2012).
CAS PubMed PubMed Central Article Google Scholar
Zhong, Y., Gu, L. J., Sun, X. G., Yang, S. H. & Zhang, X. H. Comprehensive analysis of patched domain-containing genes reveals a unique evolutionary pattern. Genet. Mol. Res. 13, 7318–7331 (2014).
CAS PubMed Article Google Scholar
Tora, D. et al. Cellular functions of the autism risk factor PTCHD1 in mice. J. Neurosci. 37, 11993–12005 (2017).
CAS PubMed PubMed Central Article Google Scholar
Wells, M. F., Wimmer, R. D., Schmitt, L. I., Feng, G. & Halassa, M. M. Thalamic reticular impairment underlies attention deficit in Ptchd1Y/− mice. Nature 532, 58–63 (2016).
CAS PubMed PubMed Central Article Google Scholar
Noor, A. et al. Disruption at the PTCHD1 locus on Xp22.11 in autism spectrum disorder and intellectual disability. Sci. Transl. Med. 2, 49ra68 (2010).
PubMed PubMed Central Article CAS Google Scholar
Hawrylycz, M. J. et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature 489, 391–399 (2012).
CAS PubMed PubMed Central Article Google Scholar
Ung, D. C. et al. Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse. Mol. Psychiatry 23, 1356–1367 (2018).
CAS PubMed Article Google Scholar
Matsui, A., Jarvie, B. C., Robinson, B. G., Hentges, S. T. & Williams, J. T. Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal. Neuron 82, 1346–1356 (2014).
CAS PubMed PubMed Central Article Google Scholar
Nestler, E. J. Is there a common molecular pathway for addiction? Nat. Neurosci. 8, 1445–1449 (2005).
CAS PubMed Article Google Scholar
Khomula, E. V., Araldi, D., Bonet, I. J. M. & Levine, J. D. Opioid-induced hyperalgesic priming in single nociceptors. J. Neurosci. 41, 31–46 (2021).
CAS PubMed PubMed Central Article Google Scholar
Claing, A., Laporte, S. A., Caron, M. G. & Lefkowitz, R. J. Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and β-arrestin proteins. Prog. Neurobiol. 66, 61–79 (2002).
CAS PubMed Article Google Scholar
Li, X., Saha, P., Li, J., Blobel, G. & Pfeffer, S. R. Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2. Proc. Natl Acad. Sci. USA 113, 10079–10084 (2016).
CAS PubMed PubMed Central Article Google Scholar
Zhang, Y. et al. Structural basis for cholesterol transport-like activity of the hedgehog receptor patched. Cell 175, 1352–1364 e14 (2018).
CAS PubMed PubMed Central Article Google Scholar
Qiu, Y., Wang, Y., Law, P. Y., Chen, H. Z. & Loh, H. H. Cholesterol regulates μ-opioid receptor-induced β-arrestin 2 translocation to membrane lipid rafts. Mol. Pharmacol. 80, 210–218 (2011).
CAS PubMed PubMed Central Article Google Scholar
Barter, P. J., Brandrup-Wognsen, G., Palmer, M. K. & Nicholls, S. J. Effect of statins on HDL-C: a complex process unrelated to changes in LDL-C: analysis of the VOYAGER Database. J. Lipid Res. 51, 1546–1553 (2010).
CAS PubMed PubMed Central Article Google Scholar
McTaggart, F. & Jones, P. Effects of statins on high-density lipoproteins: a potential contribution to cardiovascular benefit. Cardiovasc. Drugs Ther. 22, 321–338 (2008).
CAS PubMed PubMed Central Article Google Scholar
Niu, Z. et al. Melanocortin 4 receptor antagonists attenuates morphine antinociceptive tolerance, astroglial activation and cytokines expression in the spinal cord of rat. Neurosci. Lett. 529, 112–117 (2012).
CAS PubMed Article Google Scholar
Lamberts, J. T., Rosenthal, L. D., Jutkiewicz, E. M. & Traynor, J. R. Role of the guanine nucleotide binding protein, Gαo, in the development of morphine tolerance and dependence. Psychopharmacol. (Berl.) 235, 71–82 (2018).
Sanna, M. D., Borgonetti, V. & Galeotti, N. μ Opioid receptor-triggered Notch-1 activation contributes to morphine tolerance: role of neuron–glia communication. Mol. Neurobiol. 57, 331–345 (2020).
CAS PubMed Article Google Scholar
Toda, N., Kishioka, S., Hatano, Y. & Toda, H. Modulation of opioid actions by nitric oxide signaling. Anesthesiology 110, 166–181 (2009).
CAS PubMed Article Google Scholar
Vidal, B. et al. An atlas of Caenorhabditis elegans chemoreceptor expression. PLoS Biol. 16, e2004218 (2018).
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