Delta variant (B.1.617.2) of SARS-CoV-2: current understanding of infection, transmission, immune escape, and mutational landscape

Abu-Raddad LJ, Chemaitelly H, Yassine HM et al (2021) Pfizer-BioNTech mRNA BNT162b2 Covid-19 vaccine protection against variants of concern after one versus two doses. J Travel Med 28:taab083

PubMed  PubMed Central  Article  Google Scholar 

Antony P, Vijayan R (2021) Molecular dynamics simulation study of the interaction between human angiotensin converting enzyme 2 and spike protein receptor binding domain of the SARS-CoV-2 B. 1.617 Variant. Biomolecules 11:1244

CAS  PubMed  PubMed Central  Article  Google Scholar 

Shiehzadegan S, Alaghemand N, Fox M et al (2021) Analysis of the Delta variant B. 1.617. 2 COVID-19. Clin Pract 11:778–784

PubMed  PubMed Central  Article  Google Scholar 

Baral P, Bhattarai N, Hossen ML et al (2021) Mutation-induced changes in the receptor-binding interface of the SARS-CoV-2 Delta variant B. 1.617. 2 and implications for immune evasion. Biochem Biophys Res Commun 574:14–19

CAS  PubMed  PubMed Central  Article  Google Scholar 

Beck DA, Alonso DO, Inoyama D et al (2008) The intrinsic conformational propensities of the 20 naturally occurring amino acids and reflection of these propensities in proteins. Proc Natl Acad Sci USA 105:12259–12264

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bernal JL et al (2021) Effectiveness of Covid-19 vaccines against the B. 1.617. 2 (Delta) variant. N Engl J Med 385:585–594

CAS  Article  Google Scholar 

Bhattacharya M, Sharma AR, Dhama K et al (2022) Omicron variant (B. 1.1. 529) of SARS-CoV-2: understanding mutations in the genome, S-glycoprotein, and antibody-binding regions. GeroScience 44:619–637

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bruxvoort KJ, Sy LS, Qian L, Ackerson BK et al (2021) Effectiveness of mRNA-1273 against Delta, mu, and other emerging variants of SARS-CoV-2: test negative case-control study. bmj 375:e068848

PubMed  Article  Google Scholar 

Burki TK (2021) Lifting of COVID-19 restrictions in the UK and the Delta variant. Lancet Respir Med 9:e85. https://doi.org/10.1016/S2213-2600(21)00328-3

CAS  Article  PubMed  PubMed Central  Google Scholar 

Campbell F, Archer B, Laurenson-Schafer H et al (2021) Increased transmissibility and global spread of SARS-CoV-2 variants of concern as at June 2021. Euro Surveill 26:2100509

CAS  PubMed Central  Article  Google Scholar 

Chakraborty C, Bhattacharya M, Sharma AR (2021a) Present variants of concern and variants of interest of severe acute respiratory syndrome coronavirus 2: their significant mutations in S-glycoprotein, infectivity, re-infectivity, immune escape and vaccines activity. Rev Med Virol 32:e2270. https://doi.org/10.1002/rmv.2270

CAS  Article  PubMed Central  Google Scholar 

Chakraborty C, Sharma A, Sharma G et al (2020) SARS-CoV-2 causing pneumonia-associated respiratory disorder (COVID-19): diagnostic and proposed therapeutic options. Eur Rev Med Pharmacol Sci 24:4016–4026

CAS  PubMed  Google Scholar 

Chakraborty C, Sharma AR, Bhattacharya M et al (2021b) The current second wave and COVID-19 vaccination status in India. Brain Behav Immun 96:1–4

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chakraborty C, Sharma AR, Bhattacharya M et al (2021c) Evolution, mode of transmission, and mutational landscape of newly emerging SARS-CoV-2 variants. Mbio 12:e01140-e11121

CAS  PubMed Central  Article  Google Scholar 

Chakraborty C, Sharma AR, Bhattacharya M et al (2021d) Asian-origin approved COVID-19 vaccines and current status of COVID-19 vaccination program in Asia: a critical analysis. Vaccines 9:600. https://doi.org/10.3390/vaccines9060600

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chakraborty C, Sharma AR, Bhattacharya M et al (2021e) Ongoing clinical trials of vaccines to fight against COVID-19 pandemic. Immune Netw 21:e5. https://doi.org/10.4110/in.2021.21.e5

Article  PubMed  PubMed Central  Google Scholar 

Chakraborty C, Sharma AR, Bhattacharya M et al (2022a) A paradigm shift in the combination changes of SARS-CoV-2 variants and increased spread of Delta variant (B. 1.617. 2) across the world. Aging Dis 13:927–942

PubMed  PubMed Central  Article  Google Scholar 

Chakraborty C, Sharma AR, Bhattacharya M et al (2022b) Comparative genomics, evolutionary epidemiology, and RBD-hACE2 receptor binding pattern in B. 1.1. 7 (Alpha) and B. 1.617. 2 (Delta) related to their pandemic response in UK and India. Infect Genet Evol 101:105282

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chakraborty C, Bhattacharya M, Sharma AR (2022c) Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance. Curr Opin Pharmacol 62:64–73

CAS  PubMed  Article  Google Scholar 

Chakraborty C, Bhattacharya M, Sharma AR et al (2022d) Recombinant SARS-CoV-2 variants XD, XE, and XF: the emergence of recombinant variants requires an urgent call for research–Correspondence. Int J Surg 102:106670

PubMed  PubMed Central  Article  Google Scholar 

Chakraborty C, Sharma AR, Bhattacharya M et al (2022e) A detailed overview of immune escape, antibody escape, partial vaccine escape of SARS-CoV-2 and their emerging variants with escape mutations. Front Immunol 13:801522

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chemmama IE, Pelea AC, Bhandari YR et al (2012) Structural propensities and entropy effects in peptide helix-coil transitions. Phys Rev E 86:031915

Article  CAS  Google Scholar 

Cherian S, Potdar V, Jadhav S et al (2021) SARS-CoV-2 spike mutations, L452R, E484Q and P681R, in the second wave of COVID-19 in Maharashtra, India. Microorganisms 9:1542

CAS  PubMed  PubMed Central  Article  Google Scholar 

CDC (2021) SARS-CoV-2 variant classifications and definitions. https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-classifications.html (Acession date 12 Nov 2021)

Del Rio C, Malani PN, Omer SB (2021) Confronting the Delta variant of SARS-CoV-2, summer 2021. JAMA 326:1001–1002

PubMed  Article  CAS  Google Scholar 

Dolzhikova I, Gushchin V, Shcheblyakov D et al (2021) One-shot immunization with Sputnik Light (the first component of Sputnik V vaccine) is effective against SARS-CoV-2 Delta variant: efficacy data on the use of the vaccine in civil circulation in Moscow. medRxiv. https://doi.org/10.1101/2021.10.08.21264715

Duong D (2021) Alpha, Beta, Delta, Gamma: what’s important to know about SARS-CoV-2 variants of concern? CMAJ 193:E1059–E1060

CAS  PubMed  PubMed Central  Article  Google Scholar 

Dyer O (2021) Covid-19: unvaccinated face 11 times risk of death from Delta variant. CDC Data Show BMJ 2021(374):n2282

Google Scholar 

Ella R, Reddy S, Blackwelder W et al (2021) Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled, phase 3 trial. Lancet 398:2173–2184

CAS  PubMed  PubMed Central  Article  Google Scholar 

Elbe S, Buckland-Merrett G (2017) Data, disease and diplomacy: GISAID’s innovative contribution to global health. Glob Chall 1:33–46

PubMed  PubMed Central  Article  Google Scholar 

Farinholt T, Doddapaneni H, Qin X et al (2021) Transmission event of SARS-CoV-2 Delta variant reveals multiple vaccine breakthrough infections. BMC Med 19:1–6

Article  CAS  Google Scholar 

Finkelstein MT, Mermelstein AG, Parker Miller E et al (2021) Structural analysis of neutralizing epitopes of the SARS-CoV-2 spike to guide therapy and vaccine design strategies. Viruses 13:134

CAS  PubMed  PubMed Central  Article  Google Scholar 

Gobeil SM, Janowska K, McDowell S et al (2021) Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity. Science 373(6555):eabi622

Article  CAS  Google Scholar 

Gómez CE, Perdiguero B, Esteban M (2021) Emerging SARS-CoV-2 variants and impact in global vaccination programs against SARS-CoV-2/COVID-19. Vaccines 9:243

PubMed  PubMed Central  Article  CAS  Google Scholar 

Hall VG, Ferreira VH, Ku T, Ierullo M et al (2021) Randomized trial of a third dose of mRNA-1273 vaccine in transplant recipients. N Engl J Med 385:1244–1246

PubMed  Article  Google Scholar 

Harder T, Külper-Schiek W, Reda S et al (2021) Effectiveness of COVID-19 vaccines against SARS-CoV-2 infection with the Delta (B. 1.617. 2) variant: second interim results of a living systematic review and meta-analysis, January 1 to August 25 2021. Euro Surveill 14(26):2100920

Google Scholar 

Hatmal MM, Alshaer W, Al-Hatamleh MA et al (2020) Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2. Cells 9:2638

CAS  PubMed Central  Article  Google Scholar 

Kannan SR, Spratt AN, Cohen AR et al (2021) Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses. J Autoimmun 124:102715. https://doi.org/10.1016/j.jaut.2021.102715

CAS  Article  PubMed  PubMed Central  Google Scholar 

Katella K (2021) Things to know about the Delta variant. Yale Medicine News. https://www.yalemedicine.org/news/5-things-to-know-delta-variant-covid (Acessed on 12 Jun 2022)

Katul GG, Mrad A, Bonetti S et al (2020) Global convergence of COVID-19 basic reproduction number and estimation from early-time SIR dynamics. PLoS ONE 15:e0239800

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kumar S, Thambiraja TS, Karuppanan K et al (2022) Omicron and Delta variant of SARS-CoV-2: a comparative computational study of spike protein. J Med Virol 94:1641–1619

CAS 

留言 (0)

沒有登入
gif