Phenylacetyl pepstatin inhibitors of aspartyl proteases from Streptomyces varsoviensis

Umezawa H, Aoyagi T, Morishima H, Matsuzaki M, Hamada M, Takeuchi T. Pepstatin, a new pepsin inhibitor produced by actinomycetes. J Antibiot. 1970;23:259–62.

CAS  Article  Google Scholar 

Morishima H, Takita T, Aoyagi T, Takeuchi T, Umezawa H. The structure of pepstatin. J Antibiot. 1970;23:263–65.

CAS  Article  Google Scholar 

Nakamura K, Morishima H, Takita T, Umezawa H, Iitaka Y. X-ray structure determination of 4-amino-3-hydroxy-6-methylheptanoic acid, an amine component of pepstatin. J Antibiot. 1973;26:255–56.

CAS  Article  Google Scholar 

Marciniszyn J, Hartsuck JA, Tang J. Mode of inhibition of acid proteases by pepstatin. J Biol Chem. 1976;251:7088–94.

CAS  Article  Google Scholar 

Aoyagi T, Yagisawa Y, Kumagai M, Hamada M, Morishima H, Takeuchi T, Umezawa H. Letter: new pepstatins, pepstatins Bu, Pr and Ac produced by Streptomyces. J Antibiot. 1973;26:539–41.

CAS  Article  Google Scholar 

Umezawa H, Miyano T, Murakami T, Takita T, Aoyagi T. Hydroxypepstatin, a new peptatin produced by Streptomyces. J Antibiot. 1973;26:615–17.

CAS  Article  Google Scholar 

Miyano T, Tomiyasu M, Iizuka H, Tomisaka S, Takita T, Aoyagi T, Umezawa H. New pepstatins, pepstatins B and C, and pepstanone A, produced by streptomyces. J Antibiot. 1972;25:489–91.

CAS  Article  Google Scholar 

Omura S, Imamura N, Kawakita K, Mori Y, Yamazaki Y, Masuma R, Takahashi Y, Tanaka H, Huang LY, Woodruff HB. Ahpatinins, new acid protease inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid. J Antibiot. 1986;39:1079–85.

CAS  Article  Google Scholar 

Sun Y, Takada K, Nogi Y, Okada S, Matsunaga S. Lower homologues of Ahpatinin, aspartic protease inhibitors, from a marine Streptomyces sp. J Nat Prod. 2014;77:1749–52.

CAS  Article  Google Scholar 

Fujinaga M, Chernaia MM, Tarasova NI, Mosimann SC, James MN. Crystal structure of human pepsin and its complex with pepstatin. Protein Sci. 1995;4:960–72.

CAS  Article  Google Scholar 

Baldwin ET, Bhat TN, Gulnik S, Hosur MV, Sowder RC 2nd, Cachau RE, Collins J, Silva AM, Erickson JW. Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design. Proc Natl Acad Sci USA. 1993;90:6796–800.

CAS  Article  Google Scholar 

Bhaumik P, Xiao H, Parr CL, Kiso Y, Gustchina A, Yada RY, Wlodawer A. Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum. J Mol Biol. 2009;388:520–40.

CAS  Article  Google Scholar 

Morishima H, Sawa T, Takita T, Aoyagi T, Takeuchi T, Umezawa H. Biosynthetic studies on pepstatin: biosynthesis of (3S, 4S)-4-amino-3-hydroxy-6-methylheptanoic acid moiety. J Antibiot. 1974;27:267–73.

CAS  Article  Google Scholar 

Ju KS, Gao J, Doroghazi JR, Wang KK, Thibodeaux CJ, Li S, Metzger E, Fudala J, Su J, Zhang JK, Lee J, Cioni JP, Evans BS, Hirota R, Labeda DP, van der Donk WA, Metcalf WW. Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes. Proc Natl Acad Sci USA. 2015;112:12175–80.

CAS  Article  Google Scholar 

Fujii K, Ikai Y, Mayumi T, Oka H, Suzuki M, Harada K. A nonempirical method using LC-MS for determination of the absolute configuration of constituent amino acids in a peptide: elucidation of limitations of Marfey’s method and of its separation mechanism. Anal Chem. 1997;69:3346–52.

CAS  Article  Google Scholar 

Blin K, Shaw S, Kloosterman AM, Charlop-Powers Z, van Weezel GP, Medema MH, Weber T. AntiSMASH 6.0: improving cluster detection and comparison capabilities. Nucleic Acids Res. 2021;49:W29–35.

CAS  Article  Google Scholar 

Du L, Sánchez C, Chen M, Edwards DJ, Shen B. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase. Chem Biol. 2000;7:623–42.

CAS  Article  Google Scholar 

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