Beutler, B. Innate immunity: an overview. Mol. Immunol. 40, 845–859 (2004).
CAS PubMed Article Google Scholar
Ferrandon, D., Imler, J. L., Hetru, C. & Hoffmann, J. A. The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nat. Rev. Immunol. 7, 862–874 (2007).
CAS PubMed Article Google Scholar
Kumar, H., Kawai, T. & Akira, S. Pathogen recognition by the innate immune system. Int. Rev. Immunol. 30, 16–34 (2011).
CAS PubMed Article Google Scholar
Ambite, I. et al. Molecular determinants of disease severity in urinary tract infection. Nat. Rev. Urol. 18, 468–486 (2021).
PubMed PubMed Central Article Google Scholar
Nielubowicz, G. R. & Mobley, H. L. T. Host–pathogen interactions in urinary tract infection. Nat. Rev. Urol. 7, 430–441 (2010).
CAS PubMed Article Google Scholar
Klein, R. D. & Hultgren, S. J. Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies. Nat. Rev. Microbiol. 18, 211–226 (2020).
CAS PubMed PubMed Central Article Google Scholar
Lacerda Mariano, L. & Ingersoll, M. A. The immune response to infection in the bladder. Nat. Rev. Urol. 17, 439–458 (2020).
Wu, J. & Abraham, S. N. The roles of T cells in bladder pathologies. Trends Immunol. 42, 248–260 (2021).
CAS PubMed PubMed Central Article Google Scholar
Dinarello, C. A. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol. Rev. 281, 8–27 (2018).
CAS PubMed PubMed Central Article Google Scholar
Fischer, H. et al. Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection. PLoS Pathog. 6, e1001109 (2010).
PubMed PubMed Central Article CAS Google Scholar
Puthia, M. et al. IRF7 inhibition prevents destructive innate immunity — a target for nonantibiotic therapy of bacterial infections. Sci. Transl Med. 8, 336ra359 (2016).
Ambite, I. et al. Molecular basis of acute cystitis reveals susceptibility genes and immunotherapeutic targets. PLoS Pathog. 12, e1005848 (2016).
PubMed PubMed Central Article CAS Google Scholar
Butler, D. S. C. et al. Neuroepithelial control of mucosal inflammation in acute cystitis. Sci. Rep. 8, 11015 (2018).
PubMed PubMed Central Article CAS Google Scholar
Frendéus, B. et al. Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart. J. Exp. Med. 192, 881–890 (2000).
PubMed PubMed Central Article Google Scholar
Frendéus, B., Godaly, G., Hang, L., Karpman, D. & Svanborg, C. Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis. J. Infect. Dis. 183, S56–S60 (2001).
Fischer, H., Yamamoto, M., Akira, S., Beutler, B. & Svanborg, C. Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection. Eur. J. Immunol. 36, 267–277 (2006).
CAS PubMed Article Google Scholar
Sivick, K. E., Schaller, M. A., Smith, S. N. & Mobley, H. L. T. The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract Infection. J. Immunol. 184, 2065 (2010).
CAS PubMed Article Google Scholar
Jaillon, S. et al. The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection. Immunity 40, 621–632 (2014).
CAS PubMed Article Google Scholar
Ching, C. B. et al. Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection. Kidney Int. 93, 1320–1329 (2018).
CAS PubMed PubMed Central Article Google Scholar
Li, B. et al. Inflammation drives renal scarring in experimental pyelonephritis. Am. J. Physiol. Renal Physiol. 312, F43–F53 (2017).
CAS PubMed Article Google Scholar
Symington, J. W. et al. ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1beta-dependent manner. Mucosal Immunol. 8, 1388–1399 (2015).
CAS PubMed PubMed Central Article Google Scholar
Nagamatsu, K. et al. Dysregulation of Escherichia coli alpha-hemolysin expression alters the course of acute and persistent urinary tract infection. Proc. Natl Acad. Sci. USA 112, E871–E880 (2015).
CAS PubMed PubMed Central Article Google Scholar
Schaale, K. et al. Strain- and host species-specific inflammasome activation, IL-1beta release, and cell death in macrophages infected with uropathogenic Escherichia coli. Mucosal Immunol. 9, 124–136 (2016).
CAS PubMed Article Google Scholar
Ingersoll, M. A. & Albert, M. L. From infection to immunotherapy: host immune responses to bacteria at the bladder mucosa. Mucosal Immunol. 6, 1041–1053 (2013).
CAS PubMed Article Google Scholar
Jodal, U., Hanson, A., Holmgren, J. & Kaijser, B. Studies of antibodies and immunoglobulin levels in urine from children with urinary tract infections caused by E. coli. Acta Paediatr. Scand. Suppl. 206 (Suppl. 206), 278 (1970).
Ratner, J. J., Thomas, V. L., Sanford, B. A. & Forland, M. Bacteria-specific antibody in the urine of patients with acute pyelonephritis and cystitis. J. Infect. Dis. 143, 404–412 (1981).
CAS PubMed Article Google Scholar
Svanborg Eden, C., Kulhavy, R., Marild, S., Prince, S. J. & Mestecky, J. Urinary immunoglobulins in healthy individuals and children with acute pyelonephritis. Scand. J. Immunol. 21, 305–313 (1985).
CAS PubMed Article Google Scholar
Jones-Carson, J., Balish, E. & Uehling, D. T. Susceptibility of immunodeficient gene-knockout mice to urinary tract infection. J. Urol. 161, 338–341 (1999).
CAS PubMed Article Google Scholar
Ragnarsdottir, B., Lutay, N., Gronberg-Hernandez, J., Koves, B. & Svanborg, C. Genetics of innate immunity and UTI susceptibility. Nat. Rev. Urol. 8, 449–468 (2011).
Cui, Y. et al. Mucosal-associated invariant T cell-rich congenic mouse strain allows functional evaluation. J. Clin. Invest. 125, 4171–4185 (2015).
PubMed PubMed Central Article Google Scholar
Zychlinsky Scharff, A. et al. Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection. JCI Insight 5, e122998 (2019).
Hagberg, L. et al. Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice. Infect. Immun. 46, 839–844 (1984).
CAS PubMed PubMed Central Article Google Scholar
Hopkins, W. J., James, L. J., Balish, E. & Uehling, D. T. Congenital immunodeficiencies in mice increase susceptibility to urinary tract infection. J. Urol. 149, 922–925 (1993).
CAS PubMed Article Google Scholar
Gur, C. et al. Natural killer cell-mediated host defense against uropathogenic E. coli is counteracted by bacterial hemolysinA-dependent killing of NK cells. Cell Host Microbe 14, 664–674 (2013).
CAS PubMed Article Google Scholar
Mora-Bau, G. et al. Macrophages subvert adaptive immunity to urinary tract infection. PLoS Pathog. 11, e1005044 (2015).
PubMed PubMed Central Article CAS Google Scholar
World Health Organization. Antibiotic resistance (WHO, 2018).
Kunin, C. Detection, Prevention and Management of Urinary Tract Infections (Lea and Febiger, 1987).
Foxman, B. The epidemiology of urinary tract infection. Nat. Rev. Urol. 7, 653 (2010).
Plos, K. et al. Intestinal carriage of P fimbriated Escherichia coli and the susceptibility to urinary tract infection in young children. J. Infect. Dis. 171, 625–631 (1995).
CAS PubMed Article Google Scholar
Kaper, J. B., Nataro, J. P. & Mobley, H. L. Pathogenic Escherichia coli. Nat. Rev. Microbiol. 2, 123–140 (2004).
CAS PubMed Article Google Scholar
Nikaido, H. Antibiotic resistance caused by gram-negative multidrug efflux pumps. Clin. Infect. Dis. 27, S32–S41 (1998).
CAS PubMed Article Google Scholar
Poole, K. Multidrug resistance in Gram-negative bacteria. Curr. Opin. Microbiol. 4, 500–508 (2001).
留言 (0)