Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer

Akudugu J, Serafin A, Bohm L (2015) Further evaluation of uPA and PAI-1 as biomarkers for prostatic diseases. J Cancer Res Clin Oncol 141:627–631

CAS  PubMed  CrossRef  Google Scholar 

Ambrosio MR, Di Serio C, Danza G et al (2016) Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer. Diagn Pathol 11:45

PubMed  PubMed Central  CrossRef  CAS  Google Scholar 

Amith SR, Fliegel L (2013) Regulation of the Na+/H+ exchanger (NHE1) in breast cancer metastasis. Cancer Res 73:1259–1264

CAS  PubMed  CrossRef  Google Scholar 

Amith SR, Fliegel L (2016) The Na+/H+ exchanger in metastasis. Aging 8:1291

PubMed  PubMed Central  CrossRef  Google Scholar 

Amith SR, Fliegel L (2017) Na(+)/H(+) exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics. Semin Cancer Biol 43:35–41

CAS  PubMed  CrossRef  Google Scholar 

Amith SR, Fong S, Baksh S et al (2015a) Na (+)/H (+)exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis? Int J Dev Biol 59:367–377

CAS  PubMed  CrossRef  Google Scholar 

Amith SR, Wilkinson JM, Baksh S et al (2015b) Na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells. Oncotarget 6:1262–1275

PubMed  CrossRef  Google Scholar 

Amith SR, Wilkinson JM, Fliegel L (2016a) KR-33028, a potent inhibitor of the Na+/H+ exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells. Biochem Pharmacol 118:31–39

CAS  PubMed  CrossRef  Google Scholar 

Amith SR, Wilkinson JM, Fliegel L (2016b) Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells. Oncotarget 7:21091–21113

PubMed  PubMed Central  CrossRef  Google Scholar 

Amith SR, Vincent KM, Wilkinson JM et al (2017) Defining the Na(+)/H(+) exchanger NHE1 interactome in triple-negative breast cancer cells. Cell Signal 29:69–77

CAS  PubMed  CrossRef  Google Scholar 

Andersen AP, Moreira JM, Pedersen SF (2014) Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment. Philos Trans R Soc Lond B Biol Sci 369:20130098

PubMed  PubMed Central  CrossRef  Google Scholar 

Andersen AP, Flinck M, Oernbo EK et al (2016) Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment. Mol Cancer 15:45

PubMed  PubMed Central  CrossRef  CAS  Google Scholar 

Andersen AP, Samsoe-Petersen J, Oernbo EK et al (2018) The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms. Int J Cancer 142:2529–2542

CAS  PubMed  CrossRef  Google Scholar 

Angeli A, Trallori E, Ferraroni M et al (2018) Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity. Eur J Med Chem 157:1214–1222

CAS  PubMed  CrossRef  Google Scholar 

Avnet S, Lemma S, Cortini M et al (2016) Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance. Oncotarget 7:63408–63423

PubMed  PubMed Central  CrossRef  Google Scholar 

Azzarito T, Venturi G, Cesolini A et al (2015) Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma. Cancer Lett 356:697–703

CAS  PubMed  CrossRef  Google Scholar 

Boedtkjer E, Bunch L, Pedersen SF (2012) Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy. Curr Pharm Des 18:1345–1371

CAS  PubMed  CrossRef  Google Scholar 

Boedtkjer E, Moreira JM, Mele M et al (2013) Contribution of Na+, HCO3(−)-cotransport to cellular pH control in human breast cancer: a role for the breast cancer susceptibility locus NBCn1 (SLC4A7). Int J Cancer 132:1288–1299

CAS  PubMed  CrossRef  Google Scholar 

Bohm L, Serafin A, Akudugu J et al (2013) uPA/PAI-1 ratios distinguish benign prostatic hyperplasia and prostate cancer. J Cancer Res Clin Oncol 139:1221–1228

PubMed  CrossRef  CAS  Google Scholar 

Brant SR, Yun CHC, Donowitz M et al (1995) Cloning, tissue distribution, and functional analysis of the human Na+/H+ exchanger isoform, NHE3. Am J Physiol 269:C198–C206

CAS  PubMed  CrossRef  Google Scholar 

Buckley BJ, Aboelela A, Minaei E et al (2018) 6-substituted hexamethylene amiloride (HMA) derivatives as potent and selective inhibitors of the human urokinase plasminogen activator for use in cancer. J Med Chem 61:8299–8320

CAS  PubMed  PubMed Central  CrossRef  Google Scholar 

Busco G, Cardone RA, Greco MR et al (2010) NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space. FASEB J 24:3903–3915

CAS  PubMed  CrossRef  Google Scholar 

Canitano A, Iessi E, Spugnini EP et al (2016) Proton pump inhibitors induce a caspase-independent antitumor effect against human multiple myeloma. Cancer Lett 376:278–283

CAS  PubMed  CrossRef  Google Scholar 

Capecci J, Forgac M (2013) The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells. J Biol Chem 288:32731–32741

CAS  PubMed  PubMed Central  CrossRef  Google Scholar 

Cardone RA, Casavola V, Reshkin SJ (2005) The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis. Nat Rev Cancer 5:786–795

CAS  PubMed  CrossRef  Google Scholar 

Chambard JC, Pouyssegur J (1986) Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0----G1 transition of fibroblasts. Exp Cell Res 164:282–294

CAS  PubMed  CrossRef  Google Scholar 

Chatterjee S, Schmidt S, Pouli S et al (2014) Membrane androgen receptor sensitive Na+/H+ exchanger activity in prostate cancer cells. FEBS Lett 588:1571–1579

CAS  PubMed  CrossRef  Google Scholar 

Chiche J, Ilc K, Laferriere J et al (2009) Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 69:358–368

CAS  PubMed  CrossRef  Google Scholar 

Chiche J, Le Fur Y, Vilmen C et al (2012) In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH. Int J Cancer 130:1511–1520

CAS  PubMed  CrossRef  Google Scholar 

Choi SY, Xue H, Wu R et al (2016) The MCT4 gene: a novel, potential target for therapy of advanced prostate cancer. Clin Cancer Res 22:2721–2733

CAS  PubMed  CrossRef  Google Scholar 

Cordat E, Casey JR (2009) Bicarbonate transport in cell physiology and disease. Biochem J 417:423–439

CAS  PubMed  CrossRef  Google Scholar 

Cordat E, Reithmeier RA (2014) Structure, function, and trafficking of SLC4 and SLC26 anion transporters. Curr Top Membr 73:1–67

CAS  PubMed  CrossRef  Google Scholar 

Cotter K, Capecci J, Sennoune S et al (2015) Activity of plasma membrane V-ATPases is critical for the invasion of MDA-MB231 breast cancer cells. J Biol Chem 290:3680–3692

CAS  PubMed  CrossRef  Google Scholar 

Cotter K, Liberman R, Sun-Wada G et al (2016) The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer. Oncotarget 7:46142–46157

PubMed  PubMed Central  CrossRef  Google Scholar 

De Milito A, Fais S (2005) Proton pump inhibitors may reduce tumour resistance. Expert Opin Pharmacother 6:1049–1054

PubMed  CrossRef  Google Scholar 

De Milito A, Canese R, Marino ML et al (2010) pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity. Int J Cancer 127:207–219

PubMed  CrossRef  CAS  Google Scholar 

Debreova M, Csaderova L, Burikova M et al (2019) CAIX regulates invadopodia formation through both a pH-dependent mechanism and interplay with actin regulatory proteins. Int J Mol Sci 20:2745

CAS  PubMed Central  CrossRef  Google Scholar 

Dhup S, Dadhich RK, Porporato PE et al (2012) Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. Curr Pharm Des 18:1319–1330

CAS  PubMed  CrossRef  Google Scholar 

Dubois L, Peeters SG, Van Kuijk SJ et al (2013) Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs. Radiother Oncol 108:523–528

CAS  PubMed  CrossRef  Google Scholar 

Dykes SS, Gao C, Songock WK et al (2017a) Zinc finger E-box binding homeobox-1 (Zeb1) drives anterograde lysosome trafficking and tumor cell invasion via upregulation of Na+/H+ exchanger-1 (NHE1). Mol Carcinog 56:722–734

CAS 

留言 (0)

沒有登入
gif