Differential routing and disposition of the long-chain saturated fatty acid palmitate in rodent vs human beta-cells

Oh YS, Bae GD, Baek DJ, Park EY, Jun HS. Fatty acid-induced lipotoxicity in pancreatic beta cells during development of type 2 diabetes. Front Endocrinol (Lausanne). 2018;9:384.

Article  Google Scholar 

Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes and its complications. Nat Rev Endocrinol. 2018;14:88–98.

Article  Google Scholar 

Welters HJ, Tadayyon M, Scarpello JH, Smith SA, Morgan NG. Monounsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett. 2004;560:103–8.

CAS  Article  Google Scholar 

Weir GC. Glucolipotoxicity, β-cells, and diabetes: The emperor has no clothes. Diabetes. 2019;69:273–8.

Article  Google Scholar 

Stevens S, Hollingsworth KG, Small PK, Woodcock SA, Pucci A, Aribisala B, et al. Weight loss decreases excess pancreatic triacylglycerol specifically in type 2 diabetes. Diabetes Care. 2016;39:158–65.

Article  Google Scholar 

Huber AH, Kleinfeld AM. Unbound free fatty acid profiles in human plasma and the unexpected absence of unbound palmitoleate. J Lipid Res. 2017;58:578–85.

CAS  Article  Google Scholar 

Sansone A, Tolika E, Louka M, Sunda V, Deplano S, Melchiorre M, et al. Hexadecenoic fatty acid isomers in human blood lipids and the relevance for the interpretation of lipodomic profiles. PLoS ONE. 2016;11:e0152378.

Article  Google Scholar 

Diakogiannaki E, Welter HJ, Morgan NG. Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J Endocrinol. 2008;197:553–63.

CAS  Article  Google Scholar 

Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes. 2003;52:726–33.

CAS  Article  Google Scholar 

Cunha DJ, Hekerman P, Ladriere L, Bazarra-Castro A, Ortis F, Wakeham MC, et al. Initiation and execution of lipotoxic ER stress in pancreatic β-cells. J Cell Sci. 2008;121:2308–18.

CAS  Article  Google Scholar 

Molina AJ, Wikstrom J,D, Stiles L, Las G, Mohamed H, Elorza A, et al. Mitochondrial networking protects beta cells from nutrient-induced apoptosis. Diabetes. 2009;58:2303–15.

CAS  Article  Google Scholar 

Dhayal S, Zummo FP, Anderson MW, Thomas P, Welters HJ, Arden C, et al. Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells. J Mol Endocrinol. 2019;63:285–96.

CAS  Article  Google Scholar 

Vernier S, Chiu A, Schober J, Weber T, Nguyen P, Luer M, et al. β-cell metabolic alterations under chronic nutrient overload in rat and human islets. Islets. 2012;4:379–92.

Article  Google Scholar 

Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A, et al. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology. 2006;147:3398–407.

CAS  Article  Google Scholar 

Zhu Y, Zhang X, Zhang L, Zhang M, Li L, Luo D, et al. Perilipin 5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells. Nutr Metab (Lond). 2019;16:50.

Article  Google Scholar 

Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G. Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic β-cells via activation of mTORC1. PLoS One. 2009;4:e4954.

Article  Google Scholar 

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, et al. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia. 2007;50:2486–94.

CAS  Article  Google Scholar 

Graciano MF, Valle MM, Kowluru A, Curi R, Carpinelli AR. Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets. Islets. 2011;3:213–23.

Article  Google Scholar 

Plötz T, von Hanstein AS, Krummel B, Laporte A, Mehmeti I, Lenzen S. Structure-toxicity relationships of saturated and unsaturated free fatty acids for elucidating the lipotoxic effects in human EndoC-βH1 beta-cells. Biochim Biophys Acta Mol Basis Dis. 2019;1865:165525.

Article  Google Scholar 

Ravassard P, Hazhouz Y, Pechberty S, Bricout-Neveu E, Armanet M, Czernichow P, et al. A genetically human pancreatic β-cell line exhibiting glucose-inducible insulin secretion. J Clin Invest. 2011;121:3589–97.

CAS  Article  Google Scholar 

Oshima M, Pechberty S, Bellini L, Gopel SO, Campana M, Rouch C, et al. Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity. Diabetologia. 2019;63:395–409.

Article  Google Scholar 

Krizhanovskii C, Kristinsson H, Elksnis A, Wang X, Gavali H, Bergsten P, et al. EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium. Islets. 2017;9:e1296995.

Article  Google Scholar 

Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Ringgaard AK, Ingvorsen C, et al. The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates. Mol Metab. 2018;8:144–57.

CAS  Article  Google Scholar 

Carta G, Murru E, Banni S, Manca C. Palmitic acid: physiological role, metabolism and nutritional implications. Front Physiol. 2017;8:902.

Article  Google Scholar 

Asfari M, Janjic D, Meda P, Halban PA, Wollheim CB. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology. 1992;130:167–78.

CAS  Article  Google Scholar 

Hohmeier HE, Mulder H, Chen G, Henkel-Rieger R, Prentki M, Newgard CB. Isolation of INS-1 derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes. 2000;49:424–30.

CAS  Article  Google Scholar 

Costello JL, Castro IG, Hacker C, Schrader C, Metz J, Zeuschner D, et al. ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. J Cell Biol. 2017;216:2.

Article  Google Scholar 

Peng G, Li L, Liu Y, Pu J, Zhang S, Yu J, et al. Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and insulin resistance in skeletal muscle. Endocrinology. 2011;152:2206–18.

CAS  Article  Google Scholar 

Oleson BJ, McGraw JA, Broniowska K, Bushkofsky J, Davis D. Distinct differences in the responses of the human pancreatic β-cell line EndoC-BH1 and human islets to proinflammatory cytokines. Am J Physiol Regul Integr Comp Physiol. 2015;309:R525–R534.

CAS  Article  Google Scholar 

Plötz T, Hartmann M, Lenzen S, Elsner M. The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells. Nutr Metab (Lond). 2016;13:16.

Article  Google Scholar 

Tong X, Stein R. Lipid droplets protect human β-cells from lipotoxicity-induced stress and cell identity changes. Diabetes. 2021;70:11.

Article  Google Scholar 

Borg J, Klint C, Wierup N, Strom K, Larsson S, Sundler F, et al. Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the β-cell line INS-1. Endocrinology 2009;150:3049–57.

CAS  Article  Google Scholar 

Liu J, Huang Y, Li T, Jiang Z, Zeng L, Hu Z. The role of the Golgi apparatus in disease. Int J Mol Med. 2021;47:4.

Google Scholar 

Hicks SW, Machamer CE. Golgi structure in stress sensing and apoptosis. Biochim Biophys Acta. 2005;1744:406–414.

CAS  Article  Google Scholar 

Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, et al. A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens. Nat Cell Biol. 2013;15:12.

Article  Google Scholar 

Tito S, Hervas J,H, van Vliet A,R, Tooze SA. The Golgi as an assembly line to the autophagosome. Trends Biochem Sci. 2020;45:6.

Article  Google Scholar 

Liu L, Choudhary C, Toulmay A, Prinz WA. An inducible ER-Golgi tether facilitates ceramide transport to alleviate lipotoxicity. J Cell Biol. 2016;216:1.

Google Scholar 

Veret J, Bellini L, Giussani P, Ng C, Magnan C, Stunff HL. Roles of sphingolipid metabolism in pancreatic β cell dysfunction induced lipotoxicity. J Clin Med. 2014;3:2.

Article  Google Scholar 

留言 (0)

沒有登入
gif