Document Type : Review Paper

Authors

1 Pharmacognosy department, Pharmacy faculty, Tabriz university of medical sciences, TABRIZ, IRAN

2 Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Associate Professor of pharmacognosy Faculty of pharmacy Tabriz University of Medical Sciences Tabriz, Iran

10.22037/ijpr.2021.115918.15592

Abstract

The Symphytum genus has been mainly used in traditional medicine, containing its anti-inflammatory activity. Symphytum spp.’s active components, such as allantoin, polyphenols, flavonoids, and alkaloids, can act on several intention in the signaling pathway, constrain pro-inflammatory enzymes, reduced the construction of inflammatory chemokine’s and cytokines, and decrease oxidative stress, which afterward suppresses inflammation procedures. Preclinical and clinical trials have reported the prevailing anti-inflammatory effect of several Symphytum species. This review presents an overview of the anti-inflammatory activities of different products and bioactive constituents in this genus. The papers with the English language gathered from 2000 to 2021.This review may provide a scientific base for establishing innovative and alternative techniques for isolating a single individual from this genus to attenuate inflammatory disorders. The Symphytum genus is waiting for researchers for developing safe and effective anti-inflammatory agents for additional investigation other different mechanisms of action.

Keywords