1Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy

2IRCCS Neuromed, Pozzilli, (IS), Italy

3National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy

4Multiple Sclerosis Clinical and Research Unit, Department of Systems Medicine, Tor Vergata University, Rome, Italy

5S. Filippo Neri Hospital, Rome, Italy

6Department of Neurosciences, Mental Health, and Sensory Organs (NESMOS), Sapienza, University of Rome, Rome, Italy

A Conte Department of Human Neuroscience, Sapienza University of Rome, Viale dell’Università, 30, 00185 Rome, Italy. IRCCS Neuromed, Pozzilli, Italy [email protected]

*These authors contributed equally to the study.