aSchool of Biomedical Sciences, Faculty of Medicine, University of Queensland, Queensland, Australia

bBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

*Dr. Felicity Y. Han and Dr. David A. Brockman are considered as co-first author.

Received 17 September 2021 Accepted as revised 2 November 2021

Correspondence to Maree Therese Smith, PhD, Centre for Integrated Preclinical Drug Development, School of Biomedical Sciences, The University of Queensland, St Lucia Campus, Brisbane, QLD, 4072, Australia, Tel: +61 7 33652554; fax: +61 7 33467391; e-mail: [email protected], Twitter: @MareeSmith19