The PKCγ neurons in anterior cingulate cortex contribute to the development of neuropathic allodynia and pain-related emotion

1. Hughes, AS, Averill, S, King, VR, et al. Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat. Neuroscience 2008; 153: 507–517. DOI: 10.1016/j.neuroscience.2008.01.082.
Google Scholar | Crossref | Medline2. Wang, Q, Zhang, X, He, X, et al. Synaptic dynamics of the feed-forward inhibitory circuitry gating mechanical allodynia in mice. Anesthesiology 2020; 132: 1212–1228. DOI: 10.1097/ALN.0000000000003194.
Google Scholar | Crossref | Medline3. Petitjean, H, Pawlowski, SA, Fraine, SL, et al. Dorsal horn parvalbumin neurons are gate-keepers of touch-evoked pain after nerve injury. Cel Reports 2015; 13: 1246–1257. DOI: 10.1016/j.celrep.2015.09.080.
Google Scholar | Crossref | Medline | ISI4. Alba-Delgado, C, El Khoueiry, C, Peirs, C, et al. Subpopulations of PKCγ interneurons within the medullary dorsal horn revealed by electrophysiologic and morphologic approach. Pain 2015; 156: 1714–1728. DOI: 10.1097/j.pain.0000000000000221.
Google Scholar | Crossref | Medline5. Zou, W, Song, Z, Guo, Q, et al. Intrathecal lentiviral-mediated RNA interference targeting PKCγ attenuates chronic constriction injury-induced neuropathic pain in rats. Hum Gene Therapy 2011; 22: 465–475. DOI: 10.1089/hum.2010.207.
Google Scholar | Crossref | Medline6. Di Cesare Mannelli, L, Ghelardini, C, Toscano, A., et al. The neuropathy-protective agent acetyl-l-carnitine activates protein kinase C-γ and MAPKs in a rat model of neuropathic pain. Neuroscience 2010; 165: 1345–1352. DOI: 10.1016/j.neuroscience.2009.11.021.
Google Scholar | Crossref | Medline7. Cheng, HT, Suzuki, M, Hegarty, DM, et al. Inflammatory pain-induced signaling events following a conditional deletion of the N-methyl-D-aspartate receptor in spinal cord dorsal horn. Neuroscience 2008; 155: 948–958. DOI: 10.1016/j.neuroscience.2008.06.024.
Google Scholar | Crossref | Medline8. Pham-Dang, N, Descheemaeker, A, Dallel, R, et al. Activation of medullary dorsal horn γ isoform of protein kinase C interneurons is essential to the development of both static and dynamic facial mechanical allodynia. Eur J Neurosci 2016; 43: 802–810. DOI: 10.1111/ejn.13165.
Google Scholar | Crossref | Medline9. Saito, N, Kikkawa, U, Nishizuka, Y, et al. Distribution of protein kinase C-like immunoreactive neurons in rat brain. J Neurosci 1988; 8: 369–382. DOI: 1988/02/01.
Google Scholar | Crossref | Medline10. Huang, F, Yoshida, Y, Nakabayashi, H, et al. Immunocytochemical localization of protein kinase C isozymes in rat brain. J Neurosci 1988; 8: 4734–4744. DOI: 1988/12/01.
Google Scholar | Crossref | Medline | ISI11. Adkins, JM, Lynch, JF, Hagerdorn, P, et al. Anterior cingulate cortex and dorsal hippocampal glutamate receptors mediate generalized fear in female rats. Psychoneuroendocrinology 2019; 107: 109–118. DOI: 10.1016/j.psyneuen.2019.05.009.
Google Scholar | Crossref | Medline12. Barthas, F, Sellmeijer, J, Hugel, S, et al. The anterior cingulate cortex is a critical hub for pain-induced depression. Biol Psychiatry 2015; 77: 236–245. DOI: 10.1016/j.biopsych.2014.08.004.
Google Scholar | Crossref | Medline | ISI13. LaGraize, SC, Fuchs, PN. GABAA but not GABAB receptors in the rostral anterior cingulate cortex selectively modulate pain-induced escape/avoidance behavior. Exp Neurology 2007; 204: 182–194. DOI: 10.1016/j.expneurol.2006.10.007.
Google Scholar | Crossref | Medline14. Paus, T . Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nat Reviews Neurosci 2001; 2: 417–424. DOI: 10.1038/35077500.
Google Scholar | Crossref | Medline | ISI15. Hadland, KA, Rushworth, MFS, Gaffan, D, et al. The anterior cingulate and reward-guided selection of actions. J Neurophysiology 2003; 89: 1161–1164. DOI: 10.1152/jn.00634.2002.
Google Scholar | Crossref | Medline | ISI16. Walton, ME, Devlin, JT, Rushworth, MFS. Interactions between decision making and performance monitoring within prefrontal cortex. Nat Neuroscience 2004; 7: 1259–1265. DOI: 10.1038/nn1339.
Google Scholar | Crossref | Medline17. Yin, J-B, Liang, S-H, Li, F, et al. dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors. J Clin Invest 2020; 130: 6555–6570. DOI: 10.1172/JCI127607.
Google Scholar | Crossref | Medline18. Gao, S-H, Shen, L-L, Wen, H-Z, et al. The projections from the anterior cingulate cortex to the nucleus accumbens and ventral tegmental area contribute to neuropathic pain-evoked aversion in rats. Neurobiol Disease 2020; 140: 104862. DOI: 10.1016/j.nbd.2020.104862.
Google Scholar | Crossref | Medline19. Gutzeit, A, Meier, D, Froehlich, JM, et al. Differential NMR spectroscopy reactions of anterior/posterior and right/left insular subdivisions due to acute dental pain. Eur Radiology 2013; 23: 450–460. DOI: 10.1007/s00330-012-2621-0.
Google Scholar | Crossref | Medline20. Mullins, P, Rowland, L, Jung, R, et al. A novel technique to study the brain's response to pain: proton magnetic resonance spectroscopy. NeuroImage 2005; 26: 642–646. DOI: 10.1016/j.neuroimage.2005.02.001.
Google Scholar | Crossref | Medline | ISI21. Bushnell, MC, Čeko, M, Low, LA. Cognitive and emotional control of pain and its disruption in chronic pain. Nat Reviews Neurosci 2013; 14: 502–511. DOI: 10.1038/nrn3516.
Google Scholar | Crossref | Medline | ISI22. Costigan, M, Scholz, J, Woolf, CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Review Neuroscience 2009; 32: 1–32. DOI: 10.1146/annurev.neuro.051508.135531.
Google Scholar | Crossref | Medline | ISI23. Saab, CY . Pain-related changes in the brain: diagnostic and therapeutic potentials. Trends Neurosciences 2012; 35: 629–637. DOI: 10.1016/j.tins.2012.06.002.
Google Scholar | Crossref | Medline | ISI24. Gussew, A, Rzanny, R, Erdtel, M, et al. Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation. NeuroImage 2010; 49: 1895–1902. DOI: 10.1016/j.neuroimage.2009.09.007.
Google Scholar | Crossref | Medline25. Zunhammer, M, Schweizer, LM, Witte, V, et al. Combined glutamate and glutamine levels in pain-processing brain regions are associated with individual pain sensitivity. Pain 2016; 157: 2248–2256. DOI: 10.1097/j.pain.0000000000000634.
Google Scholar | Crossref | Medline26. Cleve, M, Gussew, A, Reichenbach, JR. In vivo detection of acute pain-induced changes of GABA+ and Glx in the human brain by using functional 1H MEGA-PRESS MR spectroscopy. NeuroImage 2015; 105: 67–75. DOI: 10.1016/j.neuroimage.2014.10.042.
Google Scholar | Crossref | Medline27. Ko, HG, Park, DI, Lee, JH, et al. Proteomic analysis of synaptic protein turnover in the anterior cingulate cortex after nerve injury. Mol Brain 2020; 13: 19. DOI: 19. 2020/02/1410.1186/s13041-020-0564-y.
Google Scholar | Crossref | Medline28. Bennett, GJ, Chung, JM, Honore, M, et al. Models of neuropathic pain in the rat. Curr Protocols Neuroscience 2003; 22, Chapter 9. DOI: 10.1002/0471142301.ns0914s22. Unit 9 14.
Google Scholar | Crossref29. Duan, B, Cheng, L, Bourane, S, et al. Identification of spinal circuits transmitting and gating mechanical pain. Cell 2014; 159: 1417–1432. DOI: 10.1016/j.cell.2014.11.003.
Google Scholar | Crossref | Medline | ISI30. Zang, K-K, Xiao, X, Chen, L-Q, et al. Distinct function of estrogen receptors in the rodent anterior cingulate cortex in pain-related aversion. Anesthesiology 2020; 133: 165–184. DOI: 10.1097/ALN.0000000000003324.
Google Scholar | Crossref | Medline31. Fan, Y, Liang, X, Wang, R, et al. Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats. Brain Research Bulletin 2017; 135: 105–112. DOI: 10.1016/j.brainresbull.2017.10.005.
Google Scholar | Crossref | Medline32. Chen, C, Kano, M, Abeliovich, A, et al. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCγ mutant mice. Cell 1995; 83: 1233–1242.
Google Scholar | Crossref | Medline33. Zerbi, V, Floriou-Servou, A, Markicevic, M, et al. Rapid reconfiguration of the functional connectome after chemogenetic locus coeruleus activation. Neuron 2019; 103: 702–718. DOI: e705. 2019/06/2310.1016/j.neuron.2019.05.034.
Google Scholar | Crossref | Medline34. Juarez-Salinas, DL, Braz, JM, Etlin, A, et al. GABAergic cell transplants in the anterior cingulate cortex reduce neuropathic pain aversiveness. Brain 2019; 142: 2655–2669. DOI: 10.1093/brain/awz203.
Google Scholar | Crossref | Medline35. Alba-Delgado, C, Mountadem, S, Mermet-Joret, N, et al. 5-HT2A receptor-induced morphological reorganization of PKCγ-expressing interneurons gates inflammatory mechanical allodynia In rat. J Neurosci 2018; 38: 10489–10504. DOI: 10.1523/JNEUROSCI.1294-18.2018.
Google Scholar | Crossref | Medline36. Elina, KC, Moon, HC, Islam, J, et al. The effect of optogenetic inhibition of the anterior cingulate cortex in neuropathic pain following sciatic nerve injury. J Mol Neurosci 2021; 71: 638–650. DOI: 10.1007/s12031-020-01685-7.
Google Scholar | Crossref | Medline37. Ren, L-Y, Lu, Z-M, Liu, M-G, et al. Distinct roles of the anterior cingulate cortex in spinal and supraspinal bee venom-induced pain behaviors. Neuroscience 2008; 153: 268–278. DOI: 10.1016/j.neuroscience.2008.01.067.
Google Scholar | Crossref | Medline38. Xiao-Die, X, Xiao-Hong, W, Cheng-Feng, H, et al. Increased NRSF/REST in anterior cingulate cortex contributes to diabetes-related neuropathic pain. Biochem Biophysical Research Communications 2020; 527: 785–790. DOI: 10.1016/j.bbrc.2020.04.106.
Google Scholar | Crossref | Medline39. Li, Y-D, Ge, J, Luo, Y-J, et al. High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice. Pain 2020; 161: 288–299. DOI: 10.1097/j.pain.0000000000001725.
Google Scholar | Crossref | Medline40. Shumilla, JA, Liron, T, Mochly-Rosen, D, et al. Ethanol Withdrawal-Associated Allodynia and Hyperalgesia: Age-Dependent Regulation by Protein Kinase Cϵ and γ Ιsozymes. The J Pain 2005; 6: 535–549. DOI: 10.1016/j.jpain.2005.03.005.
Google Scholar | Crossref | Medline41. Malmberg, AB, Chen, C, Tonegawa, S, et al. Preserved acute pain and reduced neuropathic pain in mice lacking PKCγ. Science 1997; 278: 279–283.
Google Scholar | Crossref | Medline | ISI

留言 (0)

沒有登入
gif