Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

1. Heidenreich, P, Trogdon, J, Khavjou, O, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123(8):933–944.
Google Scholar | Crossref | Medline | ISI2. Fisher, M . Cardiometabolic disease: the new challenge? Pract Diab Int. 2006;23(3):95–97.
Google Scholar | Crossref3. Brunzell, JD, Davidson, M, Furberg, CD, et al. Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care. 2008;31(4):811–822.
Google Scholar | Crossref | Medline | ISI4. Kamali, SH, Khalaj, AR, Hasani-Ranjbar, S, et al. Efficacy of “Itrifal Saghir”, a combination of three medicinal plants in the treatment of obesity; a randomized controlled trial. Daru. 2012;20(1):33. doi:10.1186/2008-2231-20-33
Google Scholar | Crossref | Medline5. Peterson, CT, Denniston, K, Chopra, D. Therapeutic uses of triphala in Ayurvedic medicine. J Altern Complement Med. 2017;23(8):607–614.
Google Scholar | Crossref | Medline6. Biradar, YS, Jagatap, S, Khandelwal, KR, Singhania, SS. Exploring of antimicrobial activity of Triphala Mashi—an Ayurvedic formulation. Evid Based Complement Alternat Med. 2008;5(1):107–113.
Google Scholar | Crossref | Medline7. Manoraj, A, Thevanesam, V, Bandara, BMR, Ekanayake, A, Liyanapathirana, V. Synergistic activity between Triphala and selected antibiotics against drug resistant clinical isolates. BMC Complement Altern Med. 2019;19(1):199.
Google Scholar | Crossref | Medline8. Naik, GH, Priyadarsini, KI, Bhagirathi, RG, et al. In vitro antioxidant studies and free radical reactions of triphala, an ayurvedic formulation and its constituents. Phytother Res. 2005;19(7):582–586.
Google Scholar | Crossref | Medline9. Kalaiselvan, S, Rasool, MK. The anti-inflammatory effect of triphala in arthritic-induced rats. Pharm Biol. 2015;53(1):51–60.
Google Scholar | Crossref | Medline10. Baskaran, UL, Martin, SJ, Mahaboobkhan, R, Prince, SE. Protective role of triphala, an Indian traditional herbal formulation, against the nephrotoxic effects of bromobenzene in Wistar albino rats. J Integr Med. 2015;13(2):115–121.
Google Scholar | Crossref | Medline11. Prasad, S, Srivastava, SK. Oxidative stress and cancer: chemopreventive and therapeutic role of triphala. Antioxidants (Basel). 2020;9(1):72.
Google Scholar | Crossref12. Jagetia, GC, Baliga, MS, Malagi, KJ, Kamath, MS. The evaluation of the radioprotective effect of triphala (an ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation. Phytomedicine. 2002;9(2):99–108.
Google Scholar | Crossref | Medline13. Sandhya, T, Lathika, KM, Pandey, BN, et al. Protection against radiation oxidative damage in mice by triphala. Mutat Res. 2006;609(1):17–25.
Google Scholar | Crossref | Medline14. Belapurkar, P, Goyal, P, Tiwari-Barua, P. Immunomodulatory effects of triphala and its individual constituents: a review. Indian J Pharm Sci. 2014;76(6):467–475.
Google Scholar | Medline15. Baliga, MS, Meera, S, Mathai, B, Rai, MP, Pawar, V, Palatty, PL. Scientific validation of the ethnomedicinal properties of the Ayurvedic drug triphala: a review. Chin J Integr Med. 2012;18(12):946–954.
Google Scholar | Crossref | Medline16. Ekanayaka, R, Rupasinha, A, Sooriyarachchi, M, Goonaratna, C. The effect of thriphala, a herbal Ayurveda formulation, on serum lipids, in patients on a maintenance dose of atorvastatin for hyperlipidaemia: a randomized controlled trial. Ceylon Med. J. 2017;62(3):128–140.
Google Scholar | Crossref | Medline17. Wichiansaen, P . The effectiveness of triphala (Thai traditional medicine) on lowering blood lipid level in hyperlipidemic subject. Published 2014. Accessed March 1, 2020. http://www.mfu.ac.th/school/anti-aging/File_PDF/Research_PDF55/Proceeding_6.pdf
Google Scholar18. Rajan, SS, Antony, S. Hypoglycemic effect of triphala on selected non insulin dependent diabetes mellitus subjects. Ancient Sci Life. 2008;27(3):45–49.
Google Scholar | Medline19. Prommart, P . Effect of triphala on decreasing the level of blood glucose and hemoglobin A1C in prediabetes subjects [dissertation]. Mae Fah Luang University; 2014.
Google Scholar20. Singh, N, Mahajan, S, Subramani, SK, Yadav, D, Singh, L. Triphala improves glucose homeostasis by alleviating atherogenic lipids and oxidative stress in human type 2 diabetes mellitus. IJAM. 2015;6(3):212–219.
Google Scholar21. Gupte, P, Harke, S, Deo, V, Bhushan, SB, Mahajan, M, Bhalerao, S. A clinical study to evaluate the efficacy of herbal formulation for obesity (HFO-02) in overweight individuals. J Ayurveda Integr Med. 2020;11(2):159–162. doi:10.1016/j.jaim.2019.05.003. Epub ahead of print.
Google Scholar | Crossref | Medline22. Kaewtong, A, Sugraroek, P. Effects of thiphala herbal formula in obesity stage 1 subjects at Maharaj Nakhonsithammarat Hospital. Suthiparithat. 2018;32(103):119–130.
Google Scholar23. Higgins, JPT, Green, S. Cochrane Handbook for Systematic Reviews of Interventions Version 6.2, 2021. Published 2021. Accessed March 15, 2021. https://training.cochrane.org/handbook/current
Google Scholar24. Moher, D, Liberati, A, Tetzlaff, J, Altman, DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–269
Google Scholar | Crossref | Medline | ISI25. Jadad, AR, Moore, RA, Carroll, D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1–12.
Google Scholar | Crossref | Medline26. Higgins, JPT, Savovic, J, Page, MJ, Sterne, JAC. Revised Cochrane Risk of Bias Tool for Randomized Trials (RoB 2.s0). Published 2011. Updated 2016. Accessed November 15, 2019. https://methods.cochrane.org/bias/resources/rob-2-revised-cochrane-risk-bias-tool-randomized-trials
Google Scholar27. Paranjpe, P, Patki, P, Patwardhan, B. Ayurvedic treatment of obesity: a randomised double-blind, placebo-controlled clinical trial. J Ethnopharmacol. 1990;29(1):1–11.
Google Scholar | Crossref | Medline28. Nohr, LA, Rasmussen, LB, Straand, J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther Med. 2009;17(1):16–22.
Google Scholar | Crossref | Medline | ISI29. Chaudhary, V, Rohila, R. Evaluation of an Ayurvedic formulation in the management of essential hypertension in elderly patients. Int J Ayur Pharma Research. 2015;3(1):72–77.
Google Scholar30. Pai, S, Shivappa, CB, Surendra, A. Anti-obesity and anti-hyperlipidemic activity of processed honey—a randomised, open labeled, controlled clinical study. J Res Tradit Med. 2018;4(2):40–48.
Google Scholar | Crossref31. Chaitralakshmi, KN, Basarigidad, JP. A comparative clinical study to evaluate the effect of Haridradi Gana Churna and Triphala Churna Udvartana in Sthoulya (obesity). IJAPR. 2019;7(2):40–45.
Google Scholar32. Salunke, M, Banjare, J, Bhalerao, S. Effect of selected herbal formulations on anthropometry and body composition in overweight and obese individuals: randomized, double blind, placebo-controlled study. J Herb Med. 2019:17:100298. Article 100298. doi:10.1016/j.hermed.2019.100298
Google Scholar | Crossref33. Conget, I, Giménez, M. Glucose control and cardiovascular disease. Diabetes Care. 2009;32(suppl 2):S334–S336.
Google Scholar | Crossref | Medline34. Wakabayashi, I, Daimon, T. A strong association between lipid accumulation product and diabetes mellitus in Japanese women and men. J Atheroscler Thromb. 2014;21(3):282–288.
Google Scholar | Crossref | Medline35. Poirier, P, Giles, TD, Bray, GA, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2006;113(6):898–918.
Google Scholar | Crossref | Medline | ISI36. Sampson, UK, Fazio, S, Linton, MF. Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: the evidence, etiology, and therapeutic challenges. Curr Atheroscler Rep. 2012;14(1):1–10.
Google Scholar | Crossref | Medline | ISI37. Kirby, RJ, Howles, PN, Hui, DY. Rate of gastric emptying influences dietary cholesterol absorption efficiency in selected inbred strains of mice. J Lipid Res. 2004;45(1):89–98.
Google Scholar | Crossref | Medline38. Saravanan, S, Srikumar, R, Manikandan, S, Parthasarathy, N, Sheela, DR. Hypolipidemic effect of triphala in experimentally induced hypercholesteremic rats. Yakugaku Zasshi. 2007;127(2):385–388.
Google Scholar | Crossref | Medline39. Poopiewkhum, T, Phanngam, P, Jataboon, S. Anti-HMG CoA reductase activity and TLC fingerprinting of triphala extract [dissertation]. Mahasarakham University; 2014.
Google Scholar40. Banjare, J, Raina, P, Mansara, P, Ghanekar, RK, Bhalerao, S. Triphala, regulates adipogenesis through modulation of expression of adipogenic genes in 3T3-L1 cell line. Pharmacogn Mag. 2018;13(suppl 4):S834–S839.
Google Scholar | Medline41. Nelson, RH . Hyperlipidemia as a risk factor for cardiovascular disease. Prim Care. 2013;40(1):195–211.
Google Scholar | Crossref | Medline42. Bandyopadhyay, D, Qureshi, A, Ghosh, S, et al. Safety and efficacy of extremely low LDL-cholesterol levels and its prospects in hyperlipidemia management. J Lipids. 2018. doi:10.1155/ 2018/8598054
Google Scholar43. Cholesterol Treatment Trialists’ (CTT) Collaborators . The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet. 2012;380(9841):581–590.
Google Scholar | Crossref | Medline | ISI44. Bak, EJ, Kim, J, Jang, S, et al. Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. Scand J Clin Lab Invest. 2013;73(8):607–614.
Google Scholar | Crossref | Medline45. Yang, MH, Vasquez, Y, Ali, Z, Khan, IA, Khan, SI. Constituents from Terminalia species increase PPARα and PPARγ levels and stimulate glucose uptake without enhancing adipocyte differentiation. J Ethnopharmacol. 2013;149(2):490–498.
Google Scholar | Crossref | Medline46. Zhang, Y, Xiang, R, Fang, S, Huang, K, Fan, Y, Liu, T. Experimental study on the effect of Tibetan medicine triphala on the proliferation and apoptosis of pancreatic islet β cells through incretin-cAMP signaling pathway. Biol Pharm Bull. 2020;43(2):289–295.
Google Scholar | Crossref | Medline47. Chehregosha, H, Khamseh, ME, Malek, M, Hosseinpanah, F, Ismail-Beigi, F. A view beyond HbA1c: role of continuous glucose monitoring. Diabetes Ther. 2019;10(3):853–863.
Google Scholar | Crossref | Medline48. Gurjar, S, Pal, A, Kapur, S. Triphala and its constituents ameliorate visceral adiposity from a high-fat diet in mice with diet-induced obesity. Altern Ther Health Med. 2012;18(6):38–45.
Google Scholar | Medline49. Dludla, PV, Nkambule, BB, Jack, B, et al. Inflammation and oxidative stress in an obese state and the protective effects of gallic acid. Nutrients. 2018;11(1):23. pii:E23. doi: 10.3390/nu11010023
Google Scholar | Crossref50. Cercato, C, Fonseca, FA. Cardiovascular risk and obesity. Diabetol Metab Syndr. 2019;11. Article number: 74.
Google Scholar51. Aprahamian, TR, Sam, F. Adiponectin in cardiovascular inflammation and obesity. Int J Inflam. 2011;2011:376909. doi:10.4061/2011/376909
Google Scholar | Crossref | Medline52. Gagnier, JJ, Boon, H, Rochon, P, Moher, D, Barnes, J, Bombardier, C. Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement. Ann Intern Med. 2006;144(5):364–367.
Google Scholar | Crossref | Medline

留言 (0)

沒有登入
gif