Abuharfeil NM, Sukhon SE, Msameh Y, Sallal A-KJ (1999) Effect of date fruits, Phoenix Dactyliferia L., on the hemolytic activity of Streptolysin O. Pharm Biol 37:335–339

Article  Google Scholar 

Al-Farsi M, Alasalvar C, Morris A, Baron M, Shahidi F (2005) Compositional and sensory characteristics of three native sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. J Agric Food Chem 53:7586–7591

CAS  Article  PubMed  Google Scholar 

Al-Maiman SA (2005) Effect of date palm (Phoenix dactylifera) seed fibers on plasma lipids in rats. J King Saud Univ Agric Sci 17:117–123

Google Scholar 

Al-Qarawi AA, Mousa HM, Ali BH, Abdel-Rahman H, El-Mougy SA (2004) Protective effect of extracts from dates (Phoenix dactylifera L.) on carbon tetrachloride-induced hepatotoxicity in rats. Int J Appl Res Vet Med 2:176–180

Google Scholar 

Al-Qarawi A, Abdel-Rahman H, Ali B, Mousa H, El-Mougy S (2005) The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats. J Ethnopharmacol 98:313–317

CAS  Article  PubMed  Google Scholar 

Al-Qarawi A, Abdel-Rahman H, Mousa H, Ali B, El-Mougy S (2008) Nephroprotective action of Phoenix dactylifera. in gentamicin-induced nephrotoxicity. Pharm Biol 46:227–230

Article  Google Scholar 

Baliga MS, Baliga BRV, Kandathil SM, Bhat HP, Vayalil PK (2011) A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.). Food Res Int 44:1812–1822

CAS  Article  Google Scholar 

Bauza E, Dal Farra C, Berghi A, Oberto G, Peyronel D, Domloge N (2001) Date palm kernel extract exhibits antiaging properties and significantly reduces skin wrinkles. Int J Tissue React 24:131–136

Google Scholar 

Cheng CY, Su SY, Tang NY, Ho TY, Chiang SY, Hsieh CL (2008) Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats. Brain Res 1209:136–150

CAS  Article  PubMed  Google Scholar 

Chuanphongpanich S, Phanichphant S (2006) Method development and determination of phenolic compounds in broccoli seeds samples. Chiang Mai J Sci 33:103–107

CAS  Google Scholar 

El-Ameen NMH, Taha MME, Abdelwahab SI, Khalid A, Elfatih F, Kamel MA, Sheikh BY (2015) Anti-diabetic properties of thymoquinone is unassociated with glycogen phosphorylase inhibition. Phcog J 7:406–410

CAS  Article  Google Scholar 

El-Mougy S, Abdel-Aziz S, Al-Shanawany M, Omar A (1991) The gonadotropic activity of Palmae in mature male rats. Alex J Pharm Sci 5:156–159

Google Scholar 

ffrench-Mullen JM, Barker JL, Rogawski MA (1993) Calcium current block by (−)-pentobarbital, phenobarbital, and CHEB but not (+)-pentobarbital in acutely isolated hippocampal CA1 neurons: comparison with effects on GABA-activated Cl- current. J Neurosci 13:3211–3221

CAS  PubMed  Google Scholar 

García M, Michelangeli F, Fernández Á, Villamizar JE, Salazar F, Taylor P (2013) Anti-inflammatory effects of (+)-catechin isolated from the bark of Byrsonima crassifolia. Planta Med 79:PF12

Google Scholar 

Giacalone M, Di Sacco F, Traupe I, Topini R, Forfori F, Giunta F (2011) Antioxidant and neuroprotective properties of blueberry polyphenols: a critical review. Nutr Neurosci 14:119–125

CAS  Article  PubMed  Google Scholar 

Gill L (1992) Ethnomedical uses of plants in Nigeria. Uniben Press, Benin

Google Scholar 

Guido F et al. (2011) Chemical and aroma volatile compositions of date palm (Phoenix dactylifera L.) fruits at three maturation stages. Food Chem 127:1744–1754

Article  Google Scholar 

Halabi MF, Sheikh BY (2014) Anti-proliferative effect and phytochemical analysis of Cymbopogon citratus extract. BioMed Res Int 2014:906239

Article  PubMed  PubMed Central  Google Scholar 

Hmamouchi M (1999) Les plantes médicinales et aromatiques marocaines: utilisation, biologie, écologie, chimie, pharmacologie, toxicologie, lexiques. Imprimerie de Fédala, Mohammedia

Google Scholar 

Hong YJ, Tomas-Barberan FA, Kader AA, Mitchell AE (2006) The flavonoid glycosides and procyanidin composition of Deglet Noor dates (Phoenix dactylifera). J Agric Food Chem 54:2405–2411

CAS  Article  PubMed  Google Scholar 

Ishurd O, Kennedy JF (2005) The anti-cancer activity of polysaccharide prepared from Libyan dates (Phoenix dactylifera L.). Carbohydr Polym 59:531–535

CAS  Article  Google Scholar 

Islam MK et al. (2014) Antinociceptive and antioxidant activity of Zanthoxylum budrunga Wall (Rutaceae) seeds. Sci World J 2014:869537

Google Scholar 

Jassim SA, Naji MA (2010) In vitro evaluation of the antiviral activity of an extract of date palm (Phoenix dactylifera L.) pits on a Pseudomonas phage. Evid Based Complement Alternat Med 7:57–62

Article  PubMed  Google Scholar 

Kalantaripour T, Asadi-Shekaari M, Basiri M, Najar AG (2012) Cerebroprotective effect of date seed extract (Phoenix dactylifera) on focal cerebral ischemia in male rats. J Biol Sci 12:180–185

Article  Google Scholar 

Katsumichi M, Ryuichi M, Nobuki M (1997) Pulverized dried plants as sleeping aids. Japanese patent, JP 09023851, Available from SciFinder Scholar (25 June 2015)

Kikuchi N, Miki T (1978) The separation of date (Phoenix dactylifera) sterols by liquid chromatography. Microchim Acta 69:89–96

Article  Google Scholar 

Lorke D (1983) A new approach to practical acute toxicity testing. Arch Toxicol 54:275–287

CAS  Article  PubMed  Google Scholar 

Luo L, Sun Y (2011) Neuroprotective effect of ferulic acid in vitro. Zhong Yao Cai 34:1750–1753

CAS  PubMed  Google Scholar 

Lv WH, Zhang L, Wu SJ, Chen SZ, Zhu XB, Pan JC (2013) Analgesic effect of ferulic acid on CCl mice: behavior and neurobiological analysis. Zhongguo Zhong Yao Za Zhi 38:3736–3741

PubMed  Google Scholar 

Mandel S, Youdim MBH (2004) Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free Radic Biol Med 37:304–317

CAS  Article  PubMed  Google Scholar 

Mansouri A, Embarek G, Kokkalou E, Kefalas P (2005) Phenolic profile and antioxidant activity of the Algerian ripe date palm fruit (Phoenix dactylifera). Food Chem 89:411–420

CAS  Article  Google Scholar 

Maulidiani M, Sheikh BY, Mediani A, Wei LS, Ismail IS, Abas F, Lajis NH (2015) Differentiation of Nigella sativa seeds from four different origins and their bioactivity correlations based on NMR-metabolomics approach. Phytochem Lett 13:308–318

CAS  Article  Google Scholar 

Mohamadin AM, Sheikh B, El-Aal AAA, Elberry AA, Al-Abbasi FA (2010) Protective effects of Nigella sativa oil on propoxur-induced toxicity and oxidative stress in rat brain regions. Pestic Biochem Physiol 98:128–134

CAS  Article  Google Scholar 

Mohamed DA, Al-Okabi S (2004) In vivo evaluation of antioxidant and anti-inflammatory activity of different extracts of date fruits in adjuvant arthritis. Pol J Food Nutr Sci 13:397–402

Google Scholar 

Mondal H et al. (2014) Central-stimulating and analgesic activity of the ethanolic extract of Alternanthera sessilis in mice. BMC Complement Altern Med 14:398

Article  PubMed  PubMed Central  Google Scholar 

Murata T et al. (1997) Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 388:678–682

CAS  Article  PubMed  Google Scholar 

Nehlig A (2013) The neuroprotective effects of cocoa flavanol and its influence on cognitive performance. Br J Clin Pharmacol 75:716–727

CAS  PubMed  PubMed Central  Google Scholar 

Ozaki Y (1992) Antiinflammatory effect of tetramethylpyrazine and ferulic acid. Chem Pharm Bull 40:954–956

CAS  Article  PubMed  Google Scholar 

Pujari RR, Vyawahare NS, Kagathara VG (2011) Evaluation of antioxidant and neuroprotective effect of date palm (Phoenix dactylifera L.) against bilateral common carotid artery occlusion in rats. Indian J Exp Biol 49:627–633

PubMed  Google Scholar 

Puri A, Sahai R, Singh KL, Saxena R, Tandon J, Saxena K (2000) Immunostimulant activity of dry fruits and plant materials used in Indian traditional medical system for mothers after child birth and invalids. J Ethnopharmacol 71:89–92

CAS  Article  PubMed  Google Scholar 

Selvam A (2008) Inventory of vegetable crude drug samples housed in botanical survey of India, Howrah. Pharmacogn Rev 2:61–94

Google Scholar 

Shanmugapriya M, Patwardhan K (2012) Uses of date palm in Ayurveda. In: Manickavasagan A, Essa MM, Sukumar E (eds) Dates: production, processing, food, and medicinal values. CRC Press, Boca Raton, pp. 377–385

Google Scholar 

Sheikh BY, Mohamadin AM (2012) Thymoquinone a potential therapy for cerebral oxidative stress. Asian J Nat Appl Sci 1:76–92

Google Scholar 

Sheikh BY, Elsaed WM, Samman AH, Sheikh BY, Ladin A-MMB (2014) Ajwa dates as a protective agent against liver toxicity in rat. Eur Sci J 10:358–368

Google Scholar 

Shilpi JA, Uddin SJ, Rouf R, Billah MM (2004) Central nervous system depressant activity of Diospyros peregrina bark. Orient Pharm Exp Med 4:249–252

Article  Google Scholar 

Shraideh ZA, Abu-Elteen KH, Sallal A-KJ (1998) Ultrastructural effects of date extract on Candida albicans. Mycopathologia 142:119–123

CAS  Article  PubMed  Google Scholar 

Taha MME et al. (2015) Effectiveness of Sidr Honey on the prevention of ethanol-induced gastroulcerogenesis: role of antioxidant and antiapoptotic mechanism. Phcog J 7:157–164

CAS  Article  Google Scholar 

Takagi K, Wantanabe M, Saito H (1971) Studies of the spontaneous movement of animals by the hole cross test; effect of 2-dimethyl-aminoethanol and its acyl esters on the central nervous system. Jpn J Pharmacol 21:797–810

CAS  Article  PubMed  Google Scholar 

Tian Y (2014) A seaweed-blueberry compound beverage and processing method. Chinese patent, CN 103989221, Available from SciFinder Scholar (25 June 2015)

Uddin S, Shilpi J, Rahman M, Ferdous M, Rouf R, Sarker S (2006) Assessment of neuropharmacological activities of Pandanus foetidus (Pandanaceae) in mice. Pharmazie 61:362–364

CAS  PubMed  Google Scholar 

Vayalil PK (2002) Antioxidant and antimutagenic properties of aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae). J Agric Food Chem 50:610–617

CAS  Article  PubMed  Google Scholar 

Wang H, Cao Z (2014) Anti-inflammatory Effects of (−)-epicatechin in lipopolysaccharide-stimulated RAW 264.7 macrophages. Trop J Pharm Res 13:1415–1419

CAS  Article  Google Scholar 

Wang JY, Wen LL, Huang YN, Chen YT, Ku MC (2006) Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Curr Pharm Des 12:3521–3533

CAS