1. World Health Organization. Cancer . 2021. https://www.who.int/news-room/fact-sheets/detail/cancer. https://www.who.int/news-room/fact-sheets/detail/cancer. Accessed October 1, 2021.
Google Scholar2. Rivas-Santiago, C, González-Curiel, I, Zarazua, S, Murgu, M, Ruiz Cardona, A, Lazalde, B, et al. Lipid metabolism alterations in a rat model of chronic and intergenerational exposure to arsenic. BioMed Res Int. 2019;2019:4978018.
Google Scholar | Crossref | Medline3. Irshad, K, Rehman, K, Fiayyaz, F, Sharif, H, Murtaza, G, Kamal, S, et al. Role of heavy metals in metabolic disorders. In: Akash, MSH, Rehman, K, Hashmi, MZ, eds. Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies. Emerging Contaminants and Associated Treatment Technologies. Switzerland AG: Springer Nature; 2021:203-219.
Google Scholar | Crossref4. Rehman, K, Fatima, F, Akash, MSH. Biochemical investigation of association of arsenic exposure with risk factors of diabetes mellitus in Pakistani population and its validation in animal model. Environ Monit Assess. 2019;191:511.
Google Scholar | Crossref | Medline5. Sohel, N, Persson, LÅ, Rahman, M, Streatfield, PK, Yunus, M, Ekström, E-C, et al. Arsenic in drinking water and adult mortality: a population-based cohort study in rural Bangladesh. Epidemiology. 2009;20:824-830.
Google Scholar | Crossref | Medline6. Jomova, K, Jenisova, Z, Feszterová, M, Baros, S, Liska, J, Hudecova, D, et al. Arsenic: Toxicity, oxidative stress and human disease. J Appl Toxicol. 2011;31:95-107.
Google Scholar | Medline | ISI7. Diaz, Z, Colombo, M, Mann, KK, Su, H, Smith, KN, Bohle, DS, et al. Trolox selectively enhances arsenic-mediated oxidative stress and apoptosis in APL and other malignant cell lines. Blood. 2005;105:1237-1245.
Google Scholar | Crossref | Medline8. Binu, P, Priya, N, Abhilash, S, Vineetha, RC, Nair, H. Protective effects of eugenol against hepatotoxicity induced by arsenic trioxide: An antileukemic drug. Iran J Med Sci. 2018;43:305-312.
Google Scholar | Medline9. Hughes, MF, Beck, BD, Chen, Y, Lewis, AS, Thomas, DJ. Arsenic exposure and toxicology: a historical perspective. Toxicol Sci. 2011;123:305-332.
Google Scholar | Crossref | Medline | ISI10. Paul, MK, Kumar, R, Mukhopadhyay, AK. Dithiothreitol abrogates the effect of arsenic trioxide on normal rat liver mitochondria and human hepatocellular carcinoma cells. Toxicol Appl Pharmacol. 2008;226:140-152.
Google Scholar | Crossref | Medline11. Vantroyen, B, Heilier, JF, Meulemans, A, Michels, A, Buchet, JP, Vanderschueren, S, et al. Survival after a lethal dose of arsenic trioxide. J Toxicol Clin Toxicol. 2004;42:889-895.
Google Scholar | Crossref | Medline12. Ficker, E, Kuryshev, YA, Dennis, AT, Obejero-Paz, C, Wang, L, Hawryluk, P, et al. Mechanisms of arsenic-induced prolongation of cardiac repolarization. Mol Pharmacol. 2004;66:33-44.
Google Scholar | Crossref | Medline | ISI13. Cohen, SM, Arnold, LL, Eldan, M, Lewis, AS, Beck, BD. Methylated arsenicals: The implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit Rev Toxicol. 2006;36:99-133.
Google Scholar | Crossref | Medline | ISI14. Csanaky, I, Gregus, Z. Role of glutathione in reduction of arsenate and of γ-glutamyltranspeptidase in disposition of arsenite in rats. Toxicology. 2005;207:91-104.
Google Scholar | Crossref | Medline15. Reichard, JF, Puga, A. Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics. 2010;2:87-104.
Google Scholar | Crossref | Medline16. Susan, A, Rajendran, K, Sathyasivam, K, Krishnan, UM. An overview of plant-based interventions to ameliorate arsenic toxicity. Biomed Pharmacother. 2019;109:838-852.
Google Scholar | Crossref | Medline17. Li, Z, Piao, F, Liu, S, Wang, Y, Qu, S. Subchronic exposure to arsenic trioxide-induced oxidative DNA damage in kidney tissue of mice. Exp Toxicol Pathol. 2010;62:543-547.
Google Scholar | Crossref | Medline | ISI18. Suzuki, T, Tsukamoto, I. Arsenite induces apoptosis in hepatocytes through an enhancement of the activation of Jun N-terminal kinase and p38 mitogen-activated protein kinase caused by partial hepatectomy. Toxicol Lett. 2006;165:257-264.
Google Scholar | Crossref | Medline19. Bashir, S, Sharma, Y, Irshad, M, Nag, TC, Tiwari, M, Kabra, M, et al. Arsenic induced apoptosis in rat liver following repeated 60 days exposure. Toxicology. 2006;217:63-70.
Google Scholar | Crossref | Medline20. Afsheen, N, Jahan, N. Attenuation of chemically induced diabetes in rabbits with herbal mixture (Citrullus colocynthis and Cicer arietinum). Pak Vet J. 2013;33:41-44.
Google Scholar21. Hu, J, Zhang, B, Du, L, Chen, J, Lu, Q. Resveratrol ameliorates cadmium induced renal oxidative damage and inflammation. Int J Clin Exp. 2017;10:7563-7572.
Google Scholar22. Salehi, B, Mishra, AP, Nigam, M, Sener, B, Kilic, M, Sharifi-Rad, M, et al. Resveratrol: A double-edged sword in health benefits. Biomedicines. 2018;6:91.
Google Scholar | Crossref23. Risuleo, G . Resveratrol: Multiple activities on the biological functionality of the cell. In: Gupta, RC , ed. Nutraceuticals. Boston: Academic Press; 2016:453-464.
Google Scholar | Crossref24. Hassan-Khabbar, S, Cottart, C-H, Wendum, D, Vibert, F, Clot, J-P, Savouret, J-F, et al. Postischemic treatment bytrans-resveratrol in rat liver ischemia-reperfusion: A possible strategy in liver surgery. Liver Transpl. 2008;14:451-459.
Google Scholar | Crossref | Medline | ISI25. Ramanathan, K, Shila, S, Kumaran, S, Panneerselvam, C. Protective role of ascorbic acid and a-tocopherol on arsenic-induced microsomal dysfunctions. Hum Exp Toxicol. 2003;22:129-136.
Google Scholar | SAGE Journals | ISI26. Singh, S, Rana, S. Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat. Indian J Exp Biol. 2007;45:371-375.
Google Scholar | Medline27. Sohini, Rana, SVS Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat. Indian J Exp Biol. 2007;45:371-375.
Google Scholar | Medline28. Zhang, W, Liu, Y, Ge, M, Jing, J, Chen, Y, Jiang, H, et al. Protective effect of resveratrol on arsenic trioxide-induced nephrotoxicity in rats. Nutr Res Pract. 2014;8:220-226.
Google Scholar | Crossref | Medline29. Mohammed, E, Mohammed, T, Mohammed, A. Optimization of an acid digestion procedure for the determination of Hg, As, Sb, Pb and Cd in fish muscle tissue. MethodsX. 2017;4:513-523.
Google Scholar | Crossref | Medline30. Sabir, S, Akash, MSH, Rehman, K, Saleem, U, Fiayyaz, F, Ahmad, T. Assessment of heavy metals by ICP-OES and their impact on insulin stimulating hormone and carbohydrate metabolizing enzymes. Clin Exp Pharmacol Physiol. 47. 2020:1682, 1691.
Google Scholar | Medline31. Yu, M, Xue, J, Li, Y, Zhang, W, Ma, D, Liu, L, et al. Resveratrol protects against arsenic trioxide-induced nephrotoxicity by facilitating arsenic metabolism and decreasing oxidative stress. Arch Toxicol. 2013;87:1025-1035.
Google Scholar | Crossref | Medline32. Miller, WH, Schipper, HM, Lee, JS, Singer, J, Waxman, S. Mechanisms of action of arsenic trioxide. Cancer Res. 2002;62:3893-3903.
Google Scholar | Medline | ISI33. Bagchi, D, Bagchi, M, Stohs, SJ, Das, DK, Ray, SD, Kuszynski, CA, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000;148:187-197.
Google Scholar | Crossref | Medline | ISI34. Sayed, S, Ahsan, N, Kato, M, Ohgami, N, Rashid, A, Akhand, AA. Protective effects of phyllanthus emblica leaf extract on sodium arsenite-mediated adverse effects in mice. Nagoya J Med Sci. 2015;77:145-153.
Google Scholar | Medline35. Dua, TK, Dewanjee, S, Gangopadhyay, M, Khanra, R, Zia-Ul-Haq, M, De Feo, V. Ameliorative effect of water spinach, Ipomea aquatica (Convolvulaceae), against experimentally induced arsenic toxicity. J Transl Med. 2015;13:81.
Google Scholar | Crossref | Medline36. Anwar-Mohamed, A, Abdelhamid, G, Amara, IEA, El-Kadi, AOS. Differential modulation of aryl hydrocarbon receptor regulated enzymes by arsenite in the kidney, lung, and heart of C57BL/6 mice. Arch Toxicol. 2012;86:897-910.
Google Scholar | Crossref | Medline37. Kapaj, S, Peterson, H, Liber, K, Bhattacharya, P. Human Health Effects From Chronic Arsenic Poisoning-A Review. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2006;41:2399-2428.
Google Scholar | Crossref | Medline38. Flora, SJS, Mehta, A, Gautam, P, Jatav, PC, Pathak, U. Essential metal status, prooxidant/antioxidant effects of MiADMSA in male rats: age-related effects. Biol Trace Elem Res. 2007;120:235-247.
Google Scholar | Crossref | Medline39. Young, IS, Woodside, JV. Antioxidants in health and disease. J Clin Pathol. 2001;54:176-186.
Google Scholar | Crossref | Medline | ISI40. Albertoni, G, Schor, N. Resveratrol plays important role in protective mechanisms in renal disease--mini-review. J Bras Nefrol. 2015;37:106-114.
Google Scholar | Crossref | Medline41. Manna, P, Sinha, M, Sil, PC. Arsenic-induced oxidative myocardial injury: Protective role of arjunolic acid. Arch Toxicol. 2008;82:137-149.
Google Scholar | Crossref | Medline | ISI42. Yoshikawa, T, Tanaka, H, Yoshida, N, Seto, O, Sugino, N, Kondo, M. Adjuvant arthritis and lipid peroxide protection by superoxide dismutase. Lipid Peroxide Res. 1983;7:108-110.
Google Scholar43. Bhadauria, S, Flora, SJ. Arsenic induced inhibition of delta-aminolevulinate dehydratase activity in rat blood and its response to meso 2,3-dimercaptosuccinic acid and monoisoamyl DMSA. Biomed Environ Sci. 2004;17:101-108.
Google Scholar | Medline44. Bhatt, K, Flora, SJS. Oral co-administration of α-lipoic acid, quercetin and captopril prevents gallium arsenide toxicity in rats. Environ Toxicol Pharmacol. 2009;28:140-146.
Google Scholar | Crossref | Medline45. Brinkel, J, Khan, M, Kraemer, A. A systematic review of arsenic exposure and its social and mental health effects with special reference to Bangladesh. Int J Environ Res Public Health. 2009;6:1609-1619.
Google Scholar | Crossref | Medline | ISI46. Yamanaka, K, Hasegawa, A, Sawamura, R, Okada, S. Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice. Toxicol Appl Pharmacol. 1991;108:205-213.
Google Scholar | Crossref | Medline | ISI47. Gupta, R, Kannan, GM, Sharma, M, Flora, SJ. Therapeutic effects of Moringa oleifera on arsenic-induced toxicity in rats. Environ Toxicol Pharmacol. 2005;20:456-464.
Google Scholar | Crossref | Medline | ISI48. Saxena, G, Flora, SJS. Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. J Biochem Mol Toxicol. 2004;18:221-233.
Google Scholar | Crossref | Medline | ISI49. Liu, SX, Athar, M, Lippai, I, Waldren, C, Hei, TK. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc Natl Acad Sci USA. 2001;98:1643-1648.
Google Scholar | Crossref | Medline |