Epicatechin ameliorative effects on methotrexate-induced hepatotoxicity in mice

1. Skubisz, MM, Tong, S. The evolution of methotrexate as a treatment for ectopic pregnancy and gestational trophoblastic neoplasia: a review. ISRN Obstet Gynecol 2012; 2012: 637094.
Google Scholar | Crossref | Medline2. Mehrzadi, S, Mehrabani, M, Malayeri, AR, et al. Ellagic acid as a potential antioxidant, alleviates methotrexate-induced hepatotoxicity in male rats. Acta Chirurgica Belgica 2019; 119(2): 69–77.
Google Scholar | Crossref | Medline3. Hannoodee, M, Mittal, M. Methotrexate. StatPearls [Internet] 2020; 1–12.
Google Scholar4. Hassanein, EHM, Mohamed, WR, Shalkami, AGS, et al. Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P38MAPK/NF-κB, and apoptosis signaling pathways. Food Chem Toxicol 2018; 116: 152–160.
Google Scholar | Crossref | Medline5. Rajagopalan, PTR, Zhang, Z, McCourt, L, et al. Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. Roc Natl Acad Sci U S A 2002; 99(21): 13481–13486.
Google Scholar | Crossref | Medline6. Tian, H, Cronstein, BN. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis 2007; 65(3): 168–173.
Google Scholar | Medline7. Chan, ES, Cronstein, BN. Mechanisms of action of methotrexate. Bull NYU Hosp Jt Dis 2013; 71(suppl 1): S5–S8.
Google Scholar8. Maksimovic, V, Pavlovic-Popovic, Z, Vukmirovic, S, et al. Molecular mechanism of action and pharmacokinetic properties of methotrexate. Mol Biol Rep 2020; 47(6): 4699–4708.
Google Scholar | Crossref | Medline9. El-Sheikh, AA, Morsy, MA, Hamouda, AH. Protective mechanisms of thymoquinone on methotrexate-induced intestinal toxicity in rats. Pharmacogn Mag 2016; 12(Suppl 1): S76–S81.
Google Scholar | Medline10. Gao, Y, Sun, Q, Yang, X, et al. Orally administered salecan ameliorates methotrexate-induced intestinal mucositis in mice. Cancer Chemother Pharmacol 2019; 84(1): 105–116.
Google Scholar | Crossref | Medline11. Mori, S, Hidaka, M, Kawakita, T, et al. Factors associated with myelosuppression related to low-dose methotrexate therapy for inflammatory rheumatic diseases. PLoS One 2016; 11(4): e0154744.
Google Scholar | Crossref | Medline12. Ahmed, J, Abdulmajeed, I. Effect of Nigella sativa (black seeds) against methotrexate-induced nephrotoxicity in mice. J Intercult Ethnopharmacol 2017; 6(1): 9.
Google Scholar | Crossref | Medline13. Heidari Khoei, H, Fakhri, S, Parvardeh, S, et al. Astaxanthin prevents the methotrexate-induced reproductive toxicity by targeting oxidative stress in male mice. Toxin Rev 2019; 38(3): 248–254.
Google Scholar | Crossref14. Conway, R, Carey, JJ. Risk of liver disease in methotrexate treated patients. World J Hepatol 2017; 9(26): 1092.
Google Scholar | Crossref | Medline15. Bu, T, Wang, C, Meng, Q, et al. Hepatoprotective effect of rhein against methotrexate-induced liver toxicity. Eur J Pharmacol 2018; 834: 266–273.
Google Scholar | Crossref | Medline16. Scalbert, A, Manach, C, Morand, C, et al. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 2005; 45(4): 287–306.
Google Scholar | Crossref | Medline | ISI17. Cordero‐Herrera, I, Martín, MA, Goya, L, et al. Cocoa flavonoids protect hepatic cells against high‐glucose‐induced oxidative stress. Relevance of MAPKs. Mol Nutr Food Res 2015; 59(4): 597–609.
Google Scholar | Crossref | Medline18. González-Gallego, J, García-Mediavilla, MV, Sánchez-Campos, S, et al. Anti-inflammatory, immunomodulatory, and prebiotic properties of dietary flavonoids. Polyphenols: Prevention and Treatment of Human Disease. 2th ed.. Elsevier, 2018, pp. 327–345.
Google Scholar | Crossref19. Bors, W, Michel, C, Saran, M. Flavonoid antioxidants: rate constants for reactions with oxygen radicals. Methods Enzymol 1994; 234: 420–429.
Google Scholar | Crossref | Medline20. Shay, J, Elbaz, HA, Lee, I, et al. Molecular mechanisms and therapeutic effects of (−)-epicatechin and other polyphenols in cancer, inflammation, diabetes, and neurodegeneration. Oxid Med Cell Longev 2015; 2015: 181260.
Google Scholar | Crossref | Medline21. Mohamed, RH, Karam, RA, Amer, MG. Epicatechin attenuates doxorubicin-induced brain toxicity: critical role of TNF-α, iNOS and NF-κB. Brain Res Bull 2011; 86(1–2): 22–28.
Google Scholar | Crossref | Medline22. Al-Hanbali, M, Ali, D, Bustami, M, et al. Epicatechin suppresses IL-6, IL-8 and enhances IL-10 production with NF-kappaB nuclear translocation in whole blood stimulated system. Neuro Endocrinol Lett 2009; 30(1): 131–138.
Google Scholar | Medline23. Abdel-Daim, MM, Khalifa, HA, Abushouk, AI, et al. Diosmin attenuates methotrexate-induced hepatic, renal, and cardiac injury: a biochemical and histopathological study in mice. Oxid Med Cell Longev 2017; 2017: 3281670.
Google Scholar | Crossref | Medline24. Shariati, S, Kalantar, H, Pashmforoosh, M, et al. Epicatechin protective effects on bleomycin-induced pulmonary oxidative stress and fibrosis in mice. Biomed Pharmacother 2019; 114: 108776.
Google Scholar | Crossref | Medline25. Helmerhorst, E, Stokes, GB. Microcentrifuge desalting: a rapid, quantitative method for desalting small amounts of protein. Anal Biochem 1980; 104(1): 130–135.
Google Scholar | Crossref | Medline26. Góth, L . A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 1991; 196(2–3): 143–151.
Google Scholar | Crossref | Medline27. Ellman, GL . Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82(1): 70–77.
Google Scholar | Crossref | Medline | ISI28. Buege, JA, Aust, SD. Microsomal lipid peroxidation. Methods in Enzymology 1978; 52: 302–310.
Google Scholar | Crossref | Medline29. Kalantar, M, Kalantari, H, Goudarzi, M, et al. Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats. Pharmacol Rep 2019; 71(4): 746–752.
Google Scholar | Crossref | Medline30. Archer, S . Measurement of nitric oxide in biological models. FASEB J 1993; 7(2): 349–360.
Google Scholar | Crossref | Medline31. Mahmoud, AM, Hussein, OE, Hozayen, WG, et al. Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats. Environ Sci Pollut Res 2020; 27(8): 7910–7921.
Google Scholar | Crossref | Medline32. Kalantari, H, Asadmasjedi, N, Abyaz, MR, et al. Protective effect of inulin on methotrexate- induced liver toxicity in mice. Biomed Pharmacother 2019; 110: 943–950.
Google Scholar | Crossref | Medline33. Tsikas, D . Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem 2017; 524: 13–30.
Google Scholar | Crossref | Medline34. Marnett, LJ . Chemistry and biology of DNA damage by malondialdehyde. IARC Sci Publ 1999; (150): 17–27.
Google Scholar | Medline35. Wu, H, Xie, Y, Xu, Y, et al. Protective effect of Epicatechin on APAP-induced acute liver injury of mice through anti-inflammation and apoptosis inhibition. Nat Prod Res 2020; 34(6): 855–858.
Google Scholar | Crossref | Medline36. Ali, N, Rashid, S, Nafees, S, et al. Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis. Mol Cell Biochem 2014; 385(1–2): 215–223.
Google Scholar | Crossref | Medline | ISI37. Badr, GM . Ameliorative effect of propolis extract on hepatotoxicity induced by methotrexate in mice. Asian J Appl Sci (ISSN: 2321–0893) 2016; 4(04): 963–970.
Google Scholar38. Ali, N, Rashid, S, Nafees, S, et al. Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: an experimental approach. Chem Biol Interact 2017; 272: 80–91.
Google Scholar | Crossref | Medline39. Ahmed, OM, Abdul-Hamid, MM, El-Bakry, AM, et al. Camellia sinensis and epicatechin abate doxorubicin-induced hepatotoxicity in male Wistar rats via their modulatory effects on oxidative stress, inflammation, and apoptosis. J Appl Pharm Sci 2019; 9(04): 030–044.
Google Scholar | Crossref40. Al-Malki, AL, Moselhy, SS. Protective effect of vitamin E and epicatechin against nicotine-induced oxidative stress in rats. Toxicol Ind Health 2013; 29(2): 202–208.
Google Scholar | SAGE Journals | ISI41. Fouad, A, Hafez, H, Hamouda, A. Hydrogen sulfide modulates IL-6/STAT3 pathway and inhibits oxidative stress, inflammation, and apoptosis in rat model of methotrexate hepatotoxicity. Hum Exp Toxicol 2020; 39(1): 77–85.
Google Scholar | SAGE Journals | ISI42. Badr, GM, Arafa, NS. Synergetic effect of aged garlic extract and methotrexate on rheumatoid arthritis induced by collagen in male albino rats. Indian J Exp Biol 2020; 58(1): 33–38.
Google Scholar43. Zhang, H, Deng, A, Zhang, Z, et al. The protective effect of epicatechin on experimental ulcerative colitis in mice is mediated by increasing antioxidation and by the inhibition of NF-κB pathway. Pharmacol Rep 2016; 68(3): 514–520.
Google Scholar | Crossref | Medline44. Noll, C, Lameth, J, Paul, JL, et al. Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice. Eur J Nutr 2013; 52(3): 1243–1250.
Google Scholar | Crossref | Medline45. Anand David, AV, Satyanarayana, N, Parasuraman, S, et al. Ameliorative effect of quercetin on methotrexate induced toxicity in sprague-dawley rats: a histopathological study. Indian J Pharm Educ Res 2016; 50: S200–S208.
Google Scholar | Crossref46. Uraz, S, Tahan, V, Aygun, C, et al. Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity. Dig Dis Sci 2008; 53(4): 1071–1077.
Google Scholar | Crossref | Medline47. Huang, Z, Jing, X, Sheng, Y, et al. (-)-Epicatechin attenuates hepatic sinusoidal obstruction syndrome by inhibiting liver oxidative and inflammatory injury. Redox Biol 2019; 22: 101117.
Google Scholar | Crossref | Medline48. Roghani, M, Kalantari, H, Khodayar, MJ, et al. Alleviation of liver dysfunction, oxidative stress and inflammation underlies the protective effect of ferulic acid in methotrexate-induced hepatotoxicity. Drug Des Development Ther 2020; 14: 1933–1941.
Google Scholar | Crossref | Medline

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