Rapamycin-induced M2 macrophage autophagy promotes the migration and invasion of bladder cancer cells via increased IL-10 secretion

1. Siegel, RL, Miller, KD, Jemal, A. Cancer statistics, 2019. CA Cancer J Clin 2019; 69: 7–34.
Google Scholar | Crossref | Medline2. van Rhijn, BWG, Burger, M, Lotan, Y, et al. Recurrence and progression of disease in non-muscle-invasive bladder cancer: from epidemiology to treatment strategy. Eur Urol 2009; 56: 430–442.
Google Scholar | Crossref | Medline | ISI3. Alfred Witjes, J, Lebret, T, Compérat, EM, et al. Updated 2016 EAU guidelines on muscle-invasive and metastatic bladder cancer. Eur Urol 2017; 71: 462–475.
Google Scholar | Crossref | Medline4. Necchi, A, Pond, GR, Raggi, D, et al. Efficacy and safety of gemcitabine plus either taxane or carboplatin in the first-line setting of metastatic urothelial carcinoma: a systematic review and meta-analysis. Clin Genitourin Cancer 2017; 15: 23–30, e22.
Google Scholar | Crossref | Medline5. Balar, AV, Castellano, D, O’Donnell, PH, et al. First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study. Lancet Oncol 2017; 18: 1483–1492.
Google Scholar | Crossref | Medline6. Carneiro, BA, Meeks, JJ, Kuzel, TM, et al. Emerging therapeutic targets in bladder cancer. Cancer Treat Rev 2015; 41: 170–178.
Google Scholar | Crossref | Medline | ISI7. Abbosh, PH, McConkey, DJ, Plimack, ER. Targeting signaling transduction pathways in bladder cancer. Curr Oncol Rep 2015; 17: 58.
Google Scholar | Crossref | Medline8. Wang, W, Chen, H, Liu, Z, et al. Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway. Br J Cancer 2016; 114: 305–313.
Google Scholar | Crossref | Medline9. Madka, V, Mohammed, A, Li, Q, et al. Targeting mTOR and p53 signaling inhibits muscle invasive bladder cancer in vivo. Cancer Prev Res (Phila) 2016; 9: 53–62.
Google Scholar | Crossref | Medline10. Milowsky, MI, Iyer, G, Regazzi, AM, et al. Phase II study of everolimus in metastatic urothelial cancer. BJU Int 2013; 112: 462–470.
Google Scholar | Crossref | Medline | ISI11. Xue, Y, Tong, L, LiuAnwei Liu, F, et al. Tumor-infiltrating M2 macrophages driven by specific genomic alterations are associated with prognosis in bladder cancer. Oncol Rep 2019; 42: 581–594.
Google Scholar | Medline12. Martínez, VG, Rubio, C, Martínez-Fernández, M, et al. BMP4 induces M2 macrophage polarization and favors tumor progression in bladder cancer. Clin Cancer Res 2017; 23: 7388–7399.
Google Scholar | Crossref | Medline13. Liu, J, Duan, X. PA-MSHA induces apoptosis and suppresses metastasis by tumor associated macrophages in bladder cancer cells. Cancer Cell Int 2017; 17: 76.
Google Scholar | Crossref | Medline14. Tong, H, Yin, H, Hossain, MA, et al. Starvation‐induced autophagy promotes the invasion and migration of human bladder cancer cells via TGF‐β1/Smad3‐mediated epithelial‐mesenchymal transition activation. J Cell Biochem 2019; 120: 5118–5127.
Google Scholar | Crossref | Medline15. Yang, X, Yin, H, Zhang, Y, et al. Hypoxia-induced autophagy promotes gemcitabine resistance in human bladder cancer cells through hypoxia-inducible factor 1α activation. Int J Oncol 2018; 53: 215–224.
Google Scholar | Medline16. Wang, F, Tang, J, Li, P, et al. Chloroquine enhances the radiosensitivity of bladder cancer cells by inhibiting autophagy and activating apoptosis. Cell Physiol Biochem 2018; 45: 54–66.
Google Scholar | Crossref | Medline17. Shao, L-N, Zhu, B-S, Xing, C-G, et al. Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells. Mol Med Rep 2016; 13: 2661–2670.
Google Scholar | Crossref | Medline18. Yang, M, Liu, J, Shao, J, et al. Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization. Mol Cancer 2014; 13: 43.
Google Scholar | Crossref | Medline19. Khare, V, Paul, G, Movadat, O, et al. IL10R2 overexpression promotes IL22/STAT3 signaling in colorectal carcinogenesis. Cancer Immunol Res 2015; 3: 1227–1235.
Google Scholar | Crossref | Medline20. Newton, MR, Askeland, EJ, Andresen, ED, et al. Anti-interleukin-10R1 monoclonal antibody in combination with bacillus Calmette-Guérin is protective against bladder cancer metastasis in a murine orthotopic tumour model and demonstrates systemic specific anti-tumour immunity. Clin Exp Immunol 2014; 177: 261–268.
Google Scholar | Crossref | Medline21. Yang, L, Dong, Y, Li, Y, et al. IL‐10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF‐κB/Notch1 pathway in non‐small cell lung cancer. Int J Cancer 2019; 145: 1099–1110.
Google Scholar | Crossref | Medline

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