Classification and Diagnosis of Diabetes. Standards of medical care in diabetes-2019. Diabetes Care. 2019;42(Suppl 1):S13–28.

Google Scholar 

Centers for Disease Control and Prevention. National diabetes statistics report A, GA: Centers for Disease Control and Prevention, US Department of Health and Human Services; 2017.

De Caterina R, Madonna R. Impaired fasting plasma glucose and long-term cardiovascular risk: still a foggy relationship. Eur Heart J. 2010;31(10):1159–62.

PubMed  Article  CAS  PubMed Central  Google Scholar 

Schöttker B, Müller H, Rothenbacher D, Brenner H. Fasting plasma glucose and HbA1c in cardiovascular risk prediction: a sex-specific comparison in individuals without diabetes mellitus. Diabetologia. 2013;56(1):92–100.

PubMed  Article  CAS  PubMed Central  Google Scholar 

Gordon-Dseagu VLZ, Mindell JS, Steptoe A, Moody A, Wardle J, Demakakos P, et al. Impaired glucose metabolism among those with and without diagnosed diabetes and mortality: a cohort study using health survey for England data. PLoS ONE. 2015;10(3):e0119882.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Selvin E, Lazo M, Chen Y, Shen L, Rubin J, McEvoy JW, et al. Diabetes mellitus, prediabetes, and incidence of subclinical myocardial damage. Circulation. 2014;130(16):1374–82.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Doi Y, Ninomiya T, Hata J, Fukuhara M, Yonemoto K, Iwase M, et al. Impact of glucose tolerance status on development of ischemic stroke and coronary heart disease in a general Japanese population: the Hisayama study. Stroke. 2010;41(2):203–9.

CAS  PubMed  Article  PubMed Central  Google Scholar 

de Ritter R, Sep SJS, van der Kallen CJH, van Greevenbroek MMJ, de Jong M, Vos RC, et al. Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: the Maastricht study. Cardiovasc Diabetol. 2021;20(1):102.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Åkerblom A, Wojdyla D, Steg PG, Wallentin L, James SK, Budaj A, et al. Prevalence and relevance of abnormal glucose metabolism in acute coronary syndromes: insights from the PLATelet inhibition and patient outcomes (PLATO) trial. J Thromb Thrombolysis. 2019;48(4):563–9.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Kiviniemi AM, Lepojarvi ES, Tulppo MP, Piira OP, Kentta TV, Perkiomaki JS, et al. Prediabetes and risk for cardiac death among patients with coronary artery disease: the ARTEMIS study. Diabetes Care. 2019;42(7):1319–25.

CAS  PubMed  Article  PubMed Central  Google Scholar 

Shahim B, De Bacquer D, De Backer G, Gyberg V, Kotseva K, Mellbin L, et al. The prognostic value of fasting plasma glucose, two-hour postload glucose, and HbA1c in patients with coronary artery disease: a report from EUROASPIRE IV: a survey from the European society of cardiology. Diabetes Care. 2017;40(9):1233–40.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tang WH, Wu Y, Nicholls SJ, Brennan DM, Pepoy M, Mann S, et al. Subclinical myocardial necrosis and cardiovascular risk in stable patients undergoing elective cardiac evaluation. Arterioscler Thromb Vasc Biol. 2010;30(3):634–40.

CAS  PubMed  Article  PubMed Central  Google Scholar 

Grodin JL, Neale S, Wu Y, Hazen SL, Tang WH. Prognostic comparison of different sensitivity cardiac troponin assays in stable heart failure. Am J Med. 2015;128(3):276–82.

PubMed  Article  PubMed Central  Google Scholar 

Tang WH, Wu Y, Britt EB Jr, Iqbal N, Hazen SL. Detectable subclinical myocardial necrosis is associated with cardiovascular risk in stable patients with diabetes. Diabetes Care. 2013;36(5):1126–31.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Rubin J, Matsushita K, Ballantyne CM, Hoogeveen R, Coresh J, Selvin E. Chronic hyperglycemia and subclinical myocardial injury. J Am Coll Cardiol. 2012;59(5):484–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Stevens LA, Schmid CH, Greene T, Zhang Y, Beck GJ, Froissart M, et al. Comparative performance of the CKD epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD) study equations for estimating GFR levels above 60 mL/min/1.73 m2. Am J Kidney Dis. 2010;56(3):486–95.

PubMed  PubMed Central  Article  Google Scholar 

Zhou Z, Sun B, Huang S, Zhu C, Bian M. Glycemic variability: adverse clinical outcomes and how to improve it? Cardiovasc Diabetol. 2020;19(1):102.

PubMed  PubMed Central  Article  Google Scholar 

Hartge MM, Unger T, Kintscher U. The endothelium and vascular inflammation in diabetes. Diabetes Vasc Dis Res. 2007;4(2):84–8.

Article  Google Scholar 

Witkowski M, Tabaraie T, Steffens D, Friebel J, Dörner A, Skurk C, et al. MicroRNA-19a contributes to the epigenetic regulation of tissue factor in diabetes. Cardiovasc Diabetol. 2018;17(1):34.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Paolisso P, Foà A, Bergamaschi L, Donati F, Fabrizio M, Chiti C, et al. Hyperglycemia, inflammatory response and infarct size in obstructive acute myocardial infarction and MINOCA. Cardiovasc Diabetol. 2021;20(1):33.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kakouros N, Rade JJ, Kourliouros A, Resar JR. Platelet function in patients with diabetes mellitus: from a theoretical to a practical perspective. Int J Endocrinol. 2011. https://doi.org/10.1155/2011/742719.

Article  PubMed  PubMed Central  Google Scholar 

Schuette C, Steffens D, Witkowski M, Stellbaum C, Bobbert P, Schultheiss HP, et al. The effect of clopidogrel on platelet activity in patients with and without type-2 diabetes mellitus: a comparative study. Cardiovasc Diabetol. 2015;14:15.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Kario K, Matsuo T, Kobayashi H, Matsuo M, Sakata T, Miyata T. Activation of tissue factor-induced coagulation and endothelial cell dysfunction in non-insulin-dependent diabetic patients with microalbuminuria. Arterioscler Thromb Vasc Biol. 1995;15(8):1114–20.

CAS  PubMed  Article  PubMed Central  Google Scholar 

Witkowski M, Witkowski M, Saffarzadeh M, Friebel J, Tabaraie T, Ta Bao L, et al. Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes. Cardiovasc Diabetol. 2020;19(1):20.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Witkowski M, Friebel J, Tabaraie T, Grabitz S, Dörner A, Taghipour L, et al. Metformin is associated with reduced tissue factor procoagulant activity in patients with poorly controlled diabetes. Cardiovasc Drugs Ther. 2021;35(4):809–13.

CAS  PubMed  Article  PubMed Central  Google Scholar 

Huang Y, Cai X, Mai W, Li M, Hu Y. Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis. BMJ. 2016;355:i5953.

PubMed  PubMed Central  Article  Google Scholar 

Tai ES, Goh SY, Lee JJ, Wong MS, Heng D, Hughes K, et al. Lowering the criterion for impaired fasting glucose: impact on disease prevalence and associated risk of diabetes and ischemic heart disease. Diabetes Care. 2004;27(7):1728–34.

PubMed  Article  PubMed Central  Google Scholar 

Nguyen BM, Lin KW, Mishori R. Public health implications of overscreening for carotid artery stenosis, prediabetes, and thyroid cancer. Public Health Rev. 2018;39:18.

PubMed  PubMed Central  Article  Google Scholar 

Piller C. Dubious diagnosis. Science. 2019;363(6431):1026–31.

CAS  PubMed  Article  PubMed Central  Google Scholar 

Kwong RY, Sattar H, Wu H, Vorobiof G, Gandla V, Steel K, et al. Incidence and prognostic implication of unrecognized myocardial scar characterized by cardiac magnetic resonance in diabetic patients without clinical evidence of myocardial infarction. Circulation. 2008;118(10):1011–20.

PubMed  PubMed Central  Article  Google Scholar 

Ohyama Y, Volpe GJ, Lima JAC. Subclinical myocardial disease in heart failure detected by CMR. Curr Cardiovasc Imaging Rep. 2014;7:9269.

PubMed  PubMed Central  Article  Google Scholar 

Sinnaeve PR, Steg PG, Fox KA, Van de Werf F, Montalescot G, Granger CB, et al. Association of elevated fasting glucose with increased short-term and 6-month mortality in ST-segment elevation and non-ST-segment elevation acute coronary syndromes: the Global Registry of Acute Coronary Events. Arch Intern Med. 2009;169(4):402–9.

CAS  PubMed  Article  PubMed Central  Google Scholar 

Giraldez RR, Clare RM, Lopes RD, Dalby AJ, Prabhakaran D, Brogan GX Jr, et al. Prevalence and clinical outcomes of undiagnosed diabetes mellitus and prediabetes among patients with high-risk non-ST-segment elevation acute coronary syndrome. Am Heart J. 2013;165(6):918-25.e2.

PubMed  Article  PubMed Central  Google Scholar 

Vistisen D, Witte DR, Brunner EJ, Kivimaki M, Tabak A, Jorgensen ME, et al. Risk of cardiovascular disease and death in individuals with prediabetes defined by different criteria: the Whitehall II study. Diabetes Care. 2018;41(4):899–906.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bartnik M, Malmberg K, Norhammar A, Tenerz A, Ohrvik J, Ryden L. Newly detected abnormal glucose tolerance: an important predictor of long-term outcome after myocardial infarction. Eur Heart J. 2004;25(22):1990–7.

CAS  PubMed  Article  PubMed Central  Google Scholar 

Neumann JT, Twerenbold R, Ojeda F, Sorensen NA, Chapman AR, Shah ASV, et al. Application of high-sensitivity troponin in suspected myocardial infarction. N Engl J Med. 2019;380(26):2529–40.

CAS