1. Donkor, ES . Stroke in the 21st century: a snapshot of the burden, epidemiology, and quality of life. Stroke Res Treat. 2018;2018:3238165.
Google Scholar | Crossref | Medline2. Virani, SS, Alonso, A, Benjamin, EJ, et al.; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee . Heart disease and stroke statistics—2020 update: a report from the American Heart Association. Circulation. 2020;141(9):e139–e596.
Google Scholar | Crossref | Medline3. Béjot, Y, Bailly, H, Durier, J, Giroud, M. Epidemiology of stroke in Europe and trends for the 21st century. Press Medicale. 2016;45(12):e391–e398. doi:10.1016/j.lpm.2016.10.003
Google Scholar | Crossref | Medline4. Kusuma, Y, Venketasubramanian, N, Kiemas, LS, Misbach, J. Burden of stroke in Indonesia. Int J Stroke. 2009;4(5):379–380.
Google Scholar | SAGE Journals5. Heurteaux, C, Gandin, C, Borsotto, M, et al. Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo. Neuropharmacology. 2010;58(7):987–1001.
Google Scholar | Crossref | Medline6. Young, SHY, Zhao, Y, Koh, A, et al.; CHIMES Investigators . Safety profile of MLC601 (Neuroaid®) in acute ischemic stroke patients: a Singaporean substudy of the Chinese medicine neuroaid efficacy on stroke recovery study. Cerebrovasc Dis. 2010;30(1):1–6.
Google Scholar | Crossref | Medline7. Chen, C, Venketasubramanian, N, Gan, RN, et al. Danqi Piantang Jiaonang (DJ), a traditional Chinese medicine, in poststroke recovery. Stroke. 2009;40(3):859–863.
Google Scholar | Crossref | Medline8. Zhang, C, Tao, W, Zhang, J, Liu, M, Li, J. Neuroaid for improving recovery after ischemic stroke. Cochrane Database Syst Rev. 2017;2017(8):1–8.
Google Scholar9. Quintard, H, Lorivel, T, Gandin, C, Lazdunski, M, Heurteaux, C. MLC901, a traditional Chinese medicine induces neuroprotective and neuroregenerative benefits after traumatic brain injury in rats. Neuroscience. 2014;277:72–86.
Google Scholar | Crossref | Medline10. Bavarsad Shahripour, R, Shamsaei, G, Pakdaman, H, et al. The effect of NeuroAiDTM (MLC601) on cerebral blood flow velocity in subjects’ post brain infarct in the middle cerebral artery territory. Eur J Intern Med. 2011;22(5):509–513.
Google Scholar | Crossref | Medline11. Heurteaux, C, Widmann, C, Moha Ou Maati, H, et al. NeuroAiD: properties for neuroprotection and neurorepair. Cerebrovasc Dis. 2013;35(suppl 1):1–7.
Google Scholar | Crossref | Medline12. Gandin, C, Widmann, C, Lazdunski, M, Heurteaux, C. MLC901 favors angiogenesis and associated recovery after ischemic stroke in mice. Cerebrovasc Dis. 2016;42(1-2):139–154.
Google Scholar | Crossref | Medline13. Widmann, C, Gandin, C, Petit-Paitel, A, Lazdunski, M, Heurteaux, C. The traditional Chinese medicine MLC901 inhibits inflammation processes after focal cerebral ischemia. Sci Rep. 2018;8(1):18062.
Google Scholar | Crossref | Medline14. Tagaya, M, Liu, KF, Copeland, B, et al. DNA scission after focal brain ischemia: temporal differences in two species. Stroke. 1997;28(6):1245–1254.
Google Scholar | Crossref | Medline15. Bederson, JB, Pitts, LH, Tsuji, M, Nishimura, MC, Davis, RL, Bartkowski, H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 1986;17(3):472–476.
Google Scholar | Crossref | Medline | ISI16. Zaidi, SF, Aghaebrahim, A, Urra, X, et al. Final infarct volume is a stronger predictor of outcome than recanalization in patients with proximal middle cerebral artery occlusion treated with endovascular therapy. Stroke. 2012;43(12):3238–3244.
Google Scholar | Crossref | Medline | ISI17. Thijs, VN, Lansberg, MG, Beaulieu, C, Marks, MP, Moseley, ME, Albers, GW. Is early ischemic lesion volume on diffusion-weighted imaging an independent predictor of stroke outcome? A multivariable analysis. Stroke. 2000;31(11):2597–2602.
Google Scholar | Crossref | Medline18. Kimura, K, Sakamoto, Y, Iguchi, Y, Shibazaki, K. Serial changes in ischemic lesion volume and neurological recovery after t-PA therapy. J Neurol Sci. 2011;304(1-2):35–39. doi:10.1016/j.jns.2011.02.024
Google Scholar | Crossref | Medline19. Lorivel, T, Gandin, C, Veyssière, J, Lazdunski, M, Heurteaux, C. Positive effects of the traditional Chinese medicine MLC901 in cognitive tasks. J Neurosci Res. 2015;93(11):1648–1663.
Google Scholar | Crossref | Medline20. Moher, D, Liberati, A, Tetzlaff, J, Altman, DG; PRISMA Group . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336–341.
Google Scholar | Crossref | Medline | ISI21. Hooijmans, CR, Rovers, MM, De Vries, RBM, Leenaars, M, Ritskes-Hoitinga, M, Langendam, MW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14(1):1–9.
Google Scholar | Crossref | Medline22. Gan, R, Lambert, C, Lianting, J, et al. Danqi Piantan Jiaonang does not modify hemostasis, hematology, and biochemistry in normal subjects and stroke patients. Cerebrovasc Dis. 2008;25(5):450–456.
Google Scholar | Crossref | Medline23. Schaar, KL, Brenneman, MM, Savitz, SI. Functional assessments in the rodent stroke model. Exp Transl Stroke Med. 2010;2(1):13.
Google Scholar | Crossref | Medline24. Schallert, T . Behavioral tests for preclinical intervention assessment. NeuroRx. 2006;3(4):497–504.
Google Scholar | Crossref | Medline25. Hua, Y, Schallert, T, Keep, RF, Wu, J, Hoff, JT, Xi, G. Behavioral tests after intracerebral hemorrhage in the rat. Stroke. 2002;33(10):2478–2484.
Google Scholar | Crossref | Medline