This study was supported by the Major Medical and Health Science and Technology Program of the National Health Commission (grant no: WKJ-ZJ-1912), the Natural Science Foundation of Zhejiang Province (grant no: Y20H180008). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.