Alzheimer’s and Consciousness: How Much Subjectivity Is Objective?

1. Moro, V. The interaction between implicit and explicit awareness in anosognosia: emergent awareness. Cogn Neurosci. 2013;4:199-200.
Google Scholar | Crossref | Medline2. Timmers, T, van Berckel, BNM, Lammertsma, AA, Ossenkoppele, R. Quantification of Tau load in Alzheimer’s disease clinical trials using positron emission tomography. Methods Mol Biol. 2018;1750:221-229.
Google Scholar | Crossref | Medline3. D’Iorio, A, Garramone, F, Piscopo, F, Baiano, C, Raimo, S, Santangelo, G. Meta-analysis of personality traits in Alzheimer’s disease: a comparison with healthy subjects. J Alzheimers Dis. 2018;62:773-787.
Google Scholar | Crossref | Medline4. Hameroff, S, Penrose, R. Consciousness in the universe: a review of the ‘Orch OR’ theory. Phys Life Rev. 2014;11:39-78.
Google Scholar | Crossref | Medline5. Hameroff, S. Quantum computation in brain microtubules? The Penrose–Hameroff “Orch OR” model of consciousness. Philos Trans A Math Phys Eng Sci. 1998;356:1869-1896.
Google Scholar | Crossref6. Burdick, RK, Villabona-Monsalve, JP, Mashour, GA, Goodson, T. Author Correction: Modern anesthetic ethers demonstrate quantum interactions with entangled photons. Sci Rep. 2021;11:8960.
Google Scholar | Crossref | Medline7. Li, N, Lu, D, Yang, L, et al. Nuclear spin attenuates the anesthetic potency of xenon isotopes in mice: implications for the mechanisms of anesthesia and consciousness. Anesthesiology. 2018;129:271-277.
Google Scholar | Crossref | Medline8. Li, T, Tang, H, Zhu, J, et al. The finer scale of consciousness: quantum theory. Ann Transl Med. 2019;7:585.
Google Scholar | Crossref | Medline9. McKemmish, LK, Reimers, JR, McKenzie, RH, Mark, AE, Hush, NS. Penrose-Hameroff orchestrated objective-reduction proposal for human consciousness is not biologically feasible. Phys Rev E Stat Nonlin Soft Matter Phys. 2009;80:021912.
Google Scholar | Crossref | Medline10. Penrose, R, Hameroff, SR. Consciousness in the universe an updated review of the “ORCH OR” theory. In: Poznanski, RR, Tuszynski, JA, Feinberg, TE, eds. Biophysics of Consciousness: A Foundational Approach. World Scientific; 2016.
Google Scholar11. Reimers, JR, McKemmish, LK, McKenzie, RH, Mark, AE, Hush, NS. The revised Penrose-Hameroff orchestrated objective-reduction proposal for human consciousness is not scientifically justified: comment on “consciousness in the universe: a review of the ‘Orch OR’ theory” by Hameroff and Penrose. Phys Life Rev. 2014;11:101-103; discussion 104-112.
Google Scholar | Crossref | Medline12. Smith, J, Zadeh Haghighi, H, Salahub, D, Simon, C. Radical pairs may play a role in xenon-induced general anesthesia. Sci Rep. 2021;11:6287.
Google Scholar | Crossref | Medline13. Bele, MS, Gajare, KA, Deshmukh, AA. Caloric restriction mimetic 2-deoxyglucose maintains cytoarchitecture and reduces tau phosphorylation in primary culture of mouse hippocampal pyramidal neurons. In Vitro Cell Dev Biol Anim. 2015;51:546-555.
Google Scholar | Crossref | Medline14. Richter-Landsberg, C. The cytoskeleton in oligodendrocytes. Microtubule dynamics in health and disease. J Mol Neurosci. 2008;35:55-63.
Google Scholar | Crossref | Medline15. Zhang, F, Su, B, Wang, C, et al. Posttranslational modifications of alpha-tubulin in alzheimer disease. Transl Neurodegener. 2015;4:015-0030.
Google Scholar | Crossref | Medline16. Cash, AD, Aliev, G, Siedlak, SL, et al. Microtubule reduction in Alzheimer’s disease and aging is independent of tau filament formation. Am J Pathol. 2003;162:1623-1627.
Google Scholar | Crossref | Medline17. Tang, R, Dai, J. Biophoton signal transmission and processing in the brain. J Photochem Photobiol B. 2014;139:71-75.
Google Scholar | Crossref | Medline18. Kattnig, DR, Solov’yov, IA, Hore, PJ. Electron spin relaxation in cryptochrome-based magnetoreception. Phys Chem Chem Phys. 2016;18:12443-12456.
Google Scholar | Crossref | Medline19. Brookes, JC. Quantum effects in biology: golden rule in enzymes, olfaction, photosynthesis and magnetodetection. Proc Math Phys Eng Sci. 2017;473:31.
Google Scholar20. Engel, GS, Calhoun, TR, Read, EL, et al. Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems. Nature. 2007;446:782-786.
Google Scholar | Crossref | Medline21. Panitchayangkoon, G, Hayes, D, Fransted, KA, et al. Long-lived quantum coherence in photosynthetic complexes at physiological temperature. Proc Natl Acad Sci U S A. 2010;107:12766-12770.
Google Scholar | Crossref | Medline22. Lee, H, Cheng, YC, Fleming, GR. Quantum coherence accelerating photosynthetic energy transfer. In: Corkum, P, Silvestri, S, Nelson, K, Riedle, E, Schoenlein, R, eds. Ultrafast Phenomena XVI. Springer Series in Chemical Physics, vol 92. Springer; 2009.
Google Scholar | Crossref23. Wiltschko, R, Ahmad, M, Niessner, C, Gehring, D, Wiltschko, W. Light-dependent magnetoreception in birds: the crucial step occurs in the dark. J R Soc Interface. 2016;13:20151010.
Google Scholar | Crossref | Medline24. Turin, L. A method for the calculation of odor character from molecular structure. J Theor Biol. 2002;216:367-385.
Google Scholar | Crossref | Medline25. Craddock, TJ, Priel, A, Tuszynski, JA. Keeping time: could quantum beating in microtubules be the basis for the neural synchrony related to consciousness? J Integr Neurosci. 2014;13:293-311.
Google Scholar | Crossref | Medline26. Craddock, TJ, Friesen, D, Mane, J, Hameroff, S, Tuszynski, JA. The feasibility of coherent energy transfer in microtubules. J R Soc Interface. 2014;11:20140677.
Google Scholar | Crossref | Medline27. Jibu, M, Hagan, S, Hameroff, SR, Pribram, KH, Yasue, K. Quantum optical coherence in cytoskeletal microtubules: implications for brain function. Biosystems. 1994;32:195-209.
Google Scholar | Crossref | Medline28. Adams, B, Petruccione, F. Quantum effects in the brain: a review. AVS Quantum Sci. 2020;2:022901.
Google Scholar | Crossref29. Hameroff, S, Penrose, R. Reply to criticism of the ‘Orch OR qubit’ – ‘orchestrated objective reduction’ is scientifically justified. Phys Life Rev. 2014;11:104-112.
Google Scholar | Crossref30. Craddock, TJA, Tuszynski, JA, Priel, A, Freedman, H. Microtubule ionic conduction and its implications for higher cognitive functions. J Integr Neurosci. 2010;9:103-122.
Google Scholar | Crossref | Medline31. Igamberdiev, AU, Shklovskiy-Kordi, NE. The quantum basis of spatiotemporality in perception and consciousness. Prog Biophys Mol Biol. 2017;130:15-25.
Google Scholar | Crossref | Medline32. Craddock, TJA, Kurian, P, Preto, J, et al. Anesthetic alterations of collective terahertz oscillations in tubulin correlate with clinical potency: implications for anesthetic action and post-operative cognitive dysfunction. Sci Rep. 2017;7:1-2.
Google Scholar | Crossref | Medline33. Sahu, S, Ghosh, S, Ghosh, B, et al. Atomic water channel controlling remarkable properties of a single brain microtubule: correlating single protein to its supramolecular assembly. Biosens Bioelectron. 2013;47:141-148.
Google Scholar | Crossref | Medline34. Bilotta, F, Qeva, E, Matot, I. Anesthesia and cognitive disorders: a systematic review of the clinical evidence. Expert Rev Neurother. 2016;16:1311-1320.
Google Scholar | Crossref | Medline35. Zhang, C, Zhang, Y, Shen, Y, Zhao, G, Xie, Z, Dong, Y. Anesthesia/surgery induces cognitive impairment in female Alzheimer’s disease transgenic mice. J Alzheimers Dis. 2017;57:505-518.
Google Scholar | Crossref | Medline36. Choi, GJ, Kang, H, Baek, CW, Jung, YH, Kim, JW, Woo, YC. Relationship between general anesthesia and Alzheimer disease: a protocol for a systematic review and meta-analysis. Medicine. 2017;96:e9314.
Google Scholar | Crossref | Medline37. Perry, G, Avila, J, Kinoshita, J, Smith, MA, eds. Alzheimer’s Disease: A Century of Scientific and Clinical Research. STM Publishing House, Impacting the World of Science Books & Journals, Online & Print; 2006.
Google Scholar38. Serino, S, Riva, G. The proactive self in space: how egocentric and allocentric spatial impairments contribute to anosognosia in Alzheimer’s disease. J Alzheimers Dis. 2017;55:881-892.
Google Scholar | Crossref | Medline39. Feher, EP, Mahurin, RK, Inbody, SB, Crook, TH, Pirozzolo, FJ. Anosognosia in Alzheimer’s disease. Neuropsychiatry Neuropsychol Behav Neurol. 1991;4:136-146.
Google Scholar40. Migliorelli, R, Teson, A, Sabe, L, et al. Anosognosia in Alzheimer’s disease: a study of associated factors. J Neuropsychiatry Clin Neurosci. 1995;7:338-344.
Google Scholar | Crossref | Medline41. Starkstein, SE. Anosognosia in Alzheimer’s disease: diagnosis, frequency, mechanism and clinical correlates. Cortex. 2014;61:64-73.
Google Scholar | Crossref | Medline42. Vasterling, JJ, Seltzer, B, Foss, JW, Vanderbrook, V. Unawareness of deficit in Alzheimer’s disease: domain-specific differences and disease correlates. Neuropsychiatry Neuropsychol Behav Neurol. 1995;8:26-32.
Google Scholar43. Avondino, E, Antoine, P. Heterogeneity of cognitive anosognosia and its variation with the severity of dementia in patients with Alzheimer’s disease. J Alzheimers Dis. 2016;50:89-99.
Google Scholar | Crossref | Medline44. Koltai, DC, Welsh-Bohmer, KA, Schmechel, DE. Influence of anosognosia on treatment outcome among dementia patients. Neuropsychol Rehabil. 2001;11:455-475.
Google Scholar | Crossref45. Mowrey, WB, Lipton, RB, Katz, MJ, et al. Memory binding test predicts incident dementia: results from the Einstein Aging Study. J Alzheimers Dis. 2018;62:293-304.
Google Scholar | Crossref | Medline46. Neuman, Y, Nave, O. Why the brain needs language in order to be self-conscious. New Ideas Psychol. 2010;28:37-48.
Google Scholar | Crossref47. Forsythe, A, Williams, T, Reilly, RG. What paint can tell us: a fractal analysis of neurological changes in seven artists. Neuropsychology. 2017;31:1-10.
Google Scholar | Crossref | Medline48. Forbes-McKay, KE, Venneri, A. Detecting subtle spontaneous language decline in early Alzheimer’s disease with a picture description task. Neurol Sci. 2005;26:243-254.
Google Scholar | Crossref | Medline49. Leslie, M. Telltale text. Novelist’s final work reveals early signs of Alzheimer’s disease. Sci Aging Knowledge Environ. 2004;2004:nf113.
Google Scholar50. Sahlas, DJ. Dementia with Lewy bodies and the neurobehavioral decline of Mervyn Peake. Arch Neurol. 2003;60:889-892.
Google Scholar | Crossref | Medline51. Snowdon, DA, Kemper, SJ, Mortimer, JA, Greiner, LH, Wekstein, DR, Markesbery, WR. Linguistic ability in early life and cognitive function and Alzheimer’s disease in late life. Findings from the Nun Study. JAMA. 1996;275:528-532.
Google Scholar | Crossref | Medline52. Fornazzari, LR. Preserved painting creativity in an artist with Alzheimer’s disease. Eur J Neurol. 2005;12:419-424.
Google Scholar | Crossref | Medline53. Forsythe, A, Nadal, M, Sheehy, N, Cela-Conde, CJ, Sawey, M. Predicting beauty: fractal dimension and visual complexity in art. Br J Psychol. 2011;102:49-70.
Google Scholar | Crossref | Medline54. Van Buren, B, Bromberger, B, Potts, D, Miller, B, Chatterjee, A. Changes in painting styles of two artists

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