Takeuchi T. Biomarkers as a treatment guide in rheumatoid arthritis. Clin Immunol. 2018;186:59–62. https://doi.org/10.1016/j.clim.2017.07.019.

CAS  Article  PubMed  Google Scholar 

Atkinson AJ, Colburn WA, DeGruttola VG, DeMets DL, Downing GJ, Hoth DF, et al. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69(3):89–95. https://doi.org/10.1067/mcp.2001.113989.

Article  Google Scholar 

Nakamura S, Suzuki K, Iijima H, Hata Y, Lim CR, Ishizawa Y, et al. Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study. Arthritis Res Ther. 2016;18(1):1–12. https://doi.org/10.1186/s13075-016-1052-8.

CAS  Article  Google Scholar 

Arora A, Mahajan A, Spurden D, Boyd H, Porter D. Long-term drug survival of TNF inhibitor therapy in RA patients: a systematic review of european national drug registers. Int J Rheumatol. 2013. https://doi.org/10.1155/2013/764518.

Article  PubMed  PubMed Central  Google Scholar 

Agarwal SK, Glass RJ, Shadick NA, Coblyn JS, Anderson RJ, Maher NE, et al. Predictors of discontinuation of tumor necrosis factor inhibitors in patients with rheumatoid arthritis. J Rheumatol. 2008;35(9):1737–44.

PubMed  PubMed Central  Google Scholar 

Hirata S, Dirven L, Shen Y, Centola M, Cavet G, Lems WF, et al. A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study. Rheumatology. 2013;52(7):1202–7. https://doi.org/10.1093/rheumatology/kes362.

CAS  Article  PubMed  Google Scholar 

Ortega, F. Estrategias analíticas en la investigación de nuevos biomarcadores. Monografía XXX: Biomarcadores: Analítica, Diagnóstico y Terapéutica. 2010:13–54.

Puentes Osorio Y, Amariles Muñoz P, Aristizábal Bernal BH, Pinto Peñaranda LF, Calleja Hernández MA. Pharmacogenomics of etanercept, infliximab, adalimumab and methotrexate in rheumatoid arthritis. A structured review. Rev colomb reumatol. 2018;25(1):22–37. https://doi.org/10.1016/j.rcreu.2017.08.004 (ISSN 0121–8123).

Article  Google Scholar 

Nuez F, Carrillo JM. Los marcadores genéticos en la mejora vegetal. Valencia: Universitat Politécnica de Valencia; 2000.

Google Scholar 

U.S. Food & Drug Administration. U.S. Food & Drug administration. Biomarker qualification-Collaborative effort to qualify a drug development tool. FDA Case Study. 2017. https://www.fda.gov/media/104459/download

Amur S, LaVange L, Zineh I, Buckman-Garner S, Woodcock J. Biomarker qualification: toward a multiple stakeholder framework for biomarker development, regulatory acceptance, and utilization. Clin Pharmacol Ther. 2015;98:34–46. https://doi.org/10.1002/cpt.136.

CAS  Article  PubMed  Google Scholar 

Dorcely B, Katz K, Jagannathan R, Chiang SS, Oluwadare B, Goldberg IJ, Bergman M. Novel biomarkers for prediabetes, diabetes, and associated complications. Diabetes Metab Syndr Obes Targets Ther. 2017;10:345–61. https://doi.org/10.2147/DMSO.S100074.

CAS  Article  Google Scholar 

Roberts SG, Blute ML, Bergstralh EJ, Slezak JM, Zincke H. PSA doubling time as a predictor of clinical progression after biochemical failure following radical prostatectomy for prostate cancer. Mayo Clin Proc. 2001;76(6):576–81. https://doi.org/10.4065/76.6.576.

CAS  Article  PubMed  Google Scholar 

Lee CM, Lee SS, Lee JM, Cho HC, Kim WS, Kim HJ, et al. Early monitoring for detection of antituberculous drug-induced hepatotoxicity. Korean J Intern Med. 2016;31(1):65–72. https://doi.org/10.3904/kjim.2016.31.1.65.

CAS  Article  PubMed  Google Scholar 

Kheyfets VO, Dunning J, Truong U, Ivy DD, Hunter KA, Shandas R. Assessment of N-terminal prohormone B-type natriuretic peptide as a measure of vascular and ventricular function in pediatric pulmonary arterial hypertension. Pulm Circ. 2015;5(4):658–66. https://doi.org/10.1086/683697.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Margolis AR, Porter AL, Staresinic CE, Ray CA. Impact of an extended International Normalized Ratio follow-up interval on Healthcare Use among veteran patients on stable warfarin doses. Am J Health Syst Pharm. 2019;76(22):1848–52. https://doi.org/10.1093/ajhp/zxz209.

Article  PubMed  PubMed Central  Google Scholar 

Lock EA, Bonventre JV. Biomarkers in translation; past, present and future. Toxicology. 2008;245(3):163–6. https://doi.org/10.1016/j.tox.2007.12.004.

CAS  Article  PubMed  Google Scholar 

Amariles P, Faus MJ, Sabater D, Machuca M, Martínez-Martínez F. Atención farmacéutica seguimiento farmacoterapéutico y parámetros de efectividad y seguridad de la farmacoterapia. El Farmacéutico. 2006;362:84–100.

Google Scholar 

Mun S, Lee J, Park A, Kim HJ, Lee YJ, Son H, et al. Proteomics approach for the discovery of rheumatoid arthritis biomarkers using mass spectrometry. Int J Mol Sci. 2019;20(18):4368. https://doi.org/10.3390/ijms20184368.

CAS  Article  PubMed Central  Google Scholar 

Romo-García MF, Bastian Y, Zapata-Zuñiga M, Macías-Segura N, Castillo-Ortiz JD, Lara-Ramírez EE, et al. Identification of putative miRNA biomarkers in early rheumatoid arthritis by genome-wide microarray profiling: a pilot study. Gene. 2019;720:144081. https://doi.org/10.1016/j.gene.2019.144081.

CAS  Article  PubMed  Google Scholar 

Bernardes M, Madureira A, Oliveira A, Martins MJ, Lucas R, Costa L, et al. Coronary artery calcium score in female rheumatoid arthritis patients: Associations with apolipoproteins and disease biomarkers. Int J Rheum Dis. 2019;22(10):1841–56. https://doi.org/10.1111/1756-185x.13685.

CAS  Article  PubMed  Google Scholar 

Chen Q, Chen D, Li D. Platelet/lymphocyte, lymphocyte/monocyte, and neutrophil/lymphocyte ratios as biomarkers in patients with rheumatoid arthritis and rheumatoid arthritis-associated interstitial lung disease. Med Sci Monit. 2019;25:6474–81. https://doi.org/10.12659/MSM.916583.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Klimenta B, Nefic H, Prodanovic N, Jadric R, Hukic F. Association of biomarkers of inflammation and HLA-DRB1 gene locus with risk of developing rheumatoid arthritis in females. Rheumatol Int. 2019;39(12):2147–57. https://doi.org/10.1007/s00296-019-04429-y.

CAS  Article  PubMed  Google Scholar 

Nys G, Cobraiville G, Servais AC, Malaise MG, De Seny D, Fillet M. Targeted proteomics reveals serum amyloid A variants and alarmins S100A8-S100A9 as key plasma biomarkers of rheumatoid arthritis. Talanta. 2019;2019(204):507–17. https://doi.org/10.1016/J.TALANTA.2019.06.044.

Article  Google Scholar 

Sasaki C, Hiraishi T, Oku T, Okuma K, Suzumura K, Hashimoto M, et al. Metabolomic approach to the exploration of biomarkers associated with disease activity in rheumatoid arthritis. PLoS ONE. 2019;14(7):e0219400. https://doi.org/10.1371/journal.pone.0219400.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Rinaudo-Gaujous M, Blasco-Baque V, Miossec P, Gaudin P, Farge P, Roblin X, et al. Infliximab induced a dissociated response of severe periodontal biomarkers in rheumatoid arthritis patients. J Clin Med. 2019;8(5):751. https://doi.org/10.3390/jcm8050751.

CAS  Article  PubMed Central  Google Scholar 

Alivernini S, Bruno D, Tolusso B, Bui L, Petricca L, Gigante MR, et al. Differential synovial tissue biomarkers among psoriatic arthritis and rheumatoid factor/anti-citrulline antibody-negative rheumatoid arthritis. Arthr Res Ther. 2019;21(1):116. https://doi.org/10.1186/s13075-019-1898-7.

Article  Google Scholar 

Huang Y, Zheng S, Wang R, Tang C, Zhu J, Li J. CCL5 and related genes might be the potential diagnostic biomarkers for the therapeutic strategies of rheumatoid arthritis. Clin Rheumatol. 2019;38(9):2629–35. https://doi.org/10.1007/s10067-019-04533-1.

Article  PubMed  Google Scholar 

Ferreiro-Iglesias A, Montes A, Perez-Pampin E, Cañete JD, Raya E, Magro-Checa C, et al. Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors A potential SNP association with response to etanercept. PLoS ONE. 2019;14(2):e0213073. https://doi.org/10.1371/journal.pone.0213073.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Hambardzumyan K, Bolce RJ, Wallman JK, Van Vollenhoven RF, Saevarsdottir S. Serum biomarkers for prediction of response to methotrexate monotherapy in early rheumatoid arthritis: results from the SWEFOT trial. J Rheumatol. 2019;46(6):555–63. https://doi.org/10.3899/jrheum.180537.

CAS  Article  PubMed  Google Scholar 

Carlson AK, Rawle RA, Wallace CW, Adams E, Greenwood MC, Bothner B, June RK. Global metabolomic profiling of human synovial fluid for rheumatoid arthritis biomarkers. Clin Exp Rheumatol. 2019;37(3):393–9.

PubMed  Google Scholar 

Plant D, Maciejewski M, Smith S, Nair N, Hyrich K, Ziemek D, Barton A, Verstappen S. Profiling of gene expression biomarkers as a classifier of methotrexate nonresponse in patients with rheumatoid arthritis. Artritis Rheumatol. 2019;71:678–84. https://doi.org/10.1002/art.40810.

CAS  Article  Google Scholar 

Singh A, Patro PS, Aggarwal A. MicroRNA-132, miR-146a, and miR-155 as potential biomarkers of methotrexate response in patients with rheumatoid arthritis. Clin Rheumatol. 2018;38(3):877–84. https://doi.org/10.1007/s10067-018-4380-z.

Article  PubMed  Google Scholar 

Zhang R, Yang X, Wang J, Han L, Yang A, Zhang J, et al. Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome-wide gene expression profiling analysis. Mol Med Rep. 2019;19(1):30–40. https://doi.org/10.3892/mmr.2018.9677.

CAS  Article  PubMed  Google Scholar 

Chen Q, Zhang X, Xiong Y, Chen C, Lv S. The CD25+/CD4+ T cell ratio and levels of CII, CIX and CXI antibodies in serum may serve as biomarkers of pristane-induced arthritis in rats and Rheumatoid Arthritis in humans. Comp Biochem Physiol C: Toxicol Pharmacol. 2018;2018(217):25–31. https://doi.org/10.1016/j.cbpc.2018.11.013.

CAS  Article  Google Scholar 

Guo X, Wang S, Godwood A, Close D, Ryan PC, Roskos LK, White WI. Pharmacodynamic biomarkers and differential effects of TNF- and GM-CSF-targeting biologics in rheumatoid arthritis. Int J Rheum Dis. 2019;22(4):646–53. https://doi.org/10.1111/1756-185X.13395.

CAS  Article  PubMed  Google Scholar 

Zhang C, Li L, Zhang G, Chen K, Lu A. Deciphering potential correlations between new biomarkers and pattern classification in Chinese medicine by bioinformatics: two examples of rheumatoid arthritis. Chin J Integr Med. 2018. https://doi.org/10.1007/s11655-018-2571-8.

Article  PubMed  PubMed Central  Google Scholar 

Shervington L, Darekar A, Shaikh M, Mathews R, Shervington A. Identifying reliable diagnostic/predictive biomarkers for rheumatoid arthritis. Biomarker insights. 2018;13:1177271918801005. https://doi.org/10.1177/1177271918801005.

Article  PubMed  PubMed Central  Google Scholar 

Luo Q, Zhang L, Li X, Fu B, Deng Z, Qing C, et al. Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for rheumatoid arthritis. Clin Exp Immunol. 2018;194(1):118–24. https://doi.org/10.1111/cei.13181.