National Nature Science Foundation of China (grant no. 81702884), China Postdoctoral Science Foundation (grant no. 2017M612290), Nature Science Foundation of Shandong Province (grant no. ZR2016HB17), Medicine and Health Science Technology Foundation of Shandong Province (grant no. 2016WS0216 and 2015WS0381) and Science Foundation of Liaocheng People’s Hospital (grant no. LYQN201901). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.