Macrophages Unmasked: Their Pivotal Role in Driving Atherosclerosis in Systemic Lupus Erythematosus

Mok CC, Tse SM, Chan KL, Ho LY (2018) Effect of the metabolic syndrome on organ damage and mortality in patients with systemic lupus erythematosus: a longitudinal analysis. Clin Exp Rheumatol 36:389–395

PubMed  Google Scholar 

Tselios K, Gladman DD, Su J, Ace O, Urowitz MB (2017) Evolution of risk factors for atherosclerotic cardiovascular events in systemic lupus erythematosus: a longterm prospective study. J Rheumatol 44:1841–1849. https://doi.org/10.3899/jrheum.161121

Article  CAS  PubMed  Google Scholar 

Magder LS, Petri M (2012) Incidence of and risk factors for adverse cardiovascular events among patients with systemic lupus erythematosus. Am J Epidemiol 176:708–719. https://doi.org/10.1093/aje/kws130

Article  PubMed  PubMed Central  Google Scholar 

Bartels CM, Buhr KA, Goldberg JW, Bell CL, Visekruna M, Nekkanti S, Greenlee RT (2014) Mortality and cardiovascular burden of systemic lupus erythematosus in a US population-based cohort. J Rheumatol 41:680–687. https://doi.org/10.3899/jrheum.130874

Article  PubMed  PubMed Central  Google Scholar 

Urowitz MB, Bookman AA, Koehler BE, Gordon DA, Smythe HA, Ogryzlo MA (1976) The bimodal mortality pattern of systemic lupus erythematosus. Am J Med 60:221–225. https://doi.org/10.1016/0002-9343(76)90431-9

Article  CAS  PubMed  Google Scholar 

Rubin LA, Urowitz MB, Gladman DD (1985) Mortality in systemic lupus erythematosus: the bimodal pattern revisited. Q J Med 55:87–98

CAS  PubMed  Google Scholar 

Nikpour M, Urowitz MB, Gladman DD (2009) Epidemiology of atherosclerosis in systemic lupus erythematosus. Curr Rheumatol Rep 11:248–254. https://doi.org/10.1007/s11926-009-0035-z

Article  PubMed  Google Scholar 

Maksimowicz-McKinnon K, Selzer F, Manzi S, Kip KE, Mulukutla SR, Marroquin OC, Smitherman TC, Kuller LH, Williams DO, Wasko MC (2008) Poor 1-year outcomes after percutaneous coronary interventions in systemic lupus erythematosus: report from the National Heart Lung, and Blood Institute Dynamic Registry. Circ Cardiovasc Interv 1:201–208. https://doi.org/10.1161/CIRCINTERVENTIONS.108.788745

Article  PubMed  PubMed Central  Google Scholar 

Abu-Shakra M, Urowitz MB, Gladman DD, Gough J (1995) Mortality studies in systemic lupus erythematosus. Results from a single center II Predictor variables for mortality. J Rheumatol 22:1265–70

CAS  PubMed  Google Scholar 

Yang S, Zhao M, Jia S (2023) Macrophage: key player in the pathogenesis of autoimmune diseases. Front Immunol 14:1080310. https://doi.org/10.3389/fimmu.2023.1080310

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jing C, Castro-Dopico T, Richoz N, Tuong ZK, Ferdinand JR, Lok L, Loudon KW, Banham GD, Mathews RJ, Cader Z, Fitzpatrick S, Bashant KR, Kaplan MJ, Kaser A, Johnson RS, Murphy MP, Siegel RM, Clatworthy MR (2020) Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis. Proc Natl Acad Sci U S A 117:15160–15171. https://doi.org/10.1073/pnas.2000943117

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen W, Schilperoort M, Cao Y, Shi J, Tabas I, Tao W (2022) Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis. Nat Rev Cardiol 19:228–249. https://doi.org/10.1038/s41569-021-00629-x

Article  PubMed  Google Scholar 

Chen R, Zhang H, Tang B, Luo Y, Yang Y, Zhong X, Chen S, Xu X, Huang S, Liu C (2024) Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets. Signal Transduct Target Ther 9:130. https://doi.org/10.1038/s41392-024-01840-1

Article  PubMed  PubMed Central  Google Scholar 

Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, Nochy D, Debre P, Piette JC, Gorochov G (2005) Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 175:8392–8400. https://doi.org/10.4049/jimmunol.175.12.8392

Article  CAS  PubMed  Google Scholar 

Caielli S, Wan Z, Pascual V (2023) Systemic lupus erythematosus pathogenesis: interferon and beyond. Annu Rev Immunol 41:533–560. https://doi.org/10.1146/annurev-immunol-101921-042422

Article  CAS  PubMed  Google Scholar 

Frostegard J (2023) Systemic lupus erythematosus and cardiovascular disease. J Intern Med 293:48–62. https://doi.org/10.1111/joim.13557

Article  CAS  PubMed  Google Scholar 

Santiago-Raber ML, Montecucco F, Vuilleumier N, Miteva K, Baptista D, Carbone F, Pagano S, Roth A, Burger F, Mach F, Brandt KJ (2020) Atherosclerotic plaque vulnerability is increased in mouse model of lupus. Sci Rep 10:18324. https://doi.org/10.1038/s41598-020-74579-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stanic AK, Stein CM, Morgan AC, Fazio S, Linton MF, Wakeland EK, Olsen NJ, Major AS (2006) Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc Natl Acad Sci U S A 103:7018–7023. https://doi.org/10.1073/pnas.0602311103

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fukumoto S, Tsumagari T, Kinjo M, Tanaka K (1987) Coronary atherosclerosis in patients with systemic lupus erythematosus at autopsy. Acta Pathol Jpn 37:1–9. https://doi.org/10.1111/j.1440-1827.1987.tb03129.x

Article  CAS  PubMed  Google Scholar 

Lewandowski LB, Kaplan MJ (2016) Update on cardiovascular disease in lupus. Curr Opin Rheumatol 28:468–476. https://doi.org/10.1097/BOR.0000000000000307

Article  PubMed  PubMed Central  Google Scholar 

Samuelsson I, Parodis I, Gunnarsson I, Zickert A, Hofman-Bang C, Wallen H, Svenungsson E (2021) Myocardial infarctions, subtypes and coronary atherosclerosis in SLE: a case-control study. Lupus Sci Med 8. https://doi.org/10.1136/lupus-2021-000515

Ambler WG, Kaplan MJ (2024) Vascular damage in systemic lupus erythematosus. Nat Rev Nephrol 20:251–265. https://doi.org/10.1038/s41581-023-00797-8

Article  CAS  PubMed  Google Scholar 

Morand EF, Fernandez-Ruiz R, Blazer A, Niewold TB (2023) Advances in the management of systemic lupus erythematosus. BMJ 383:e073980. https://doi.org/10.1136/bmj-2022-073980

Article  PubMed  Google Scholar 

Man JJ, Beckman JA, Jaffe IZ (2020) Sex as a biological variable in atherosclerosis. Circ Res 126:1297–1319. https://doi.org/10.1161/CIRCRESAHA.120.315930

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nielsen RV, Fuster V, Bundgaard H, Fuster JJ, Johri AM, Kofoed KF, Douglas PS, Diederichsen A, Shapiro MD, Nicholls SJ, Nordestgaard BG, Lindholt JS, MacRae C, Yuan C, Newby DE, Urbina EM, Bergstrom G, Ridderstrale M, Budoff MJ, Bottcher M, Raitakari OT, Hansen TH, Naslund U, Sillesen H, Eldrup N, Ibanez B (2024) Personalized intervention based on early detection of atherosclerosis: JACC state-of-the-art review. J Am Coll Cardiol 83:2112–2127. https://doi.org/10.1016/j.jacc.2024.02.053

Article  CAS  PubMed  Google Scholar 

Tselios K, Gladman DD, Sheane BJ, Su J, Urowitz M (2019) All-cause, cause-specific and age-specific standardised mortality ratios of patients with systemic lupus erythematosus in Ontario, Canada over 43 years (1971–2013). Ann Rheum Dis 78:802–806. https://doi.org/10.1136/annrheumdis-2018-214802

Article  PubMed  Google Scholar 

Stojan G, Li J, Budoff M, Arbab-Zadeh A, Petri MA (2020) High-risk coronary plaque in SLE: low-attenuation non-calcified coronary plaque and positive remodelling index. Lupus Sci Med 7. https://doi.org/10.1136/lupus-2020-000409

Papazoglou N, Kravvariti E, Konstantonis G, Sfikakis PP, Tektonidou MG (2024) The impact of traditional cardiovascular risk factor control on 7-year follow-up atherosclerosis progression in systemic lupus erythematosus. Rheumatology (Oxford) 63:50–57. https://doi.org/10.1093/rheumatology/kead184

Article  CAS  PubMed  Google Scholar 

Filia A, Mitroulis I, Loukogiannaki C, Grigoriou M, Banos A, Sentis G, Giannouli S, Karali V, Athanasiadis E, Kokkinopoulos I, Boumpas DT (2024) Single-cell transcriptomic analysis of hematopoietic progenitor cells from patients with systemic lupus erythematosus reveals interferon-inducible reprogramming in early progenitors. Front Immunol 15:1383358. https://doi.org/10.3389/fimmu.2024.1383358

Article  CAS  PubMed  PubMed Central 

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