McDonagh TA et al (2022) 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC. Rev Esp Cardiol 75(6):005

Google Scholar 

Savarese G et al (2023) Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res 118(17):3272–3287

Article  PubMed  Google Scholar 

Shah KS et al (2017) Heart failure with preserved, borderline, and reduced ejection fraction: 5-year outcomes. J Am Coll Cardiol 70(20):2476–2486

Article  PubMed  Google Scholar 

Kawaguchi M et al (2003) Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations. Circulation 107(5):714–720

Article  PubMed  Google Scholar 

Borlaug BA, Paulus WJ (2011) Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J 32(6):670–679

Article  PubMed  Google Scholar 

Levy D et al (1996) The progression from hypertension to congestive heart failure. JAMA 275(20):1557–1562

Article  CAS  PubMed  Google Scholar 

Petersson M et al (2005) Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure. Eur Heart J 26(9):906–913

Article  PubMed  Google Scholar 

Hasking GJ et al (1986) Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 73(4):615–621

Article  CAS  PubMed  Google Scholar 

Schultz HD, Li YL, Ding Y (2007) Arterial chemoreceptors and sympathetic nerve activity: implications for hypertension and heart failure. Hypertension 50(1):6–13

Article  CAS  PubMed  Google Scholar 

Böhm M et al (2020) Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet 395(10234):1444–1451

Article  PubMed  Google Scholar 

Azizi M et al (2018) Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial. Lancet 391(10137):2335–2345

Article  PubMed  Google Scholar 

Krum H et al (2009) Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373(9671):1275–1281

Article  PubMed  Google Scholar 

Esler MD et al (2010) Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376(9756):1903–1909

Article  PubMed  Google Scholar 

Bhatt DL et al (2014) A controlled trial of renal denervation for resistant hypertension. N Engl J Med 370(15):1393–1401

Article  CAS  PubMed  Google Scholar 

Rey-García J, Townsend RR (2022) Renal denervation: a review. Am J Kidney Dis 80(4):527–535

Article  PubMed  Google Scholar 

Fudim M et al (2021) Renal denervation for patients with heart failure: making a full circle. Circ Heart Fail 14(3):e008301. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008301. Epub 2021 Mar 12

Kiuchi MG et al (2023) Multi-organ denervation: a novel approach to combat cardiometabolic disease. Hypertens Res 46(7):1747–1758

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H et al (2022) Pulmonary artery denervation for pulmonary arterial hypertension: a sham-controlled randomized PADN-CFDA trial. JACC Cardiovasc Interv 15(23):2412–2423

Article  PubMed  Google Scholar 

Singh JP, Kandala J, Camm AJ (2014) Non-pharmacological modulation of the autonomic tone to treat heart failure. Eur Heart J 35(2):77–85

Article  PubMed  Google Scholar 

Greenberg B (2020) Angiotensin receptor-neprilysin inhibition (ARNI) in heart failure. Int J Heart Fail 2(2):73–90

Article  PubMed  PubMed Central  Google Scholar 

Sharp TE 3rd, Lefer DJ (2021) Renal denervation to treat heart failure. Annu Rev Physiol 83:39–58

Volpe M et al (1991) Failure of atrial natriuretic factor to increase with saline load in patients with dilated cardiomyopathy and mild heart failure. J Clin Invest 88(5):1481–1489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Volpe M et al (1993) Abnormalities of sodium handling and of cardiovascular adaptations during high salt diet in patients with mild heart failure. Circulation 88(4 Pt 1):1620–1627

Article  CAS  PubMed  Google Scholar 

Volpe M et al (1997) Intrarenal determinants of sodium retention in mild heart failure: effects of angiotensin-converting enzyme inhibition. Hypertension 30(2 Pt 1):168–176

Article  CAS  PubMed  Google Scholar 

De Nicola L, Blantz RC, Gabbai FB (1992) Nitric oxide and angiotensin II. Glomerular and tubular interaction in the rat. J Clin Invest 89(4):1248–56

Haywood GA et al (1996) Expression of inducible nitric oxide synthase in human heart failure. Circulation 93(6):1087–1094

Article  CAS  PubMed  Google Scholar 

De Nicola L et al (1993) Arginine feeding modifies cyclosporine nephrotoxicity in rats. J Clin Invest 92(4):1859–1865

Article  PubMed  PubMed Central  Google Scholar 

Magri P et al (1998) Early impairment of renal hemodynamic reserve in patients with asymptomatic heart failure is restored by angiotensin II antagonism. Circulation 98(25):2849–2854

Article  CAS  PubMed  Google Scholar 

Fengler K et al (2017) Blood pressure response to main renal artery and combined main renal artery plus branch renal denervation in patients with resistant hypertension. J Am Heart Assoc 6(8):006196

Article  Google Scholar 

Fengler K et al (2017) Ultrasound-based renal sympathetic denervation for the treatment of therapy-resistant hypertension: a single-center experience. J Hypertens 35(6):1310–1317

Article  CAS  PubMed  Google Scholar 

Fengler K et al (2019) A three-arm randomized trial of different renal denervation devices and techniques in patients with resistant hypertension (RADIOSOUND-HTN). Circulation 139(5):590–600

Article  PubMed  Google Scholar 

Schlaich MP et al (2013) Feasibility of catheter-based renal nerve ablation and effects on sympathetic nerve activity and blood pressure in patients with end-stage renal disease. Int J Cardiol 168(3):2214–2220

Article  PubMed  Google Scholar 

Polhemus DJ et al (2017) Renal sympathetic denervation protects the failing heart via inhibition of neprilysin activity in the kidney. J Am Coll Cardiol 70(17):2139–2153

Article  PubMed  Google Scholar 

Brandt MC et al (2012) Effects of renal sympathetic denervation on arterial stiffness and central hemodynamics in patients with resistant hypertension. J Am Coll Cardiol 60(19):1956–1965

Article  PubMed  Google Scholar 

Pokushalov E et al (2013) Ganglionated plexus ablation vs linear ablation in patients undergoing pulmonary vein isolation for persistent/long-standing persistent atrial fibrillation: a randomized comparison. Heart Rhythm 10(9):1280–1286

Article  PubMed  Google Scholar 

Ferguson DW, Berg WJ, Sanders JS (1990) Clinical and hemodynamic correlates of sympathetic nerve activity in normal humans and patients with heart failure: evidence from direct microneurographic recordings. J Am Coll Cardiol 16(5):1125–1134

Article  CAS  PubMed  Google Scholar 

Fitzgerald AA et al (2011) Impact of medication nonadherence on hospitalizations and mortality in heart failure. J Card Fail 17(8):664–669

Article