Allen HK, Donato J, Wang HH, Cloud-Hansen KA, Davies J, Handelsman J. Call of the wild: antibiotic resistance genes in natural environments. Nat Rev Microbiol. 2010;8:251–9.

Article  CAS  PubMed  Google Scholar 

Zheng D, Yin G, Liu M, Hou L, Yang Y, Van Boeckel TP, et al. Global biogeography and projection of soil antibiotic resistance genes. Sci Adv. 2022;8:eabq8015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delgado-Baquerizo M, Hu H-W, Maestre FT, Guerra CA, Eisenhauer N, Eldridge DJ, et al. The global distribution and environmental drivers of the soil antibiotic resistome. Microbiome. 2022;10:219.

Article  PubMed  PubMed Central  Google Scholar 

D’Costa VM, King CE, Kalan L, Morar M, Sung WWL, Schwarz C, et al. Antibiotic resistance is ancient. Nature. 2011;477:457–61.

Article  PubMed  Google Scholar 

Larsson DGJ, Flach C-F. Antibiotic resistance in the environment. Nat Rev Microbiol. 2022;20:257–69.

Article  CAS  PubMed  Google Scholar 

Nesme J, Simonet P. The soil resistome: a critical review on antibiotic resistance origins, ecology and dissemination potential in telluric bacteria. Environ Microbiol. 2015;17:913–30.

Article  PubMed  Google Scholar 

Jiang X, Ellabaan MMH, Charusanti P, Munck C, Blin K, Tong Y, et al. Dissemination of antibiotic resistance genes from antibiotic producers to pathogens. Nat Commun. 2017;8:15784.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McCann CM, Christgen B, Roberts JA, Su JQ, Arnold KE, Gray ND, et al. Understanding drivers of antibiotic resistance genes in high Arctic soil ecosystems. Environ Int. 2019;125:497–504.

Article  CAS  PubMed  Google Scholar 

Makowska-Zawierucha N, Trzebny A, Zawierucha K, Manthapuri V, Bradley JA, Pruden A. Arctic plasmidome analysis reveals distinct relationships among associated antimicrobial resistance genes and virulence genes along anthropogenic gradients. Glob Chang Biol. 2024;30.

Chen QL, Hu HW, Yan ZZ, Zhu YG, He JZ, Delgado-Baquerizo M. Cross-biome antibiotic resistance decays after millions of years of soil development. ISME J. 2022;16:1864–7.

Article  PubMed  PubMed Central  Google Scholar 

Blois JL, Williams JW, Fitzpatrick MC, Jackson ST, Ferrier S. Space can substitute for time in predicting climate-change effects on biodiversity. Proc Natl Acad Sci U S A. 2013;110:9374–9.

Fukami T, Wardle DA. Long-term ecological dynamics: reciprocal insights from natural and anthropogenic gradients. Proc Biol Sci. 2005;272:2105–15.

Walker LR, Wardle DA, Bardgett RD, Clarkson BD. The use of chronosequences in studies of ecological succession and soil development. J Ecol. 2010;98:725–36.

Article  Google Scholar 

Wojcik R, Eichel J, Bradley JA, Benning LG. How allogenic factors affect succession in glacier forefields. Earth Sci Rev. 2021;218:103642.

Article  Google Scholar 

Post E, Alley RB, Christensen TR, Macias-Fauria M, Forbes BC, Gooseff MN, et al. The polar regions in a 2°C warmer world. Sci Adv. 2019;5:eeaaw9883.

Article  Google Scholar 

Rantanen M, Karpechko AYu, Lipponen A, Nordling K, Hyvärinen O, Ruosteenoja K, et al. The Arctic has warmed nearly four times faster than the globe since 1979. Commun Earth Environ. 2022;3:168.

Article  Google Scholar 

Bradley JA, Singarayer JS, Anesio AM. Microbial community dynamics in the forefield of glaciers. Proceedings of the Royal Society B: Biological Sciences. 2014;281:20140882.

Qian X, Sun W, Gu J, Wang XJ, Sun JJ, Yin YN, et al. Variable effects of oxytetracycline on antibiotic resistance gene abundance and the bacterial community during aerobic composting of cow manure. J Hazard Mater. 2016;315:61–9.

Article  CAS  PubMed  Google Scholar 

Chen B, Liang X, Nie X, Huang X, Zou S, Li X. The role of class I integrons in the dissemination of sulfonamide resistance genes in the Pearl River and Pearl River Estuary, South China. J Hazard Mater. 2015;282:61–7.

Article  CAS  PubMed  Google Scholar 

Hwengwere K, Paramel Nair H, Hughes KA, Peck LS, Clark MS, Walker CA. Antimicrobial resistance in Antarctica: is it still a pristine environment? Microbiome. 2022;10:71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Monteux S, Keuper F, Fontaine S, Gavazov K, Hallin S, Juhanson J, et al. Carbon and nitrogen cycling in Yedoma permafrost controlled by microbial functional limitations. Nat Geosci. 2020;13:794–8.

Article  CAS  Google Scholar 

Bradley JA, Arndt S, Šabacká M, Benning LG, Barker GL, Blacker JJ, et al. Microbial dynamics in a high Arctic glacier forefield: a combined field, laboratory, and modelling approach. Biogeosciences. 2016;13:5677–96.

Article  Google Scholar 

Nemergut DR, Schmidt SK, Fukami T, O’Neill SP, Bilinski TM, Stanish LF, et al. Patterns and processes of microbial community assembly. Microbiol Mol Biol Rev. 2013;77:342–56.

Article  PubMed  PubMed Central  Google Scholar 

Jousset A, Schmid B, Scheu S, Eisenhauer N. Genotypic richness and dissimilarity opposingly affect ecosystem functioning. Ecol Lett. 2011;14:537–45.

Article  CAS  PubMed  Google Scholar 

Yu X, Polz MF, Alm EJ. Interactions in self-assembled microbial communities saturate with diversity. ISME J. 2019;13:1602–17.

Article  PubMed  PubMed Central  Google Scholar 

Morlon H. Microbial cooperative warfare. Sci (1979). 2012;337:1184–5.

CAS  Google Scholar 

Bourriquen M, Mercier D, Baltzer A, Fournier J, Costa S, Roussel E. Paraglacial coasts responses to glacier retreat and associated shifts in river floodplains over decadal timescales (1966–2016), Kongsfjorden, Svalbard. Land Degrad Dev. 2018;29:4173–85.

Article  Google Scholar 

Robertson GP, Coleman DC, Bledsoe CS, Sollins P. Standard soil methods for long-term ecological research. New York, NY: Oxford University Press; 1999.

Book  Google Scholar 

Marcoleta AE, Arros P, Varas MA, Costa J, Rojas-Salgado J, Berríos-Pastén C, et al. The highly diverse Antarctic Peninsula soil microbiota as a source of novel resistance genes. Sci Total Environ. 2022;810:152003.

Article  CAS  PubMed  Google Scholar 

Van Goethem MW, Pierneef R, Van De Bezuidt OKI, Cowan DA, Makhalanyane TP. A reservoir of historical antibiotic resistance genes in remote pristine Antarctic soils. Microbiome. 2018;6:1–12.

Google Scholar 

Jara D, Bello-Toledo H, Domínguez M, Cigarroa C, Fernández P, Vergara L, et al. Antibiotic resistance in bacterial isolates from freshwater samples in Fildes Peninsula, King George Island, Antarctica. Sci Rep. 2020;10:3145.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen JP, Li ZM, Hu HW, Zeng J, Zhang LM, Du S et al. Distribution and succession feature of antibiotic resistance genes along a soil development chronosequence in urumqi no.1 glacier of China. Front Microbiol. 2019;10 JULY:1569.

Shahsavari E, Aburto-Medina A, Taha M, Ball AS. A quantitative PCR approach for quantification of functional genes involved in the degradation of polycyclic aromatic hydrocarbons in contaminated soils. MethodsX. 2016;3:205–11.

Article  PubMed  PubMed Central  Google Scholar 

Looft T, Johnson TA, Allen HK, Bayles DO, Alt DP, Stedtfeld RD et al. In-feed antibiotic effects on the swine intestinal microbiome. Proc Natl Acad Sci U S A. 2012;109:1691–6.

R Development Core Team. R: A Language and Environment for Statistical Computing. 2020.

Alcock BP, Huynh W, Chalil R, Smith KW, Raphenya AR, Wlodarski MA, et al. CARD 2023: expanded curation, support for machine learning, and resistome prediction at the comprehensive antibiotic resistance database. Nucleic Acids Res. 2023;51:D690–9.

Article  CAS  PubMed  Google Scholar 

Hyatt D, Chen G-L, LoCascio PF, Land ML, Larimer FW, Hauser LJ. Prodigal: prokaryotic gene recognition and translation initiation site identification. BMC Bioinformatics. 2010;11:119.

Article  PubMed  PubMed Central  Google Scholar 

Buchfink B, Xie C, Huson DH. Fast and sensitive protein alignment using DIAMOND. Nat Methods. 2015;12:59–60.

Article  CAS  PubMed  Google Scholar 

Benjamin AM, Nichols M, Burke TW, Ginsburg GS, Lucas JE. Comparing reference-based RNA-Seq mapping methods for non-human primate data. BMC Genomics. 2014;15:1–14.

Article  CAS  Google Scholar 

Pinheiro J, Bates D, DebRoy S, Sarkar D, R Development Core Team R. nlme: Linear and Nonlinear Mixed Effects Models, R package version 3.1–148. 2020.

Sanchez G. PLS Path Modeling with R. Trowchez Editions. Berkeley; 2013.

Sanchez G, Trinchera L, Russolillo G. plspm: tools for partial least squares path modeling (PLS-PM). 2017.