Guo W, Li BL, Zhao JY, Li XM, Wang LF. Causal associations between modifiable risk factors and intervertebral disc degeneration. Spine J. 2024;24:195–209.

Article  PubMed  Google Scholar 

Yang L, Li W, Yang Y, Zhao H, Yu X. The correlation between the lumbar disc MRI high-intensity zone and discogenic low back pain: a systematic review and meta-analysis. J Orthop Surg Res. 2023;18:758.

Article  PubMed  PubMed Central  Google Scholar 

Taso M, Sommernes JH, Kolstad F, Sundseth J, Bjorland S, Pripp AH, et al. A randomised controlled trial comparing the effectiveness of surgical and nonsurgical treatment for cervical radiculopathy. BMC Musculoskelet Disord. 2020;21:171.

Article  PubMed  PubMed Central  Google Scholar 

Mirzaeipoueinak M, Mordechai HS, Bangar SS, Sharabi M, Tipper JL, Tavakoli J. Structure-function characterization of the transition zone in the intervertebral disc. Acta Biomater. 2023;160:164–75.

Article  PubMed  Google Scholar 

Urban JP. The role of the physicochemical environment in determining disc cell behaviour. Biochem Soc Trans. 2002;30:858–64.

Article  PubMed  Google Scholar 

Staszkiewicz R, Gładysz D, Gralewski M, Garczarek M, Gadzieliński M, Grabarek BO. Pathomechanism of the IVDs degeneration and the role of neurotrophic factors and concentration of selected elements in Genesis of Low Back Pain. Curr Pharm Biotechnol. 2023;24:1164–77.

Article  PubMed  Google Scholar 

Gansau J, Buckley CT. Priming as a strategy to overcome detrimental pH effects on cells for intervertebral disc regeneration. Eur Cell Mater. 2021;41:153–69.

Article  PubMed  Google Scholar 

Grunhagen T, Wilde G, Soukane DM, Shirazi-Adl SA, Urban JP. Nutrient supply and intervertebral disc metabolism. J Bone Joint Surg Am. 2006;88(Suppl 2):30–5.

PubMed  Google Scholar 

Razaq S, Urban JP, Wilkins RJ. Regulation of intracellular pH by bovine intervertebral disc cells. Cell Physiol Biochem. 2000;10:109–15.

Article  PubMed  Google Scholar 

Zhang Y, Liu L, Qi Y, Lou J, Chen Y, Liu C, et al. Lactic acid promotes nucleus pulposus cell senescence and corresponding intervertebral disc degeneration via interacting with Akt. Cell Mol Life Sci. 2024;81:24.

Article  PubMed  PubMed Central  Google Scholar 

Zhou RP, Wu XS, Wang ZS, Xie YY, Ge JF, Chen FH. Novel insights into acid-sensing Ion channels: implications for degenerative diseases. Aging Dis. 2016;7:491–501.

Article  PubMed  Google Scholar 

Omerbašić D, Schuhmacher LN, Bernal Sierra YA, Smith ES, Lewin GR. ASICs and mammalian mechanoreceptor function. Neuropharmacology. 2015;94:80–6.

Article  PubMed  Google Scholar 

Abdelhamid RE, Sluka KA. ASICs mediate Pain and inflammation in Musculoskeletal diseases. Physiol (Bethesda). 2015;30:449–59.

Google Scholar 

Gilbert HTJ, Hodson N, Baird P, Richardson SM, Hoyland JA. Acidic pH promotes intervertebral disc degeneration: acid-sensing ion channel– 3 as a potential therapeutic target. Sci Rep. 2016;6:37360.

Article  PubMed  PubMed Central  Google Scholar 

Ruan N, Tribble J, Peterson AM, Jiang Q, Wang JQ, Chu XP. Acid-sensing Ion channels and mechanosensation. Int J Mol Sci 2021; 22:4810.

Song C, Cai W, Liu F, Cheng K, Guo D, Liu Z. An in-depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration. JOR Spine. 2022;5:e1233.

Article  PubMed  PubMed Central  Google Scholar 

Li H, Wang X, Pan H, Xiao C, Wang C, Guo S, et al. The mechanisms and functions of IL-1β in intervertebral disc degeneration. Exp Gerontol. 2023;177:112181.

Article  PubMed  Google Scholar 

Yang W, Yu XH, Wang C, He WS, Zhang SJ, Yan YG, et al. Interleukin-1β in intervertebral disk degeneration. Clin Chim Acta. 2015;450:262–72.

Article  PubMed  Google Scholar 

Guo D, Cheng K, Song C, Liu F, Cai W, Chen J, et al. Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng Decoction. Int Immunopharmacol. 2023;124:110844.

Article  PubMed  Google Scholar 

Zhou D, Mei Y, Song C, Cheng K, Cai W, Guo D, et al. Exploration of the mode of death and potential death mechanisms of nucleus pulposus cells. Eur J Clin Invest. 2024;54:e14226.

Article  PubMed  Google Scholar 

Liu ZC, Wang ZL, Huang CY, Fu ZJ, Liu Y, Wei ZC, et al. Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway. Acta Pharmacol Sin. 2018;39:912–22.

Article  PubMed  PubMed Central  Google Scholar 

Wang N, Rong W, Xie Y, Chen S, Xi Z, Deng R. Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration. Exp Gerontol. 2024;188:112380.

Article  PubMed  Google Scholar 

Coll RC, Schroder K, Pelegrín P. NLRP3 and pyroptosis blockers for treating inflammatory diseases. Trends Pharmacol Sci. 2022;43:653–68.

Article  PubMed  Google Scholar 

Hsu SK, Li CY, Lin IL, Syue WJ, Chen YF, Cheng KC, et al. Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment. Theranostics. 2021;11:8813–35.

Article  PubMed  PubMed Central  Google Scholar 

Vasudevan SO, Behl B, Rathinam VA. Pyroptosis-induced inflammation and tissue damage. Semin Immunol. 2023;69:101781.

Article  PubMed  PubMed Central  Google Scholar 

Zhou J, Qiu J, Song Y, Liang T, Liu S, Ren C, et al. Pyroptosis and degenerative diseases of the elderly. Cell Death Dis. 2023;14:94.

Article  PubMed  PubMed Central  Google Scholar 

Wei Y, Yang L, Pandeya A, Cui J, Zhang Y, Li Z. Pyroptosis-Induced inflammation and tissue damage. J Mol Biol. 2022;434:167301.

Article  PubMed  Google Scholar 

Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, et al. Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis. Immunity. 2023;56:2523–e25418.

Article  PubMed  PubMed Central  Google Scholar 

Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42:245–54.

Article  PubMed  Google Scholar 

Yan H, Luo B, Wu X, Guan F, Yu X, Zhao L, et al. Cisplatin induces pyroptosis via activation of MEG3/NLRP3/caspase-1/GSDMD pathway in Triple-negative breast Cancer. Int J Biol Sci. 2021;17:2606–21.

Article  PubMed  PubMed Central  Google Scholar 

Okajima F. Regulation of inflammation by extracellular acidification and proton-sensing GPCRs. Cell Signal. 2013;25:2263–71.

Article  PubMed  Google Scholar 

Chen X, Jaiswal A, Costliow Z, Herbst P, Creasey EA, Oshiro-Rapley N, et al. pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells. Nat Immunol. 2022;23:1063–75.

Article  PubMed  PubMed Central  Google Scholar 

Dai WY, Luo ZP. Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats. Cell Signal. 2022;91:110243.

Article  PubMed  Google Scholar 

Stover JD, Lawrence B, Bowles RD. Degenerative IVD conditioned media and acidic pH sensitize sensory neurons to cyclic tensile strain. J Orthop Res. 2021;39:1192–203.

Article  PubMed  Google Scholar 

Gotschall T, Resource Review. EndNote 21 desktop version. J Med Libr Assoc. 2023;111:852–3.

Article  PubMed  PubMed Central  Google Scholar 

Vella D, Marini S, Vitali F, Di Silvestre D, Mauri G, Bellazzi R. MTGO: PPI Network Analysis Via Topological and Functional Module Identification. Sci Rep. 2018;8:5499.